@immunopasteur.bsky.social (December 3, 2025, 9:28 am)

Excited to share our new preprint: “Local B cell maturation and mast cell regulation of choroid plexus function in early life” www.biorxiv.org/content/10.1... , initiated in the lab by Laetitia Travier and led by the one and only @fakesamir.bsky.social

Actualités à venir

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29

janv. 2025

Actualités passées

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Chaires d’excellence 2024: congratulations to Yasmine Belkaid

22

avr. 2024

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New publication – Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to...

25

mars 2024

Actualités

New publication – Smoking changes adaptive immunity with persistent effects

14

févr. 2024

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ERC Proof of concept grant 2023: congratulations to Lucie Peduto

25

janv. 2024

Actualités

Easy Panel

01

déc. 2023

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New publication – Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells pro...

06

oct. 2023

Actualités

New publication – Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a po...

24

août 2023

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Ludovic Deriano laureate of the Pasteur Vallery-Radot prize 2023

30

juin 2023

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New publication – Tissue-resident memory T cells mediate mucosal immunity to recu...

06

juin 2023

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New publication – Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN...

05

juin 2023

Actualités

New publication – Stromal regulation of the intestinal barrier

30

janv. 2023

Actualités

ERC Synergy grant 2022: congratulations to Caroline Demangel

25

oct. 2022

Actualités

New publication – Inflammation triggers ILC3 patrolling of the intestinal barrier

29

août 2022

Actualités

New publication – The neuropeptide VIP potentiates intestinal innate type 2 and t...

04

juil. 2022

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New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibo...

17

juin 2022

Actualités

New publication – High resolution microfluidic assay and probabilistic modeling r...

03

juin 2022

Présentation

Les réponses immunitaires sont des événements dynamiques et coordonnés qui se développent au sein de microenvironnements tissulaires complexes. Les recherches menées dans le Département d’Immunologie visent à découvrir de nouveaux mécanismes impliqués dans le développement et le fonctionnement du système immunitaire dans le but d’identifier de nouvelles stratégies thérapeutiques pour combattre les infections, les cancers et les maladies inflammatoires chroniques.

Credits: Peduto lab, Bousso lab, Alcover lab

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Le Département d’Immunologie est dirigé par Philippe Bousso (directeur) et Ludovic Deriano (directeur adjoint).

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Équipes

Laboratory

Anticorps en Thérapie et Pathologie

Pierre Bruhns

Laboratory

Dynamiques des Réponses Immunes

Philippe Bousso

Laboratory

Immunologie Humorale

Hugo Mouquet

Laboratory

Immunobiologie et Thérapie

Caroline Demangel

Laboratory

Immunorégulation

Lars Rogge

Laboratory

Immunité innée

James Di Santo

Laboratory

Intégrité du Génome, Immunité et Cancer

Ludovic Deriano

Laboratory

Microenvironnement et immunité

Gérard Eberl

Laboratory

Stroma, inflammation et réparation tissulaire

Lucie Peduto

UTechS

Platform

UTechS Single Cell Biomarkers

Milena Hasan

Laboratory

Immunologie Translationnelle

Darragh Duffy

Group

Inflammation et immunité des muqueuses

Molly Ingersoll

Laboratory

G5

Interactions cerveau-immunité

Aleksandra Deczkowska

Laboratory

Cellules dendritiques et immunité adaptative

Pierre Guermonprez

Laboratory

Meta-organisme

Yasmine Belkaid

Équipes associées

Laboratory

G5

Interactions Microbiote-Hôte

Benoit Chassaing

Laboratory

Macrophages et Cellules Endothéliales

Elisa Gomez Perdiguero

Laboratory

Biologie et Génétique de la Paroi Bactérienne

Ivo Gomperts Boneca

Laboratory

Chromatine et Infection

Mélanie Hamon

Laboratory

UMR

Biologie des Infections

Marc Lecuit

Laboratory

Neurobiologie intégrative des systèmes cholinergiques

Uwe Maskos

Laboratory

HIV, Inflammation et Persistances virales

Michaela Muller-Trutwin

Laboratory

Immunologie des Infections Fongiques

Jessica Quintin

Laboratory

Réservoirs viraux et contrôle immunitaire

Asier Sáez-Cirión

Laboratory

Virus and Immunity

Olivier Schwartz

Gestion

Philippe Bousso

Responsable de Structure

Directeur

Ludovic Deriano

Responsable de Structure

Deputy

Marie-Laure Goupil

Personnel Administratif

Cécile Peltekian

Manager de département

Emplois

Post-doctorant(e)

Postdoc in Cancer Biology and Microenvironment

Our laboratory has one position available for postdoctoral fellow in the area of Cancer Biology and Microenvironment. We are interested in mechanisms of tumor initiation and resistance, with an emphasis on tissue long lived […]

Partenaires

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Sélection de Publications

Télécharger

• 2025
  Mesquita Peixoto M, Soares-da-Silva F, Bonnet V, Zhou Y, Ronteix G, Santos RF, Mailhe MP, Nogueira G, Feng X, Pereira JP, Azzoni E, Anselmi G, de Bruijn MFTR, Perkins A, Baroud CN, Pinto-do-Ó P, Cumano A, Spatiotemporal dynamics of fetal liver hematopoietic niches., J Exp Med 2025 Feb; 222(2): .
• 2025
  Robert M, Villain E, Yatim N, Mageau A, Charles N, Culina S, Peiffer-Smadja N, Borie R, Duffy D, Sacré K, Comment on: Inflammatory plasma protein levels are elevated years before sarcoidosis diagnosis: a nested case-control study in Sweden., Eur Respir J 2025 Jan; 65(1): .
• 2024
  Terroba-Navajas P, Spatola M, Chuquisana O, Joubert B, de Vries JM, Dik A, Marmolejo L, Jönsson F, Lauc G, Kovac S, Prüss H, Wiendl H, Titulaer MJ, Honnorat J, Lünemann JD, Humoral signatures of Caspr2-antibody spectrum disorder track with clinical phenotypes and outcomes., Med 2024 Oct; (): .
• 2024
  Dejoux A, Zhu Q, Ganneau C, Goff OR, Godon O, Lemaitre J, Relouzat F, Huetz F, Sokal A, Vandenberghe A, Pecalvel C, Hunault L, Derenne T, Gillis CM, Iannascoli B, Wang Y, Rose T, Mertens C, Nicaise-Roland P, , England P, Mahévas M, de Chaisemartin L, Le Grand R, Letscher H, Saul F, Pissis C, Haouz A, Reber LL, Chappert P, Jönsson F, Ebo DG, Millot GA, Bay S, Chollet-Martin S, Gouel-Chéron A, Bruhns P, Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models., Sci Transl Med 2024 Sep; 16(764): eado4463.
• 2024
  Ruggiu M, Guérin MV, Corre B, Bardou M, Alonso R, Russo E, Garcia Z, Feldmann L, Lemaître F, Dusseaux M, Grandjean CL, Bousso P, Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes., J Exp Med 2024 Apr; 221(4): .
• 2024
  Saint-André V, Charbit B, Biton A, Rouilly V, Possémé C, Bertrand A, Rotival M, Bergstedt J, Patin E, Albert ML, Quintana-Murci L, Duffy D, Smoking changes adaptive immunity with persistent effects., Nature 2024 Feb; 626(8000): 827-835.
• 2023
  Boulch M, Cazaux M, Cuffel A, Guerin MV, Garcia Z, Alonso R, Lemaître F, Beer A, Corre B, Menger L, Grandjean CL, Morin F, Thieblemont C, Caillat-Zucman S, Bousso P, Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity., Nat Cancer 2023 Jul; 4(7): 968-983.
• 2023
  Jagot F, Gaston-Breton R, Choi AJ, Pascal M, Bourhy L, Dorado-Doncel R, Conzelmann KK, Lledo PM, Lepousez G, Eberl G, The parabrachial nucleus elicits a vigorous corticosterone feedback response to the pro-inflammatory cytokine IL-1β., Neuron 2023 May; (): .
• 2023
  Rousseau M, Lacerda Mariano L, Canton T, Ingersoll MA, Tissue-resident memory T cells mediate mucosal immunity to recurrent urinary tract infection., Sci Immunol 2023 May; 8(83): eabn4332.
• 2023
  Lamanna E, Conde E, Mougel A, Bonnefoy J, Colaone F, Godon O, Hamdi S, Kamphuis JBJ, Drouet B, Serra V, Bruhns P, Reber LL, A vaccine targeting human IL-4 and IL-13 protects against asthma in humanized mice., Allergy 2023 Feb; (): .
• 2022
  Jarade A, Garcia Z, Marie S, Demera A, Prinz I, Bousso P, Di Santo JP, Serafini N, , Inflammation triggers ILC3 patrolling of the intestinal barrier., Nat Immunol 2022 Aug; (): .
• 2022
  Travier L, Singh R, Sáenz Fernández D, Deczkowska A, , Microbial and immune factors regulate brain maintenance and aging., Curr Opin Neurobiol 2022 Jul; 76(): 102607.
• 2022
  Goncalves P, Doisne JM, Eri T, Charbit B, Bondet V, Posseme C, Llibre A, Casrouge A, Lenoir C, Neven B, Duffy D, Fischer A, Di Santo JP, Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency., Blood 2022 Apr; 139(17): 2585-2600.
• 2022
  Domenger A, Choisy C, Baron L, Mayau V, Perthame E, Deriano L, Arnulf B, Bories JC, Dadaglio G, Demangel C, , The Sec61 translocon is a therapeutic vulnerability in multiple myeloma., EMBO Mol Med 2022 03; 14(3): e14740.
• 2021
  Luzuriaga MA, Herbert FC, Brohlin OR, Gadhvi J, Howlett T, Shahrivarkevishahi A, Wijesundara YH, Venkitapathi S, Veera K, Ehrman R, Benjamin CE, Popal S, Burton MD, Ingersoll MA, De Nisco NJ, Gassensmith JJ, , Metal-Organic Framework Encapsulated Whole-Cell Vaccines Enhance Humoral Immunity against Bacterial Infection., ACS Nano 2021 Sep; (): .
• 2021
  Smith N, Goncalves P, Charbit B, Grzelak L, Beretta M, Planchais C, Bruel T, Rouilly V, Bondet V, Hadjadj J, Yatim N, Pere H, Merkling SH, Ghozlane A, Kernéis S, Rieux-Laucat F, Terrier B, Schwartz O, Mouquet H, Duffy D, Di Santo JP, , Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection., Nat Immunol 2021 Sep; 22(11):1428-1439.
• 2021
  Yatim N, Boussier J, Tetu P, Smith N, Bruel T, Charbit B, Barnabei L, Corneau A, Da Meda L, Allayous C, Baroudjian B, Jebali M, Herms F, Grzelak L, Staropoli I, Calmettes V, Hadjadj J, Peyrony O, Cassius C, LeGoff J, Kramkimel N, Aractingi S, Fontes M, Blanc C, Rieux-Laucat F, Schwartz O, Terrier B, Duffy D, Lebbé C, , Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection., Sci Adv 2021 08; 7(34): .
• 2021
  Conde E, Bertrand R, Balbino B, Bonnefoy J, Stackowicz J, Caillot N, Colaone F, Hamdi S, Houmadi R, Loste A, Kamphuis JBJ, Huetz F, Guilleminault L, Gaudenzio N, Mougel A, Hardy D, Snouwaert JN, Koller BH, Serra V, Bruhns P, Grouard-Vogel G, Reber LL, , Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice., Nat Commun 2021 May; 12(1): 2574.
• 2020
  Chevalier G, Siopi E, Guenin-Macé L, Pascal M, Laval T, Rifflet A, Boneca IG, Demangel C, Colsch B, Pruvost A, Chu-Van E, Messager A, Leulier F, Lepousez G, Eberl G, Lledo PM, , Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system., Nat Commun 2020 12; 11(1): 6363.
• 2020
  Rousseau M, O'Brien CJO, Antequera E, Zdimerova H, Cansever D, Canton T, Zychlinsky Scharff A & Ingersoll MA, Identification of sex differences in tumor-specific T cell infiltration in bladder tumor-bearing mice treated with BCG immunotherapy, Bladder Cancer, 2020 Oct.
• 2020
  Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen JI, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J, , , , , , , , , , , Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC, Casanova JL, Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science 2020 Oct; 370(6515): .
• 2020
  Yu W, Lescale C, Babin L, Bedora-Faure M, Lenden-Hasse H, Baron L, Demangel C, Yelamos J, Brunet E, Deriano L, , Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ., Nat Commun 2020 Oct; 11(1): 5239.
• 2020
  Guenin-Macé L, Morel JD, Doisne JM, Schiavo A, Boulet L, Mayau V, Goncalves P, Duchatelet S, Hovnanian A, Bondet V, Duffy D, Ungeheuer MN, Delage M, Nassif A, Di Santo JP, Demangel C, , Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa., 2020 Sep 24;140598..
• 2020
  Elsaid R, Meunier S, Burlen-Defranoux O, Soares-da-Silva F, Perchet T, Iturri L, Freyer L, Vieira P, Pereira P, Golub R, Bandeira A, Gomez Perdiguero E, Cumano A, , A wave of bipotent T/ILC-restricted progenitors shapes the embryonic thymus microenvironment in a time-dependent manner., Blood 2021 Feb 25; 137(8): 1024-1036.
• 2020
  Bourdely P, Anselmi G, Vaivode K, Ramos RN, Missolo-Koussou Y, Hidalgo S, Tosselo J, Nuñez N, Richer W, Vincent-Salomon A, Saxena A, Wood K, Lladser A, Piaggio E, Helft J, Guermonprez P, Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells., Immunity 2020 Aug; 53(2): 335-352.e8.
• 2020
  Hadjadj J, Yatim N, Barnabei L, Corneau A, Boussier J, Smith N, Péré H, Charbit B, Bondet V, Chenevier-Gobeaux C, Breillat P, Carlier N, Gauzit R, Morbieu C, Pène F, Marin N, Roche N, Szwebel TA, Merkling SH, Treluyer JM, Veyer D, Mouthon L, Blanc C, Tharaux PL, Rozenberg F, Fischer A, Duffy D, Rieux-Laucat F, Kernéis S, Terrier B, , Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients., Science 2020 08; 369(6504): 718-724.
• 2020
  Juzans M, Cuche C, Rose T, Mastrogiovanni M, Bochet P, Di Bartolo V, Alcover A, , Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions., Immunohorizons 2020 06; 4(6): 363-381.
• 2020
  Hehle V, Beretta M, Bourgine M, Ait-Goughoulte M, Planchais C, Morisse S, Vesin B, Lorin V, Hieu T, Stauffer A, Fiquet O, Dimitrov JD, Michel ML, Ungeheuer MN, Sureau C, Pol S, Di Santo JP, Strick-Marchand H, Pelletier N, Mouquet H, , Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers., J. Exp. Med. 2020 ; 217(10): .
• 2020
  Goncalves P, Charbit B, Lenoir C, , Duffy D, Fischer A, Di Santo JP, , Antibody-coated microbiota in nasopharynx of healthy individuals and IVIg-treated patients with hypogammaglobulinemia., J Allergy Clin Immunol 2020 06; 145(6): 1686-1690.e4.
• 2020
  Benabid A, Peduto L, Mesenchymal perivascular cells in immunity and disease, Curr. Opin. Immunol. 2020 May;64:50-55.
• 2020
  Allweiss L, Strick-Marchand H, In-vitro and in-vivo models for hepatitis B cure research., Curr Opin HIV AIDS 2020 May; 15(3): 173-179.
• 2020
  Gérard A, Woolfe A, Mottet G, Reichen M, Castrillon C, Menrath V, Ellouze S, Poitou A, Doineau R, Briseno-Roa L, Canales-Herrerias P, Mary P, Rose G, Ortega C, Delincé M, Essono S, Jia B, Iannascoli B, Richard-Le Goff O, Kumar R, Stewart SN, Pousse Y, Shen B, Grosselin K, Saudemont B, Sautel-Caillé A, Godina A, McNamara S, Eyer K, Millot GA, Baudry J, England P, Nizak C, Jensen A, Griffiths AD, Bruhns P, Brenan C, High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics, Nat. Biotechnol. 2020 Mar;.
• 2020
  Ronan Thibaut, Pierre Bost, Idan Milo, Marine Cazaux, Fabrice Lemaître, Zacarias Garcia, Ido Amit, Béatrice Breart, Clémence Cournuot, Benno Schwikowski, Philippe Bousso, Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment, Nature Cancer 2020 Mar 1(3):302-314.
• 2020
  Li Z, Rotival M, Patin E, Michel F, Pellegrini S, , Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage., PLoS One 2020 ; 15(1): e0225289.
• 2018
  Milo I, Bedora-Faure M, Garcia Z, Thibaut R, Périé L, Shakhar G, Deriano L, Bousso P, The immune system profoundly restricts intratumor genetic heterogeneity, Sci Immunol 2018 Nov;3(29).
• 2018
  Dev H, Chiang TW#, Lescale C#, de Krijger I#, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wei W, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O'Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L*, Jacobs JJL*, Galanty Y*, Jackson SP.*, Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells., Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18..
• 2018
  Li Y, Masse-Ranson G, Garcia Z, Bruel T, Kök A, Strick-Marchand H, Jouvion G, Serafini N, Lim AI, Dusseaux M, Hieu T, Bourgade F, Toubert A, Finke D, Schwartz O, Bousso P, Mouquet H, Di Santo JP, , A human immune system mouse model with robust lymph node development., Nat Methods 2018 08; 15(8): 623-630.
• 2017
  Kremsdorf D, Strick-Marchand H, Modeling hepatitis virus infections and treatment strategies in humanized mice, Curr Opin Virol 2017 Aug;25:119-125.
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Contact

Marie-Laure Goupil – Department of Immunology / Email: marie-laure.goupil@pasteur.fr Institut Pasteur 28 rue du Dr Roux, 75015 Paris.

Cécile Peltekian – Department of Immunology / Email: cecile.peltekian@pasteur.fr Institut Pasteur 28 rue du Dr Roux, 75015 Paris.