Maladies Infectieuses Emergentes
Ces cinquante dernières années, nous avons pu constater une croissance alarmante de l’émergence de nouveaux agents infectieux au sein des populations humaines. La lutte contre ces infections émergentes constitue une mission historique de l’Institut […]
Host fatty acids and immunity to Mycobacterium tuberculosis
While the special relationship between Mycobacterium tuberculosis (Mtb) and host lipids has long been known, it remains a challenging enigma. It was clearly established that Mtb requires host fatty acids (FAs) and cholesterol to […]
Deciphering the causes of Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
Therapeutic potential of mycolactone and synthetic surrogates
Whether released by bacteria infecting the skin or injected via the subcutaneous route, mycolactone was found to diffuse into the leukocytes of peripheral blood and lymphoid organs. With this distribution profile, the unique effects […]
Immunity against Mycobacterium ulcerans : the subversive role of mycolactone
Mycobacterium ulcerans causes Buruli ulcer, a neglected tropical skin disease manifesting as chronic wounds that can leave victims with major, life-long deformity and disability. Differently from other mycobacteria, including the related M. tuberculosis and […]
Biomarkers of Buruli ulcer disease
Buruli ulcer is the third most common mycobacterial disease after Tuberculosis and Leprosy. It is a chronic, necrotizing disease of the skin and soft tissues that is reported in over thirty tropical and subtropical […]
Mycobacterial phenolic glycolipids and innate host defenses
Across different species of mycobacteria, phenolic glycolipids (PGL) share a common lipid core and phenol ring that are embedded in the cell envelope, and differ in the saccharidic portion that is exposed on the […]
Mycolactone of Mycobacterium ulcerans and the actin cytoskeleton
A distinctive feature of the human pathogen Mycobacterium ulcerans is the production of mycolactone. This original polyketide-derived macrolide is essential for bacterial virulence and sufficient to induce ulcerative lesions in the skin that are […]
2023Nutrient-dependent regulation of β-cell proinsulin content., J Biol Chem 2023 May; (): 104836.
2023Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity., Immunol Rev 2023 Mar; (): .
2023Click-chemistry-based protocol to quantitatively assess fatty acid uptake by Mycobacterium tuberculosis in axenic culture and inside mouse macrophages., STAR Protoc 2023 Jan; 4(1): 102062.
2023Sec61 blockade therapy overrides resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma., Front Oncol 2023 ; 13(): 1110916.
2022The Sec61 translocon is a therapeutic vulnerability in multiple myeloma., EMBO Mol Med 2022 03; 14(3): e14740.
2022Biochemical and Biological Assays of Mycolactone-Mediated Inhibition of Sec61., Methods Mol Biol 2022 ; 2387(): 163-181.
2022Mycolactone Purification from M. ulcerans Cultures and HPLC-Based Approaches for Mycolactone Quantification in Biological Samples., Methods Mol Biol 2022 ; 2387(): 117-130.
2021De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis., Elife 2021 Dec; 10(): .
2021Insights into the ancestry evolution of the Mycobacterium tuberculosis complex from analysis of Mycobacterium riyadhense., NAR Genom Bioinform 2021 Sep; 3(3): lqab070.
2021Immunity against Mycobacterium ulcerans: The subversive role of mycolactone., Immunol Rev 2021 Feb; (): .
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