Présentation

Le département Parasites et insectes vecteurs sonde le mode de vie des parasites et leurs vecteurs. Des recherches au cœur des enjeux mondiaux de santé publique, pour lesquels prévention, contrôle et traitement restent des préoccupations permanentes.

Le département étudie trois parasites eucaryotes majeurs responsables de maladies graves et aux répercussions sanitaires et économiques importantes, qui touchent la plus grande partie du monde : Plasmodium spp, agents du paludisme, Leishmania spp, agents de la leishmaniose, et Trypanosoma spp, responsable de la maladie du sommeil. Le moustique Anopheles, vecteur des Plasmodium et des virus, est étudié, ainsi que la mouche tsé-tsé, vecteur de la maladie du sommeil. Les travaux du département associent à la recherche fondamentale – sur des modèles in vitro et in vivo, avec une importante implication sur le terrain notamment en Afrique et Asie – une recherche appliquée, par exemple sur les bases de la résistance du parasite du paludisme aux antimalariques, ainsi que l’identification de nouveaux médicaments antiparasitaires. De nouveaux modèles et outils expérimentaux sont développés pour mieux comprendre les interactions dynamiques que ces micro-organismes établissent avec leur hôte, pour décoder les bases fondamentales du parasitisme et de la transmission par les vecteurs, pour élucider les mécanismes d’invasion de l’hôte, ainsi que pour déterminer les facteurs de virulence, la pathologie et les stratégies de survie de ces divers organismes.

Événements

“Trans-splicing and RNA modification regulate the life and death of Trypanosoma brucei”

Shulamit MICHAELI – Bar Ilan University (Ramat Gan – Israel) In the seminar I will report on the discovery and the mechanism of the spliced leader silencing (SLS) pathway which is induced under ER […]

2016-01-07 12:00:00 2016-01-07 13:00:00 Europe/London “Trans-splicing and RNA modification regulate the life and death of Trypanosoma brucei” Shulamit MICHAELI – Bar Ilan University (Ramat Gan – Israel) In the seminar I will report on the discovery and the mechanism of the spliced leader silencing (SLS) pathway which is induced under ER […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Protection against malaria is induced by blood stage-arresting Histamine Releasing Factor (HRF)-deficient Plasmodium parasites”

Claudia DEMARTA-GATSI – Unité de Biologie des interactions hôte-parasite (BIHP) Whole parasite vaccines such as genetically attenuated parasite (GAP) vaccines that induce cross-stage, long-lasting sterile protection have become the state-of-the-art to target malaria for […]

2016-01-28 12:00:00 2016-01-28 13:00:00 Europe/London “Protection against malaria is induced by blood stage-arresting Histamine Releasing Factor (HRF)-deficient Plasmodium parasites” Claudia DEMARTA-GATSI – Unité de Biologie des interactions hôte-parasite (BIHP) Whole parasite vaccines such as genetically attenuated parasite (GAP) vaccines that induce cross-stage, long-lasting sterile protection have become the state-of-the-art to target malaria for […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Avian malaria and the evolutionary ecology of host-parasite interactions”

Ana RIVERO  – Institut de Recherche pour le Développement (Montpellier – France) Avian malaria is the oldest experimental system for investigating the biology and transmission of Plasmodium parasites. It was the model used by […]

2016-02-04 12:00:00 2016-02-04 13:00:00 Europe/London “Avian malaria and the evolutionary ecology of host-parasite interactions” Ana RIVERO  – Institut de Recherche pour le Développement (Montpellier – France) Avian malaria is the oldest experimental system for investigating the biology and transmission of Plasmodium parasites. It was the model used by […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“The impact of hotspot targeted interventions on malaria transmission: an example of different scientific disciplines investigating public health solutions”

Amrish BAIDJOE – Institut Pasteur, Département de Virologie (Paris – France) Although malaria is a disease that till date still causes significant mortality and morbidity mostly among children, impressive reductions in prevalence have been […]

2016-02-18 12:00:00 2016-02-18 13:00:00 Europe/London “The impact of hotspot targeted interventions on malaria transmission: an example of different scientific disciplines investigating public health solutions” Amrish BAIDJOE – Institut Pasteur, Département de Virologie (Paris – France) Although malaria is a disease that till date still causes significant mortality and morbidity mostly among children, impressive reductions in prevalence have been […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Study of human hepatotropic pathogens in mice with humanized live”

Philip MEULEMAN – Gent university, Department of Clinical chemistry, microbiology and immunology (Gent – Belgique) Contact : Sylvie GARCIA (sylvie.garcia@pasteur.fr – 89.92)

2016-02-24 12:00:00 2016-02-24 13:00:00 Europe/London “Study of human hepatotropic pathogens in mice with humanized live” Philip MEULEMAN – Gent university, Department of Clinical chemistry, microbiology and immunology (Gent – Belgique) Contact : Sylvie GARCIA (sylvie.garcia@pasteur.fr – 89.92) Institut Pasteur, Rue du Docteur Roux, Paris, France

“Establishing a road map of the developmental program leading to infectivity in African trypanosomes”

Christian TSCHUDI – Yale University, School of Public Health (New Haven, USA) One of the fundamental steps in the life of a pathogen is the acquisition of infectivity. In the case of African trypanosomes, […]

2016-03-17 12:00:00 2016-03-17 13:00:00 Europe/London “Establishing a road map of the developmental program leading to infectivity in African trypanosomes” Christian TSCHUDI – Yale University, School of Public Health (New Haven, USA) One of the fundamental steps in the life of a pathogen is the acquisition of infectivity. In the case of African trypanosomes, […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Vivax sporozoite transcriptome: role of epigenetics in transcriptional regulation

Aaron JEX – Walter & Eliza Hall Institute, Faculty of Veterinary and Agricultural Sciences, Melbourne University (Parkville – Australie) Abstract: This seminar presents a transcriptomic, proteomic and histone epigenetic investigation of the sporozoite stage […]

2016-10-14 15:00:00 2016-10-14 15:45:00 Europe/London Vivax sporozoite transcriptome: role of epigenetics in transcriptional regulation Aaron JEX – Walter & Eliza Hall Institute, Faculty of Veterinary and Agricultural Sciences, Melbourne University (Parkville – Australie) Abstract: This seminar presents a transcriptomic, proteomic and histone epigenetic investigation of the sporozoite stage […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Intestinal epithelial cell-parasite cross-talk during giardiasis induces an anti-inflammatory state

Staffan SVÄRD – Department of Cell and Molecular Biology, Uppsala University (Uppsala – Suède) Abstract: Giardia intestinalis is a major cause of diarrhea but half of the infected remain asymptomatic. The mechanisms of disease […]

2016-10-14 15:45:00 2016-10-14 16:30:00 Europe/London Intestinal epithelial cell-parasite cross-talk during giardiasis induces an anti-inflammatory state Staffan SVÄRD – Department of Cell and Molecular Biology, Uppsala University (Uppsala – Suède) Abstract: Giardia intestinalis is a major cause of diarrhea but half of the infected remain asymptomatic. The mechanisms of disease […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Measuring malaria infections and infectiousness”

Bryan GREENHOUSE – University of California (San Francisco, USA) Biography: Dr. Bryan Greenhouse is an Associate Professor at the University of California, San Francisco in the Division of HIV, Infectious Diseases, and Global Health […]

2016-10-20 12:00:00 2016-10-20 13:00:00 Europe/London “Measuring malaria infections and infectiousness” Bryan GREENHOUSE – University of California (San Francisco, USA) Biography: Dr. Bryan Greenhouse is an Associate Professor at the University of California, San Francisco in the Division of HIV, Infectious Diseases, and Global Health […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Malaria transmission to the mosquito vector in Eastern Cambodia”

Amélie VANTAUX – Malaria Molecular Epidemiology Unit (Institut Pasteur du Cambodge) et Malaria Translational Research Unit (Institut Pasteur du Cambodge/Institut Pasteur Paris) Since 2008, Cambodia is again the center of new emerging resistances, this […]

2016-11-28 14:00:00 2016-11-28 15:00:00 Europe/London “Malaria transmission to the mosquito vector in Eastern Cambodia” Amélie VANTAUX – Malaria Molecular Epidemiology Unit (Institut Pasteur du Cambodge) et Malaria Translational Research Unit (Institut Pasteur du Cambodge/Institut Pasteur Paris) Since 2008, Cambodia is again the center of new emerging resistances, this […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Composition, function and dynamics of the trypanosome flagellum transition zone”

Samuel DEAN – University of Oxford (Oxford – Royaume uni) Cilia are highly conserved organelles present in most eukaryotic cell types. The transition zone (TZ) is a ciliary subdomain that acts as a “gate” […]

2017-01-05 10:00:00 2017-01-05 11:00:00 Europe/London “Composition, function and dynamics of the trypanosome flagellum transition zone” Samuel DEAN – University of Oxford (Oxford – Royaume uni) Cilia are highly conserved organelles present in most eukaryotic cell types. The transition zone (TZ) is a ciliary subdomain that acts as a “gate” […] Institut Pasteur, Paris, France

“Imaging host-pathogen interactions in the vascular compartment”

Christoph KONRADT – University of Pennsylvania (Philadelphia – USA) An important function of the blood-brain barrier is to exclude pathogens from the central nervous system, but some microorganisms benefit from the ability to enter […]

2017-01-09 10:00:00 2017-01-09 11:00:00 Europe/London “Imaging host-pathogen interactions in the vascular compartment” Christoph KONRADT – University of Pennsylvania (Philadelphia – USA) An important function of the blood-brain barrier is to exclude pathogens from the central nervous system, but some microorganisms benefit from the ability to enter […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Regulation of PfEMP1-VAR2CSA translation by a translation-enhancing factor (PTEF)” :

Mats WAHLGREN – Karolinska Institutet (Stockholm – Suède) Pregnancy-associated malaria commonly involves the binding of Plasmodium falciparum infected erythrocytes to placental chondroitin sulfate A through the PfEMP1-VAR2CSA protein. VAR2CSA is translationally repressed by an […]

2017-04-27 12:00:00 2017-04-27 14:00:00 Europe/London “Regulation of PfEMP1-VAR2CSA translation by a translation-enhancing factor (PTEF)” : Mats WAHLGREN – Karolinska Institutet (Stockholm – Suède) Pregnancy-associated malaria commonly involves the binding of Plasmodium falciparum infected erythrocytes to placental chondroitin sulfate A through the PfEMP1-VAR2CSA protein. VAR2CSA is translationally repressed by an […] 28 Rue du Docteur Roux, Paris, France

“Pre-mortem and post-mortem research on life-threatening paediatric infections”

Quique BASSAT – Barcelona Institute of Global health ISGlobal (Barcelone – Espagne) In spite of large efforts and generous investments, mortality statistics and cause of death (CoD) estimates from resource-constrained countries remain, as of […]

2017-05-11 00:00:00 2017-05-11 14:00:00 Europe/London “Pre-mortem and post-mortem research on life-threatening paediatric infections” Quique BASSAT – Barcelona Institute of Global health ISGlobal (Barcelone – Espagne) In spite of large efforts and generous investments, mortality statistics and cause of death (CoD) estimates from resource-constrained countries remain, as of […] 28 Rue du Docteur Roux, Paris, France

“New Malaria Vaccines”

Adrian V. S. Hill – Director, The Jenner Institute, University of Oxford, UK Preventing Malaria Mortality : a vaccine solution Malaria vaccine development has reached a remarkable turning point. One candidate vaccine has completed […]

2017-06-01 12:00:00 2017-06-01 13:00:00 Europe/London “New Malaria Vaccines” Adrian V. S. Hill – Director, The Jenner Institute, University of Oxford, UK Preventing Malaria Mortality : a vaccine solution Malaria vaccine development has reached a remarkable turning point. One candidate vaccine has completed […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Équipes