One of the main obstacles for studying the molecular and cellular mechanisms underlying human neurodevelopment in vivo is the scarcity of experimental models. The discovery that neurons can be generated from human induced pluripotent […]
Drug addiction is a complex psychiatric disorder. Several predisposing factors can contribute to the vulnerability to develop this pathology, including environmental and genetic ones. Although smoking prevalence has declined in recent years, certain subpopulations […]
Cocaine addiction (CocAdd) is a major public health issue affecting 3% of the worlwide population, without validated pharmacotherapy. Nicotinic acetylcholine receptors (nAChRs)have been repeatedly associated in Human and rodent response to cocaine. nAChRs alpha5 […]
Lung diseases are also a major public health problem. Chronic obstructive pulmonary disease (COPD) will be the third cause of mortality worldwide in 2020 and lung cancer is the leading cause of cancer-related mortality […]
There is experimental and biomedical evidence that the nicotinic acetylcholine receptor (nAChR) is implicated in Alzheimer’s Disease (AD) pathology. The only reasonably efficient FDA approved treatment for early stage AD, blockers of acetylcholine esterase […]
We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]
Understanding mechanisms underlying normal complex behaviours and the abnormalities that accompany most neuropathologies is a primary challenge in fundamental and biomedical research. However, optimal use of the large body of genetic, molecular, electrophysiological, behavioural […]
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Concept général du programme Le Grand Programme fédérateur Microbes & Brain (GPF M&B) réunit 17 équipes internationales de renom (Institut Pasteur Paris, Instituts Pasteur du réseau, Inserm, APHP) dans les domaines des Neurosciences, de […]
(EN) These videos show scans through transplants of human iPSC derived neurons.
They are from our recent paper in Developmental Biology:
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