Timeline
Mathieu Picardeau
Head of Structure
30 Sep 2024
publication
Leptospira interrogans biofilm transcriptome highlights adaption to starvation and general stress while maintaining virulence.
Read more01 Jul 2024
01 Apr 2024
publication
Inter-species Transcriptomic Analysis Reveals a Constitutive Adaptation Against Oxidative Stress for the Highly Virulent Leptospira Species.
Read more07 Feb 2024
publication
Diagnosis of human leptospirosis: systematic review and meta-analysis of the diagnostic accuracy of the Leptospira microscopic agglutination test, PCR targeting Lfb1, and IgM ELISA to Leptospira fainei serovar Hurstbridge.
Read more01 Feb 2024
01 Dec 2023
publication
Core genome sequencing and genotyping of Leptospira interrogans in clinical samples by target capture sequencing
Read more01 Nov 2023
publication
Histones with an unconventional DNA-binding mode in vitro are major chromatin constituents in the bacterium Bdellovibrio bacteriovorus.
Read more01 Nov 2023
publication
Phylogenomics of Leptospira santarosai, a prevalent pathogenic species in the Americas.
Read more12 Oct 2023
29 Aug 2023
event
Microbiology departement seminar : Brandon Jutras (Virginia Tech, Blacksburg, USA) ; Friday, September 15th @11.30am ; Auditorium F.Jacob
Read more14 Mar 2023
publication
Core genome sequencing and genotyping of Leptospira interrogans in clinical samples by target capture sequencing.
Read more01 Feb 2023
publication
Horizontal transfer of the rfb cluster in Leptospira is a genetic determinant of serovar identity.
Read more01 Jan 2023
01 Jan 2023
publication
Genetic diversity of Leptospira strains circulating in humans and dogs in France in 2019-2021.
Read more13 Oct 2022
01 Aug 2022
publication
Zoonoses and gold mining: A cross-sectional study to assess yellow fever immunization, Q fever, leptospirosis and leishmaniasis among the population working on illegal mining camps in French Guiana.
Read more11 Jul 2022
01 Jan 2022
publication
Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagella.
Read more13 Dec 2021
publication
Investigating the role of the carbon storage regulator A (CsrA) Leptospira spp.
Read more02 Dec 2021
publication
The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of Leptospira interrogans.
Read more02 Dec 2021
publication
The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence.
Read more01 Dec 2021
publication
Genetic diversity of Leptospira isolates in Lao PDR and genome analysis of an outbreak strain.
Read more01 Dec 2021
publication
Leptospira ainlahdjerensis sp. nov., Leptospira ainazelensis sp. nov., Leptospira abararensis sp. nov. and Leptospira chreensis sp. nov., four new species isolated from water sources in Algeria.
Read more17 Oct 2021
publication
Role of the major determinant of polar flagellation FlhG in the endoflagella-containing spirochete Leptospira.
Read more01 Oct 2021
01 Aug 2021
publication
International Committee on Systematics of Prokaryotes Subcommittee on the taxonomy of Leptospiraceae Minutes of the closed meeting, 10 July 2019, Vancouver, British Columbia, Canada.
Read more01 Jun 2021
publication
Ending the Neglect of Treatable Bacterial Zoonoses Responsible for Non-Malaria Fevers.
Read more01 May 2021
publication
Correction: 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka.
Read more23 Feb 2021
publication
Leptospira dzianensis and Leptospira putramalaysiae are later heterotypic synonyms of Leptospira yasudae and Leptospira stimsonii.
Read more03 Feb 2021
publication
Pathogenic Leptospira and water quality in African cities: A case study of Cotonou, Benin.
Read more01 Jan 2021
publication
Effect of disinfection agents and quantification of potentially viable Leptospira in fresh water samples using a highly sensitive integrity-qPCR assay.
Read more01 Jan 2021
publication
Investigating the role of the carbon storage regulator A (CsrA) in Leptospira spp.
Read more02 Dec 2020
publication
4-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen Leptospira interrogans.
Read more26 Nov 2020
06 Oct 2020
publication
The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress.
Read more01 Sep 2020
publication
Circulating genotypes of Leptospira in French Polynesia : An 9-year molecular epidemiology surveillance follow-up study.
Read more01 Aug 2020
publication
Correction: Genus-wide Leptospira core genome multilocus sequence typing for strain taxonomy and global surveillance.
Read more01 Aug 2020
01 Jul 2020
publication
Isolation of Leptospira interrogans from a Bottlenose Dolphin (Tursiops truncatus) in the Mediterranean Sea.
Read more12 Jun 2020
publication
The zoonotic pathogen Leptospira interrogans mitigates environmental stress through cyclic-di-GMP-controlled biofilm production.
Read more11 Mar 2020
publication
An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete.
Read more01 Jan 2020
publication
Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.
Read more01 Jan 2020
01 Jan 2020
publication
Core Genome Multi-locus Sequence Typing Analyses of Leptospira spp. Using the Bacterial Isolate Genome Sequence Database.
Read more01 Jan 2020
01 Jan 2020
publication
A first insight into the genomic diversity of Leptospira strains isolated from patients in Cuba.
Read more01 Jan 2020
01 Dec 2019
publication
Severe leptospirosis in non-tropical areas: a nationwide, multicentre, retrospective study in French ICUs.
Read more01 Sep 2019
publication
Usefulness of C-Reactive Protein in Differentiating Acute Leptospirosis and Dengue Fever in French Guiana.
Read more31 Jul 2019
publication
Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens
Read more01 Jun 2019
publication
Leptospirosis under the bibliometrics radar: evidence for a vicious circle of neglect
Read more01 May 2019
publication
Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics.
Read more01 May 2019
publication
High Prevalence of Leptospira spp. in Rodents in an Urban Setting in Madagascar.
Read more01 Apr 2019
publication
Genus-wide Leptospira core genome multilocus sequence typing for strain taxonomy and global surveillance.
Read more12 Feb 2019
publication
Gene silencing based on RNA-guided catalytically inactive Cas9 (dCas9): a new tool for genetic engineering in Leptospira
Read more09 Jan 2019
publication
A public database for the new MLST scheme for subsp. : surveillance and epidemiology of the causative agent of syphilis
Read more01 Nov 2018
publication
An outbreak of leptospirosis among kayakers in Brittany, North-West France, 2016.
Read more26 Sep 2018
publication
An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins
Read more13 Sep 2018
publication
Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis
Read more01 Sep 2018
publication
An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins
Read more10 Aug 2018
publication
International Committee on Systematics of Prokaryotes Subcommittee on the Taxonomy of Leptospiraceae. Minutes of the closed meeting, 28 November 2017, Palmerston North, New Zealand
Read more06 Aug 2018
publication
Characterization of LE3 and LE4, the only lytic phages known to infect the spirochete Leptospira.
Read more01 Aug 2018
19 Jul 2018
publication
Epidemiology of Human Leptospirosis in French Guiana (2007-2014): A Retrospective Study
Read more19 Jun 2018
publication
Genomic Comparison Among Global Isolates of Serovars Copenhageni and Icterohaemorrhagiae Identified Natural Genetic Variation Caused by an Indel
Read more08 May 2018
publication
FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete
Read more01 May 2018
publication
Biodiversity of Environmental : Improving Identification and Revisiting the Diagnosis
Read more06 Apr 2018
publication
The sigma factor σ is required for the long-term survival of Leptospira biflexa in water
Read more23 Feb 2018
publication
Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic
Read more14 Feb 2018
event
“Regulatory networks that control the Lyme Borreliosis spirochete’s infectious cycle”
Read more01 Feb 2018
publication
Leptospira venezuelensis sp. nov., a new member of the intermediate group isolated from rodents, cattle and humans.
Read more12 Jan 2018
publication
Structure and function of the Leptospira interrogans peroxide stress regulator (PerR), an atypical PerR devoid of a structural metal-binding site.
Read more03 Jan 2018
publication
Deciphering the unexplored Leptospira diversity from soils uncovers genomic evolution to virulence
Read more03 Jan 2018
01 Dec 2017
publication
LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition.
Read more01 Dec 2017
publication
Correction: Underestimation of Leptospirosis Incidence in the French West Indies.
Read more01 Oct 2017
publication
Pet rodents as possible risk for leptospirosis, Belgium and France, 2009 to 2016
Read more01 Aug 2017
publication
Isolation by culture and PCR identification of LipL32 gene of pathogenic Leptospira spp. in wild rats of Kuala Lumpur.
Read more01 Aug 2017
publication
[Leptospirosis in French Guiana and the Guiana shield: Current knowledge in 2016].
Read more01 Jun 2017
publication
Evaluation of different serological assays for early diagnosis of leptospirosis in Martinique (French West Indies).
Read more06 Mar 2017
21 Feb 2017
publication
Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis
Read more01 Feb 2017
publication
Diagnostic accuracy of an in-house ELISA using the intermediate species Leptospira fainei as antigen for diagnosis of acute leptospirosis in dogs.
Read more19 Jan 2017
publication
Genome-Wide Transcriptional Start Site Mapping and sRNA Identification in the Pathogen Leptospira interrogans
Read more17 Jan 2017
publication
The EbpA-RpoN Regulatory Pathway of the Pathogen Leptospira interrogans Is Essential for Survival in the Environment
Read more01 Jan 2017
publication
Population genetics, community of parasites, and resistance to rodenticides in an urban brown rat (Rattus norvegicus) population
Read more01 Aug 2016
publication
A novel flagellar sheath protein, FcpA, determines filament coiling, translational motility and virulence for the Leptospira spirochete.
Read more02 May 2016
publication
Real-time PCR reveals rapid dissemination of Leptospira interrogans after intraperitoneal and conjunctival inoculation of hamsters
Read more29 Apr 2016
04 Apr 2016
publication
Analysis of a Spontaneous Non-Motile and Avirulent Mutant Shows That FliM Is Required for Full Endoflagella Assembly in Leptospira interrogans.
Read more04 Apr 2016
publication
Estimating the Burden of Leptospirosis among Febrile Subjects Aged below 20 Years in Kampong Cham Communities, Cambodia, 2007-2009
Read more01 Apr 2016
publication
Molecular analysis of leptospires from serogroup Sejroe obtained from asymptomatic cattle in Rio de Janeiro – Brazil reveals genetic proximity to serovar Guaricura.
Read more11 Mar 2016
publication
Acquisition of negative complement regulators by the saprophyte Leptospira biflexa expressing LigA or LigB confers enhanced survival in human serum
Read more18 Feb 2016
publication
What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
Read more25 Jan 2016
publication
Erratum for Eshghi et al., Leptospira interrogans lpxD Homologue Is Required for Thermal Acclimatization and Virulence
Read more04 Dec 2015
publication
International Committee on Systematics of ProkaryotesSubcommittee on the taxonomy of LeptospiraceaeMinutes of the closed meeting, 8 October 2015, Semarang, Indonesia
Read more01 Dec 2015
05 Oct 2015
publication
Urban Market Gardening and Rodent-Borne Pathogenic Leptospira in Arid Zones: A Case Study in Niamey, Niger
Read more24 Sep 2015
10 Sep 2015
publication
Molecular Characterization and Serology of Leptospira kirschneri (Serogroup Grippotyphosa) Isolated from Urine of a Mare Post-Abortion in Brazil.
Read more01 Sep 2015
publication
Control of gene expression in Leptospira spp. by Transcription Activator-Like Effectors (TALEs) demonstrates a potential role for LigA and LigB in virulence in L. interrogans.
Read more31 Aug 2015
project
Genomic taxonomy of bacterial strains: universal nomenclatures for epidemiology and population biology
Read more25 Aug 2015
15 Aug 2015
01 Aug 2015
publication
Leptospira interrogans lpxD Homologue is Required for Thermal Acclimatization and Virulence.
Read more27 Jul 2015
27 Jul 2015
publication
Investigation of a leptospirosis outbreak in triathlon participants, Réunion Island, 2013
Read more08 Jul 2015
publication
Use of a New High Resolution Melting Method for Genotyping Pathogenic Leptospira spp
Read more06 Jul 2015
publication
Molecular characterization of Leptospira sp by multilocus variable number tandem repeat analysis (MLVA) from clinical samples: a case report
Read more04 Jul 2015
01 Jul 2015
publication
Neutrophil Extracellular Traps are Involved in the Innate Immune Response to Infection with Leptospira.
Read more23 May 2015
publication
Structural characterization of a novel subfamily of leucine-rich repeat proteins from the human pathogen Leptospira interrogans
Read more18 May 2015
publication
Pathogenic Leptospira interrogans Exoproteins Are Primarily Involved in Heterotrophic Processes
Read more11 May 2015
10 Apr 2015
publication
A replicative plasmid vector allows efficient complementation of pathogenic Leptospira strains.
Read more26 Feb 2015
publication
A multilocus variable number tandem repeat analysis assay provides high discrimination for genotyping Leptospira santarosai strains
Read more01 Jan 2015
11 Dec 2014
publication
Gene inactivation of a chemotaxis operon in the pathogen Leptospira interrogans
Read more01 Dec 2014
publication
Leptospira mayottensis sp. nov., a pathogenic species of the genus Leptospira isolated from humans.
Read more23 Sep 2014
publication
Leptospira mayottensis sp. nov., a pathogenic species of the genus Leptospira isolated from humans
Read more15 Sep 2014
publication
HemR is an OmpR/PhoB-like response regulator from Leptospira, which simultaneously effects transcriptional activation and repression of key haem metabolism genes
Read more04 Sep 2014
publication
First isolation of Leptospira noguchii serogroups Panama and Autumnalis from cattle
Read more25 Jul 2014
publication
Screening of a Leptospira biflexa mutant library to identify genes involved in ethidium bromide tolerance
Read more05 Jun 2014
31 Mar 2014
publication
A putative regulatory genetic locus modulates virulence in the pathogen Leptospira interrogans
Read more01 Jan 2014
publication
Molecular characterization of the first leptospires isolated from goats in Brazil.
Read more01 Dec 2013
publication
Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp.
Read more01 Oct 2013
publication
Rapid tests for diagnosis of leptospirosis: current tools and emerging technologies
Read more14 Mar 2013
publication
Serovar diversity of pathogenic Leptospira circulating in the French West Indies
Read more14 Mar 2013
publication
Evaluation of an in-house ELISA using the intermediate species Leptospira fainei for diagnosis of leptospirosis
Read more21 Sep 2012
26 Mar 2012
publication
FlaA proteins in Leptospira interrogans are essential for motility and virulence but are not required for formation of the flagellum sheath
Read more01 Jan 2012
publication
Construction of a library of random mutants in the spirochete Leptospira biflexa using a mariner transposon
Read more16 Sep 2011
05 Jul 2011
publication
Inactivation of clpB in the pathogen Leptospira interrogans reduces virulence and resistance to stress conditions
Read more09 Jun 2011
publication
Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin
Read more06 Apr 2011
publication
Comparison of real-time PCR assays for detection of pathogenic Leptospira spp. in blood and identification of variations in target sequences
Read more29 Oct 2010
publication
Expanding the genetic toolbox for Leptospira species by generation of fluorescent bacteria
Read more22 Jun 2010
publication
Isolation and characterization of new Leptospira genotypes from patients in Mayotte (Indian Ocean)
Read more28 May 2010
13 Sep 2009
publication
Transposition of fly mariner elements into bacteria as a genetic tool for mutagenesis
Read more01 May 2009
publication
Use of quantitative real-time PCR for studying the dissemination of Leptospira interrogans in the guinea pig infection model of leptospirosis
Read more01 May 2008
13 Feb 2008
publication
Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis
Read more30 Jan 2008
09 Nov 2007
publication
Conjugative transfer between Escherichia coli and Leptospira spp. as a new genetic tool
Read more01 Jul 2007
01 Jun 2007
21 Nov 2006
publication
A genomic island of the pathogen Leptospira interrogans serovar Lai can excise from its chromosome
Read more01 Nov 2006
publication
Application of multilocus variable-number tandem-repeat analysis for molecular typing of the agent of leptospirosis
Read more01 Jan 2006
publication
The scc spirochetal coiled-coil protein forms helix-like filaments and binds to nucleic acids generating nucleoprotein structures
Read more01 Jun 2005
publication
Complete nucleotide sequence of the LE1 prophage from the spirochete Leptospira biflexa and characterization of its replication and partition functions
Read more01 May 2005
publication
Random insertional mutagenesis of Leptospira interrogans, the agent of leptospirosis, using a mariner transposon
Read more01 May 2005
publication
Isolation and characterization of FecA- and FeoB-mediated iron acquisition systems of the spirochete Leptospira biflexa by random insertional mutagenesis
Read more12 Dec 2003
publication
The spirochetal chpK-chromosomal toxin-antitoxin locus induces growth inhibition of yeast and mycobacteria
Read more29 Aug 2003
publication
Genetic evidence for the existence of two pathways for the biosynthesis of methionine in the Leptospira spp
Read more01 Aug 2003
publication
Leptospira spp. possess a complete haem biosynthetic pathway and are able to use exogenous haem sources
Read more01 Mar 2003
publication
Construction and complementation of the first auxotrophic mutant in the spirochaete Leptospira meyeri
Read more01 Jan 2002
publication