Timeline

Mathieu Picardeau
Head of Structure
31 Jul 2019
publication

Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens

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01 Jun 2019
publication

Leptospirosis under the bibliometrics radar: evidence for a vicious circle of neglect

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23 May 2019
publication

Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics

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26 Apr 2019
publication

Genus-wide Leptospira core genome multilocus sequence typing for strain taxonomy and global surveillance

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12 Feb 2019
publication

Gene silencing based on RNA-guided catalytically inactive Cas9 (dCas9): a new tool for genetic engineering in Leptospira

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09 Jan 2019
publication

A public database for the new MLST scheme for subsp. : surveillance and epidemiology of the causative agent of syphilis

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26 Sep 2018
publication

An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins

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13 Sep 2018
publication

Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis

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01 Sep 2018
publication

An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins

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10 Aug 2018
publication

International Committee on Systematics of Prokaryotes Subcommittee on the Taxonomy of Leptospiraceae. Minutes of the closed meeting, 28 November 2017, Palmerston North, New Zealand

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06 Aug 2018
publication

Characterization of LE3 and LE4, the only lytic phages known to infect the spirochete Leptospira

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01 Aug 2018
publication

Leptospirosis as Cause of Febrile Icteric Illness, Burkina Faso

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19 Jul 2018
publication

Epidemiology of Human Leptospirosis in French Guiana (2007-2014): A Retrospective Study

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19 Jun 2018
publication

Genomic Comparison Among Global Isolates of Serovars Copenhageni and Icterohaemorrhagiae Identified Natural Genetic Variation Caused by an Indel

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08 May 2018
publication

FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete

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01 May 2018
publication

Biodiversity of Environmental : Improving Identification and Revisiting the Diagnosis

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06 Apr 2018
publication

The sigma factor σ is required for the long-term survival of Leptospira biflexa in water

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23 Feb 2018
publication

Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic

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14 Feb 2018
event

“Regulatory networks that control the Lyme Borreliosis spirochete’s infectious cycle”

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03 Jan 2018
publication

Deciphering the unexplored Leptospira diversity from soils uncovers genomic evolution to virulence

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03 Jan 2018
publication

Antibiotic susceptibilities of livestock isolates of leptospira

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14 Dec 2017
publication

Leptospira venezuelensis sp. nov., a new member of the intermediate group isolated from rodents, cattle and humans

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06 Dec 2017
publication

LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition

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01 Oct 2017
publication

Pet rodents as possible risk for leptospirosis, Belgium and France, 2009 to 2016

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29 Aug 2017
publication

Toolbox of Molecular Techniques for Studying Leptospira Spp

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06 May 2017
publication

[Leptospirosis in French Guiana and the Guiana shield: Current knowledge in 2016]

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06 Mar 2017
publication

Virulence of the zoonotic agent of leptospirosis: still terra incognita?

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21 Feb 2017
publication

Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis

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19 Jan 2017
publication

Genome-Wide Transcriptional Start Site Mapping and sRNA Identification in the Pathogen Leptospira interrogans

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17 Jan 2017
publication

The EbpA-RpoN Regulatory Pathway of the Pathogen Leptospira interrogans Is Essential for Survival in the Environment

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02 May 2016
publication

Real-time PCR reveals rapid dissemination of Leptospira interrogans after intraperitoneal and conjunctival inoculation of hamsters

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29 Apr 2016
publication

Underestimation of Leptospirosis Incidence in the French West Indies

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26 Apr 2016
publication

A novel flagellar sheath protein, FcpA, determines filament coiling, translational motility and virulence for the Leptospira spirochete

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04 Apr 2016
publication

Analysis of a Spontaneous Non-Motile and Avirulent Mutant Shows That FliM Is Required for Full Endoflagella Assembly in Leptospira interrogans

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04 Apr 2016
publication

Estimating the Burden of Leptospirosis among Febrile Subjects Aged below 20 Years in Kampong Cham Communities, Cambodia, 2007-2009

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11 Mar 2016
publication

Acquisition of negative complement regulators by the saprophyte Leptospira biflexa expressing LigA or LigB confers enhanced survival in human serum

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23 Feb 2016
publication

Molecular analysis of leptospires from serogroup Sejroe obtained from asymptomatic cattle in Rio de Janeiro – Brazil reveals genetic proximity to serovar Guaricura

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18 Feb 2016
publication

What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

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25 Jan 2016
publication

Erratum for Eshghi et al., Leptospira interrogans lpxD Homologue Is Required for Thermal Acclimatization and Virulence

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04 Dec 2015
publication

International Committee on Systematics of ProkaryotesSubcommittee on the taxonomy of LeptospiraceaeMinutes of the closed meeting, 8 October 2015, Semarang, Indonesia

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01 Dec 2015
publication

Factors Associated with Severe Leptospirosis, Martinique, 2010-2013

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05 Oct 2015
publication

Urban Market Gardening and Rodent-Borne Pathogenic Leptospira in Arid Zones: A Case Study in Niamey, Niger

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24 Sep 2015
publication

Leptospirosis: Updating the Global Picture of an Emerging Neglected Disease

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10 Sep 2015
publication

Molecular Characterization and Serology of Leptospira kirschneri (Serogroup Grippotyphosa) Isolated from Urine of a Mare Post-Abortion in Brazil

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01 Sep 2015
publication

Control of gene expression in Leptospira spp. by Transcription Activator-Like Effectors (TALEs) demonstrates a potential role for LigA and LigB in virulence in L. interrogans.

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25 Aug 2015
project

Expanding the toolbox for genetic manipulation of Leptospira spp.

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20 Aug 2015
project

Phenotypic characterization of transposon mutants in the pathogen L. interrogans

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15 Aug 2015
project

Cell morphology and motility in Leptospira spp.

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10 Aug 2015
project

Exoproteins and Leucin-Rich Repeat (LRR) proteins in Leptospira spp.

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01 Aug 2015
publication

Leptospira interrogans lpxD Homologue is Required for Thermal Acclimatization and Virulence.

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27 Jul 2015
nrc

Leptospirosis

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27 Jul 2015
publication

Investigation of a leptospirosis outbreak in triathlon participants, Réunion Island, 2013

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25 Jul 2015
project

Development and evaluation of rapid diagnostic tests on leptospirosis

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08 Jul 2015
publication

Use of a New High Resolution Melting Method for Genotyping Pathogenic Leptospira spp

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06 Jul 2015
publication

Molecular characterization of Leptospira sp by multilocus variable number tandem repeat analysis (MLVA) from clinical samples: a case report

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04 Jul 2015
project

Molecular and serological investigations on leptospirosis

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01 Jul 2015
publication

Neutrophil Extracellular Traps are Involved in the Innate Immune Response to Infection with Leptospira.

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23 May 2015
publication

Structural characterization of a novel subfamily of leucine-rich repeat proteins from the human pathogen Leptospira interrogans

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18 May 2015
publication

Pathogenic Leptospira interrogans Exoproteins Are Primarily Involved in Heterotrophic Processes

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11 May 2015
team

Biology of Spirochetes

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27 Feb 2015
publication

A replicative plasmid vector allows efficient complementation of pathogenic Leptospira strains

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26 Feb 2015
publication

A multilocus variable number tandem repeat analysis assay provides high discrimination for genotyping Leptospira santarosai strains

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01 Jan 2015
publication

Genomics, proteomics, and genetics of leptospira

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11 Dec 2014
publication

Gene inactivation of a chemotaxis operon in the pathogen Leptospira interrogans

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04 Dec 2014
publication

Live imaging of bioluminescent leptospira interrogans in mice reveals renal colonization as a stealth escape from the blood defenses and antibiotics

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01 Dec 2014
publication

Leptospira mayottensis sp. nov., a pathogenic species of the genus Leptospira isolated from humans.

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23 Sep 2014
publication

Leptospira mayottensis sp. nov., a pathogenic species of the genus Leptospira isolated from humans

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15 Sep 2014
publication

HemR is an OmpR/PhoB-like response regulator from Leptospira, which simultaneously effects transcriptional activation and repression of key haem metabolism genes

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04 Sep 2014
publication

First isolation of Leptospira noguchii serogroups Panama and Autumnalis from cattle

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25 Jul 2014
publication

Screening of a Leptospira biflexa mutant library to identify genes involved in ethidium bromide tolerance

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05 Jun 2014
publication

Epidemiology of leptospira transmitted by rodents in southeast Asia

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31 Mar 2014
publication

A putative regulatory genetic locus modulates virulence in the pathogen Leptospira interrogans

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11 Oct 2013
publication

Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp

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01 Oct 2013
publication

Rapid tests for diagnosis of leptospirosis: current tools and emerging technologies

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27 Jun 2013
publication

Sensitivity and Specificity of a New Vertical Flow Rapid Diagnostic Test for the Serodiagnosis of Human Leptospirosis

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14 Mar 2013
publication

Evaluation of an in-house ELISA using the intermediate species Leptospira fainei for diagnosis of leptospirosis

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14 Mar 2013
publication

Serovar diversity of pathogenic Leptospira circulating in the French West Indies

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21 Sep 2012
publication

Chemotactic behavior of pathogenic and nonpathogenic Leptospira species

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26 Mar 2012
publication

FlaA proteins in Leptospira interrogans are essential for motility and virulence but are not required for formation of the flagellum sheath

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01 Jan 2012
publication

Construction of a library of random mutants in the spirochete Leptospira biflexa using a mariner transposon

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16 Sep 2011
publication

Deciphering morphological determinants of the helix-shaped Leptospira

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05 Jul 2011
publication

Inactivation of clpB in the pathogen Leptospira interrogans reduces virulence and resistance to stress conditions

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09 Jun 2011
publication

Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin

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06 Apr 2011
publication

Comparison of real-time PCR assays for detection of pathogenic Leptospira spp. in blood and identification of variations in target sequences

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29 Oct 2010
publication

Expanding the genetic toolbox for Leptospira species by generation of fluorescent bacteria

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22 Jun 2010
publication

Isolation and characterization of new Leptospira genotypes from patients in Mayotte (Indian Ocean)

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28 May 2010
publication

Antibiotic resistance markers for genetic manipulations of Leptospira spp

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13 Sep 2009
publication

Transposition of fly mariner elements into bacteria as a genetic tool for mutagenesis

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01 May 2009
publication

Use of quantitative real-time PCR for studying the dissemination of Leptospira interrogans in the guinea pig infection model of leptospirosis

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01 May 2008
publication

Biofilm formation by saprophytic and pathogenic leptospires

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13 Feb 2008
publication

Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis

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30 Jan 2008
publication

Heme rescues a two-component system Leptospira biflexa mutant

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09 Nov 2007
publication

Conjugative transfer between Escherichia coli and Leptospira spp. as a new genetic tool

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01 Jul 2007
publication

The OmpA-like protein Loa22 is essential for leptospiral virulence

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01 Jun 2007
publication

Genetic manipulation of Leptospira biflexa

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21 Nov 2006
publication

A genomic island of the pathogen Leptospira interrogans serovar Lai can excise from its chromosome

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01 Nov 2006
publication

Application of multilocus variable-number tandem-repeat analysis for molecular typing of the agent of leptospirosis

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01 Jan 2006
publication

The scc spirochetal coiled-coil protein forms helix-like filaments and binds to nucleic acids generating nucleoprotein structures

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01 Jun 2005
publication

Complete nucleotide sequence of the LE1 prophage from the spirochete Leptospira biflexa and characterization of its replication and partition functions

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01 May 2005
publication

Random insertional mutagenesis of Leptospira interrogans, the agent of leptospirosis, using a mariner transposon

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01 May 2005
publication

Isolation and characterization of FecA- and FeoB-mediated iron acquisition systems of the spirochete Leptospira biflexa by random insertional mutagenesis

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12 Dec 2003
publication

The spirochetal chpK-chromosomal toxin-antitoxin locus induces growth inhibition of yeast and mycobacteria

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29 Aug 2003
publication

Genetic evidence for the existence of two pathways for the biosynthesis of methionine in the Leptospira spp

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01 Aug 2003
publication

Leptospira spp. possess a complete haem biosynthetic pathway and are able to use exogenous haem sources

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01 Mar 2003
publication

Construction and complementation of the first auxotrophic mutant in the spirochaete Leptospira meyeri

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01 Jan 2002
publication

Inactivation of the spirochete recA gene results in a mutant with low viability and irregular nucleoid morphology

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