Ligne de temps
Mathieu Picardeau
Responsable de Structure
04 avr. 2024
publication
Inter-species transcriptomic analysis reveals a constitutive adaptation against oxidative stress for the highly virulent Leptospira species.
Lire plus01 févr. 2024
01 déc. 2023
publication
Core genome sequencing and genotyping of Leptospira interrogans in clinical samples by target capture sequencing
Lire plus01 nov. 2023
publication
Histones with an unconventional DNA-binding mode in vitro are major chromatin constituents in the bacterium Bdellovibrio bacteriovorus.
Lire plus01 nov. 2023
publication
Phylogenomics of Leptospira santarosai, a prevalent pathogenic species in the Americas.
Lire plus12 oct. 2023
29 août 2023
event
Microbiology departement seminar : Brandon Jutras (Virginia Tech, Blacksburg, USA) ; Friday, September 15th @11.30am ; Auditorium F.Jacob
Lire plus14 mars 2023
publication
Core genome sequencing and genotyping of Leptospira interrogans in clinical samples by target capture sequencing.
Lire plus01 févr. 2023
publication
Horizontal transfer of the rfb cluster in Leptospira is a genetic determinant of serovar identity.
Lire plus01 janv. 2023
01 janv. 2023
publication
Genetic diversity of Leptospira strains circulating in humans and dogs in France in 2019-2021.
Lire plus13 oct. 2022
01 août 2022
publication
Zoonoses and gold mining: A cross-sectional study to assess yellow fever immunization, Q fever, leptospirosis and leishmaniasis among the population working on illegal mining camps in French Guiana.
Lire plus11 juil. 2022
01 janv. 2022
publication
Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagella.
Lire plus13 déc. 2021
publication
Investigating the role of the carbon storage regulator A (CsrA) Leptospira spp.
Lire plus01 déc. 2021
publication
Genetic diversity of Leptospira isolates in Lao PDR and genome analysis of an outbreak strain.
Lire plus01 déc. 2021
publication
The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence.
Lire plus01 déc. 2021
publication
Leptospira ainlahdjerensis sp. nov., Leptospira ainazelensis sp. nov., Leptospira abararensis sp. nov. and Leptospira chreensis sp. nov., four new species isolated from water sources in Algeria.
Lire plus01 déc. 2021
publication
The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of Leptospira interrogans.
Lire plus17 oct. 2021
publication
Role of the major determinant of polar flagellation FlhG in the endoflagella-containing spirochete Leptospira.
Lire plus01 oct. 2021
01 août 2021
publication
International Committee on Systematics of Prokaryotes Subcommittee on the taxonomy of Leptospiraceae Minutes of the closed meeting, 10 July 2019, Vancouver, British Columbia, Canada.
Lire plus01 juin 2021
publication
Ending the Neglect of Treatable Bacterial Zoonoses Responsible for Non-Malaria Fevers.
Lire plus01 mai 2021
publication
Correction: 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka.
Lire plus23 févr. 2021
publication
Leptospira dzianensis and Leptospira putramalaysiae are later heterotypic synonyms of Leptospira yasudae and Leptospira stimsonii.
Lire plus03 févr. 2021
publication
Pathogenic Leptospira and water quality in African cities: A case study of Cotonou, Benin.
Lire plus01 janv. 2021
publication
Effect of disinfection agents and quantification of potentially viable Leptospira in fresh water samples using a highly sensitive integrity-qPCR assay.
Lire plus01 janv. 2021
publication
Investigating the role of the carbon storage regulator A (CsrA) in Leptospira spp.
Lire plus02 déc. 2020
publication
4-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen Leptospira interrogans.
Lire plus26 nov. 2020
06 oct. 2020
publication
The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress.
Lire plus01 sept. 2020
publication
Circulating genotypes of Leptospira in French Polynesia : An 9-year molecular epidemiology surveillance follow-up study.
Lire plus01 août 2020
publication
Correction: Genus-wide Leptospira core genome multilocus sequence typing for strain taxonomy and global surveillance.
Lire plus01 août 2020
01 juil. 2020
publication
Isolation of Leptospira interrogans from a Bottlenose Dolphin (Tursiops truncatus) in the Mediterranean Sea.
Lire plus12 juin 2020
publication
The zoonotic pathogen Leptospira interrogans mitigates environmental stress through cyclic-di-GMP-controlled biofilm production.
Lire plus11 mars 2020
publication
An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete.
Lire plus01 janv. 2020
publication
Core Genome Multi-locus Sequence Typing Analyses of Leptospira spp. Using the Bacterial Isolate Genome Sequence Database.
Lire plus01 janv. 2020
01 janv. 2020
publication
A first insight into the genomic diversity of Leptospira strains isolated from patients in Cuba.
Lire plus01 janv. 2020
01 janv. 2020
publication
Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.
Lire plus01 janv. 2020
01 déc. 2019
publication
Severe leptospirosis in non-tropical areas: a nationwide, multicentre, retrospective study in French ICUs.
Lire plus01 sept. 2019
publication
Usefulness of C-Reactive Protein in Differentiating Acute Leptospirosis and Dengue Fever in French Guiana.
Lire plus31 juil. 2019
publication
Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens
Lire plus01 juin 2019
publication
Leptospirosis under the bibliometrics radar: evidence for a vicious circle of neglect
Lire plus01 mai 2019
publication
Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics.
Lire plus01 mai 2019
publication
High Prevalence of Leptospira spp. in Rodents in an Urban Setting in Madagascar.
Lire plus01 avr. 2019
publication
Genus-wide Leptospira core genome multilocus sequence typing for strain taxonomy and global surveillance.
Lire plus12 févr. 2019
publication
Gene silencing based on RNA-guided catalytically inactive Cas9 (dCas9): a new tool for genetic engineering in Leptospira
Lire plus09 janv. 2019
publication
A public database for the new MLST scheme for subsp. : surveillance and epidemiology of the causative agent of syphilis
Lire plus01 nov. 2018
publication
An outbreak of leptospirosis among kayakers in Brittany, North-West France, 2016.
Lire plus26 sept. 2018
publication
An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins
Lire plus13 sept. 2018
publication
Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis
Lire plus01 sept. 2018
publication
An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins
Lire plus10 août 2018
publication
International Committee on Systematics of Prokaryotes Subcommittee on the Taxonomy of Leptospiraceae. Minutes of the closed meeting, 28 November 2017, Palmerston North, New Zealand
Lire plus06 août 2018
publication
Characterization of LE3 and LE4, the only lytic phages known to infect the spirochete Leptospira.
Lire plus01 août 2018
19 juil. 2018
publication
Epidemiology of Human Leptospirosis in French Guiana (2007-2014): A Retrospective Study
Lire plus19 juin 2018
publication
Genomic Comparison Among Global Isolates of Serovars Copenhageni and Icterohaemorrhagiae Identified Natural Genetic Variation Caused by an Indel
Lire plus08 mai 2018
publication
FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete
Lire plus01 mai 2018
publication
Biodiversity of Environmental : Improving Identification and Revisiting the Diagnosis
Lire plus06 avr. 2018
publication
The sigma factor σ is required for the long-term survival of Leptospira biflexa in water
Lire plus23 févr. 2018
publication
Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic
Lire plus14 févr. 2018
event
“Regulatory networks that control the Lyme Borreliosis spirochete’s infectious cycle”
Lire plus01 févr. 2018
publication
Leptospira venezuelensis sp. nov., a new member of the intermediate group isolated from rodents, cattle and humans.
Lire plus12 janv. 2018
publication
Structure and function of the Leptospira interrogans peroxide stress regulator (PerR), an atypical PerR devoid of a structural metal-binding site.
Lire plus03 janv. 2018
publication
Deciphering the unexplored Leptospira diversity from soils uncovers genomic evolution to virulence
Lire plus03 janv. 2018
01 déc. 2017
publication
LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition.
Lire plus01 déc. 2017
publication
Correction: Underestimation of Leptospirosis Incidence in the French West Indies.
Lire plus01 oct. 2017
publication
Pet rodents as possible risk for leptospirosis, Belgium and France, 2009 to 2016
Lire plus01 août 2017
publication
[Leptospirosis in French Guiana and the Guiana shield: Current knowledge in 2016].
Lire plus01 août 2017
publication
Isolation by culture and PCR identification of LipL32 gene of pathogenic Leptospira spp. in wild rats of Kuala Lumpur.
Lire plus01 juin 2017
publication
Evaluation of different serological assays for early diagnosis of leptospirosis in Martinique (French West Indies).
Lire plus06 mars 2017
21 févr. 2017
publication
Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis
Lire plus01 févr. 2017
publication
Diagnostic accuracy of an in-house ELISA using the intermediate species Leptospira fainei as antigen for diagnosis of acute leptospirosis in dogs.
Lire plus19 janv. 2017
publication
Genome-Wide Transcriptional Start Site Mapping and sRNA Identification in the Pathogen Leptospira interrogans
Lire plus17 janv. 2017
publication
The EbpA-RpoN Regulatory Pathway of the Pathogen Leptospira interrogans Is Essential for Survival in the Environment
Lire plus01 janv. 2017
publication
Population genetics, community of parasites, and resistance to rodenticides in an urban brown rat (Rattus norvegicus) population
Lire plus02 mai 2016
publication
Real-time PCR reveals rapid dissemination of Leptospira interrogans after intraperitoneal and conjunctival inoculation of hamsters
Lire plus29 avr. 2016
26 avr. 2016
publication
A novel flagellar sheath protein, FcpA, determines filament coiling, translational motility and virulence for the Leptospira spirochete
Lire plus04 avr. 2016
publication
Analysis of a Spontaneous Non-Motile and Avirulent Mutant Shows That FliM Is Required for Full Endoflagella Assembly in Leptospira interrogans
Lire plus04 avr. 2016
publication
Estimating the Burden of Leptospirosis among Febrile Subjects Aged below 20 Years in Kampong Cham Communities, Cambodia, 2007-2009
Lire plus01 avr. 2016
publication
Molecular analysis of leptospires from serogroup Sejroe obtained from asymptomatic cattle in Rio de Janeiro – Brazil reveals genetic proximity to serovar Guaricura.
Lire plus11 mars 2016
publication
Acquisition of negative complement regulators by the saprophyte Leptospira biflexa expressing LigA or LigB confers enhanced survival in human serum
Lire plus18 févr. 2016
publication
What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
Lire plus25 janv. 2016
publication
Erratum for Eshghi et al., Leptospira interrogans lpxD Homologue Is Required for Thermal Acclimatization and Virulence
Lire plus04 déc. 2015
publication
International Committee on Systematics of ProkaryotesSubcommittee on the taxonomy of LeptospiraceaeMinutes of the closed meeting, 8 October 2015, Semarang, Indonesia
Lire plus01 déc. 2015
05 oct. 2015
publication
Urban Market Gardening and Rodent-Borne Pathogenic Leptospira in Arid Zones: A Case Study in Niamey, Niger
Lire plus24 sept. 2015
10 sept. 2015
publication
Molecular Characterization and Serology of Leptospira kirschneri (Serogroup Grippotyphosa) Isolated from Urine of a Mare Post-Abortion in Brazil.
Lire plus01 sept. 2015
publication
Control of gene expression in Leptospira spp. by Transcription Activator-Like Effectors (TALEs) demonstrates a potential role for LigA and LigB in virulence in L. interrogans.
Lire plus31 août 2015
project
Genomic taxonomy of bacterial strains: universal nomenclatures for epidemiology and population biology
Lire plus25 août 2015
15 août 2015
01 août 2015
publication
Leptospira interrogans lpxD Homologue is Required for Thermal Acclimatization and Virulence.
Lire plus27 juil. 2015
27 juil. 2015
publication
Investigation of a leptospirosis outbreak in triathlon participants, Réunion Island, 2013
Lire plus08 juil. 2015
publication
Use of a New High Resolution Melting Method for Genotyping Pathogenic Leptospira spp
Lire plus06 juil. 2015
publication
Molecular characterization of Leptospira sp by multilocus variable number tandem repeat analysis (MLVA) from clinical samples: a case report
Lire plus04 juil. 2015
01 juil. 2015
publication
Neutrophil Extracellular Traps are Involved in the Innate Immune Response to Infection with Leptospira.
Lire plus23 mai 2015
publication
Structural characterization of a novel subfamily of leucine-rich repeat proteins from the human pathogen Leptospira interrogans
Lire plus18 mai 2015
publication
Pathogenic Leptospira interrogans Exoproteins Are Primarily Involved in Heterotrophic Processes
Lire plus11 mai 2015
27 févr. 2015
publication
A replicative plasmid vector allows efficient complementation of pathogenic Leptospira strains
Lire plus26 févr. 2015
publication
A multilocus variable number tandem repeat analysis assay provides high discrimination for genotyping Leptospira santarosai strains
Lire plus01 janv. 2015
11 déc. 2014
publication
Gene inactivation of a chemotaxis operon in the pathogen Leptospira interrogans
Lire plus01 déc. 2014
publication
Leptospira mayottensis sp. nov., a pathogenic species of the genus Leptospira isolated from humans.
Lire plus23 sept. 2014
publication
Leptospira mayottensis sp. nov., a pathogenic species of the genus Leptospira isolated from humans
Lire plus15 sept. 2014
publication
HemR is an OmpR/PhoB-like response regulator from Leptospira, which simultaneously effects transcriptional activation and repression of key haem metabolism genes
Lire plus04 sept. 2014
publication
First isolation of Leptospira noguchii serogroups Panama and Autumnalis from cattle
Lire plus25 juil. 2014
publication
Screening of a Leptospira biflexa mutant library to identify genes involved in ethidium bromide tolerance
Lire plus05 juin 2014
31 mars 2014
publication
A putative regulatory genetic locus modulates virulence in the pathogen Leptospira interrogans
Lire plus01 janv. 2014
publication
Molecular characterization of the first leptospires isolated from goats in Brazil.
Lire plus11 oct. 2013
publication
Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp
Lire plus01 oct. 2013
publication
Rapid tests for diagnosis of leptospirosis: current tools and emerging technologies
Lire plus14 mars 2013
publication
Serovar diversity of pathogenic Leptospira circulating in the French West Indies
Lire plus14 mars 2013
publication
Evaluation of an in-house ELISA using the intermediate species Leptospira fainei for diagnosis of leptospirosis
Lire plus21 sept. 2012
26 mars 2012
publication
FlaA proteins in Leptospira interrogans are essential for motility and virulence but are not required for formation of the flagellum sheath
Lire plus01 janv. 2012
publication
Construction of a library of random mutants in the spirochete Leptospira biflexa using a mariner transposon
Lire plus16 sept. 2011
05 juil. 2011
publication
Inactivation of clpB in the pathogen Leptospira interrogans reduces virulence and resistance to stress conditions
Lire plus09 juin 2011
publication
Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin
Lire plus06 avr. 2011
publication
Comparison of real-time PCR assays for detection of pathogenic Leptospira spp. in blood and identification of variations in target sequences
Lire plus29 oct. 2010
publication
Expanding the genetic toolbox for Leptospira species by generation of fluorescent bacteria
Lire plus22 juin 2010
publication
Isolation and characterization of new Leptospira genotypes from patients in Mayotte (Indian Ocean)
Lire plus28 mai 2010
13 sept. 2009
publication
Transposition of fly mariner elements into bacteria as a genetic tool for mutagenesis
Lire plus01 mai 2009
publication
Use of quantitative real-time PCR for studying the dissemination of Leptospira interrogans in the guinea pig infection model of leptospirosis
Lire plus01 mai 2008
13 févr. 2008
publication
Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis
Lire plus30 janv. 2008
09 nov. 2007
publication
Conjugative transfer between Escherichia coli and Leptospira spp. as a new genetic tool
Lire plus01 juil. 2007
01 juin 2007
21 nov. 2006
publication
A genomic island of the pathogen Leptospira interrogans serovar Lai can excise from its chromosome
Lire plus01 nov. 2006
publication
Application of multilocus variable-number tandem-repeat analysis for molecular typing of the agent of leptospirosis
Lire plus01 janv. 2006
publication
The scc spirochetal coiled-coil protein forms helix-like filaments and binds to nucleic acids generating nucleoprotein structures
Lire plus01 juin 2005
publication
Complete nucleotide sequence of the LE1 prophage from the spirochete Leptospira biflexa and characterization of its replication and partition functions
Lire plus01 mai 2005
publication
Isolation and characterization of FecA- and FeoB-mediated iron acquisition systems of the spirochete Leptospira biflexa by random insertional mutagenesis
Lire plus01 mai 2005
publication
Random insertional mutagenesis of Leptospira interrogans, the agent of leptospirosis, using a mariner transposon
Lire plus12 déc. 2003
publication
The spirochetal chpK-chromosomal toxin-antitoxin locus induces growth inhibition of yeast and mycobacteria
Lire plus29 août 2003
publication
Genetic evidence for the existence of two pathways for the biosynthesis of methionine in the Leptospira spp
Lire plus01 août 2003
publication
Leptospira spp. possess a complete haem biosynthetic pathway and are able to use exogenous haem sources
Lire plus01 mars 2003
publication
Construction and complementation of the first auxotrophic mutant in the spirochaete Leptospira meyeri
Lire plus01 janv. 2002
publication