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© Research
Event

“Regulatory networks that control the Lyme Borreliosis spirochete’s infectious cycle”

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
16
Mar 2018
Time
11:30:00
25 Rue du Dr Roux, 75015 Paris, France
Address
Building: Centre François Jacob
Location
2018-03-16 11:30:00 2018-03-16 12:30:00 Europe/Paris “Regulatory networks that control the Lyme Borreliosis spirochete’s infectious cycle” The infectious cycle of Borrelia burgdorferi, the Lyme borreliosis spirochete, necessitates persistent infection of both vertebrates and ticks, and efficient means of transmission between those two very different types of hosts. Studies from our […] 25 Rue du Dr Roux, 75015 Paris, France Mathieu Picardeau mathieu.picardeau@pasteur.fr

About

The infectious cycle of Borrelia burgdorferi, the Lyme borreliosis spirochete, necessitates persistent infection of both vertebrates and ticks, and efficient means of transmission between those two very different types of hosts. Studies from our laboratory and others have identified numerous regulatory factors that B. burgdorferi uses to control gene and protein expression levels. To date, only one sensory system has been discovered that responds to external stimuli, while the majority of sensory proteins respond to internal signals. Noting that the infectious cycle of  B. burgdorferi always follows an identical route of tick-to-vertebrate-to-tick, etc., we hypothesize that the Lyme spirochete can accurately determine its position in the infectious cycle by sensing its own metabolic activity.

Location

Building: Centre François Jacob
Address: 25 Rue du Dr Roux, 75015 Paris, France