Follicular growth and ovarian endocrine function
In mammals, ovaries contain a definite number of follicles, each containing a germ cell, the oocyte. The production of fertilizable ovocytes involves complex molecular, cellular, paracrine and endocrine mechanisms and requires a growth phase […]
Epiblast/Primitive Endoderm specification and differentiation during early mouse development
The mammalian preimplantation embryo is a model of choice to study these processes and derivation of stem cells from early embryos has generated a lot of interest for this period of development. Mammalian development […]
Notch Activity Sensor (NAS) transgenic mouse line
Because of the various levels of regulation of the Notch pathway, its activity cannot be easily deduced from the expression profiles of its components. In order to visualize Notch activity in situ at the cellular level, […]
The H-2Z1 transgenic line
The H-2Z1 transgenic line which exhibits a striking and unexpected expression profile. In this line, lacZ expression in the cerebral cortex is restricted to a subset of layer IV neurons and delineates precisely the somatosensory area. We […]
2017Optimization of the production of knock-in alleles by CRISPR/Cas9 microinjection into the mouse zygote, Sci Rep 2017 Feb;7:42661.
2016Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network, Nat. Cell Biol. 2016 Oct;.
2015NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo, Development 2015 Nov;142(21):3649-60.
2015Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells, Cell Death Differ. 2015 Jun;.
2014Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells, Cell Death Differ. 2015 Jan;22(1):108-17.
2014Notchless is required for axial skeleton formation in mice, PLoS ONE 2014;9(5):e98507.
2013Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells, J. Exp. Med. 2013 Oct;210(11):2351-69.
2013PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst, Stem Cells 2013 Sep;31(9):1932-41.
2012I-SceI-mediated double-strand break does not increase the frequency of homologous recombination at the Dct locus in mouse embryonic stem cells, PLoS ONE 2012;7(6):e39895.
2012Omcg1 is critically required for mitosis in rapidly dividing mouse intestinal progenitors and embryonic stem cells, Biol Open 2012 Jul;1(7):648-57.
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