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  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
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  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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About

The emergence of discrete cell identities from undifferentiated precursor cells is a central process in development and tissue homeostasis and repair, that when defective is at the basis of many human conditions including cancer and aging. The goal of our research is to provide a better understanding of the regulations operating at the levels of both intrinsic programs and extrinsic cues to ensure acquisition and maintenance of cell identities in an in vivo context. We are using as a model of choice the mouse preimplantation embryo, for which in vivo cell fate decisions can be scrutinized with high spatiotemporal resolution thus allowing to probe how dynamic changes in spatial cues and gene expression program are resolved into distinct cell identities in the intact embryo. In mammals, placental viviparity imposes on embryo development to begin with the generation of extraembryonic lineages required to interact with the maternal tissues, namely trophectoderm (TE) and primitive endoderm (PrE), while preserving a small population of pluripotent epiblast (Epi) cells from which the embryo proper originates. Understanding how these three lineages are produced in the proportion and arrangement appropriate for post-implantation development to proceed is of paramount importance in the context of the continuous decline of human fertility and increasing use of medically assisted reproductive technologies.

Former Members

2000
2000
Name
Position
2015
2019
Tiphaine Aguirre Lavin
Technician
2015
2019
Jérôme Artus
PhD Student
2015
2019
Franck Coumailleau
Permanent Researcher
2015
2019
Marie Escande
Technician
2015
2019
Martin Houlard
Post-doc
2015
2019
Marie Le Bouteiller
PhD Student
2015
2019
Teddy Léguillier
PhD Student
2015
2019
Céline Souilhol
PhD Student
2015
2019
Aline Stedman
Post-doc
2015
2019
Miren Zuazo Ibarra
Master Student
2015
2019
Leonard Jarzebowski
PhD Student
2015
2019
Sylvain Bessonnard
Post-doc
2015
2019
Aurélien Raveux
PhD Student
2015
2019
Sabrina Coqueran
Technician
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Courses

Mouse Genetics Course

  This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […]

2022-01-03 09:00:00 2022-02-08 18:00:00 Europe/Paris Mouse Genetics Course   This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […] Institut Pasteur, Rue du Docteur Roux, Paris, France

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Contact

Phone: +331 45688486 Email:  m-cohen@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France