Embryon précoce de mammifères et cellules souches

In mammals, ovaries contain a definite number of follicles, each containing a germ cell, the oocyte. The production of fertilizable ovocytes involves complex molecular, cellular, paracrine and endocrine mechanisms and requires a growth phase […]

The mammalian preimplantation embryo is a model of choice to study these processes and derivation of stem cells from early embryos has generated a lot of interest for this period of development. Mammalian development […]

Because of the various levels of regulation of the Notch pathway, its activity cannot be easily deduced from the expression profiles of its components. In order to visualize Notch activity in situ at the cellular level, […]

      The H-2Z1 transgenic line which exhibits a striking and unexpected expression profile. In this line, lacZ expression in the cerebral cortex is restricted to a subset of layer IV neurons and delineates precisely […]