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  • Director of Center
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Courses

09:00
08
Jan 2018
Course

Mouse Genetics Course

This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. This […]
2018-01-08 09:00:00 2018-02-13 18:00:00 Europe/Paris Mouse Genetics Course This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. This […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Projects

project
Ongoing
2 Members

Follicular growth and ovarian endocrine function

Michel Cohen-Tannoudji (PI)

In mammals, ovaries contain a definite number of follicles, each containing a germ cell, the oocyte. The production of fertilizable ovocytes involves complex molecular, cellular, paracrine and endocrine mechanisms and requires a growth phase […]
project
Ongoing
6 Members

Epiblast/Primitive Endoderm specification and differentiation during early mouse development

Michel Cohen-Tannoudji (PI)

The mammalian preimplantation embryo is a model of choice to study these processes and derivation of stem cells from early embryos has generated a lot of interest for this period of development. Mammalian development […]
project
Ongoing
9 Members

Inheritance of the pluripotency network’s activity

Pablo Navarro Gil (PI)

The preservation of pluripotency throughout cell division – self-renewal -, is strictly dependent on the highly efficient action of the pluripotency gene regulatory network. However, how TFs cope with replication and mitosis, two major […]
project
Ongoing
4 Members

The epigenetic foundation of gene expression heterogeneity

Pablo Navarro Gil (PI)

Self-renewing ES cells display dramatic cell-to-cell variability in the expression level of key transcription factors such as Nanog. Whereas Nanog-positive cells self-renew efficiently, Nanog-negative cells are prone to differentiate. Although these two populations can dynamically inter-convert, very […]

Tools

tool
Ongoing
4 Members

Notch Activity Sensor (NAS) transgenic mouse line

Michel Cohen-Tannoudji (PI)

Because of the various levels of regulation of the Notch pathway, its activity cannot be easily deduced from the expression profiles of its components. In order to visualize Notch activity in situ at the cellular level, […]
tool
Completed
2 Members

The H-2Z1 transgenic line

Michel Cohen-Tannoudji (PI)

      The H-2Z1 transgenic line which exhibits a striking and unexpected expression profile. In this line, lacZ expression in the cerebral cortex is restricted to a subset of layer IV neurons and delineates precisely […]

Publications

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