Michel Cohen-Tannoudji - Research - Institut Pasteur

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Clinical Research Assistant
Clinical Research Nurse
Clinician Researcher
Department Manager
Dual-education Student
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Honorary Professor
Lab assistant
Master Student
MD-PhD Student
Medical Staff
Non-permanent Researcher
Nursing Staff
Permanent Researcher
Pharmacist
PhD Student
Physician
Post-doc
Prize
Project Manager
Research Associate
Research Engineer
Retired scientist
Technician
Undergraduate Student
Veterinary
Visiting Scientist

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Deputy Director of Center
Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

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Nathalie Duclert-Savatier

Frédérique Michel

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77 Publications

About

The emergence of discrete cell identities from undifferentiated precursor cells is a central process in development and tissue homeostasis and repair, that when defective is at the basis of many human conditions including cancer and aging. The goal of our research is to provide a better understanding of the regulations operating at the levels of both intrinsic programs and extrinsic cues to ensure acquisition and maintenance of cell identities in an in vivo context. We are using as a model of choice the mouse preimplantation embryo, for which in vivo cell fate decisions can be scrutinized with high spatiotemporal resolution thus allowing to probe how dynamic changes in spatial cues and gene expression program are resolved into distinct cell identities in the intact embryo. In mammals, placental viviparity imposes on embryo development to begin with the generation of extraembryonic lineages required to interact with the maternal tissues, namely trophectoderm (TE) and primitive endoderm (PrE), while preserving a small population of pluripotent epiblast (Epi) cells from which the embryo proper originates. Understanding how these three lineages are produced in the proportion and arrangement appropriate for post-implantation development to proceed is of paramount importance in the context of the continuous decline of human fertility and increasing use of medically assisted reproductive technologies.

Courses

Pasteur Course Mouse genetics for disease modelling

This five-week intensive course, featuring both laboratory work and lectures, explores the analysis of gene function at multiple levels: from the gene and its product, to the cell and its interactions, to embryonic tissues […]

Early Mammalian Development & Stem Cell Biology

Stem Cells And Development

Michel Cohen-Tannoudji

Xavier Montagutelli

Virginie Ponticelli

2026-01-05 21:00:00 2026-02-13 18:00:00 Europe/Paris Pasteur Course Mouse genetics for disease modelling This five-week intensive course, featuring both laboratory work and lectures, explores the analysis of gene function at multiple levels: from the gene and its product, to the cell and its interactions, to embryonic tissues […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Mouse Genetics for Disease Modelling Course

This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. This […]

Early Mammalian Development & Stem Cell Biology

Epigenomics, Proliferation and the Identity of Cells – EPIC

Developmental and Stem Cell Biology

Genomes and Genetics

Xavier Montagutelli

Michel Cohen-Tannoudji

2024-01-08 09:00:00 2024-02-13 18:00:00 Europe/Paris Mouse Genetics for Disease Modelling Course This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. This […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Transversal Projects

LabEx Revive – Regenerative biology & medicine

Rationale and Objectives of Revive Consortium Major advancements in stem cell biology have paved the way for concerted research activities on the fundamental biology of stem cells and their applications in the clinic. The […]

Projects

ERC-2017-COG_BinD – Mitotic Bookmarking, Stem Cells and early Development

Pablo Navarro Gil (PI)

The goal of this project is to deliver a new theoretical framework to understand how transcription factors (TFs) sustain cell identity during developmental processes. Recognised as key drivers of cell fate acquisition, TFs are […]

Follicular growth and ovarian endocrine function

Michel Cohen-Tannoudji (PI)

In mammals, ovaries contain a definite number of follicles, each containing a germ cell, the oocyte. The production of fertilizable ovocytes involves complex molecular, cellular, paracrine and endocrine mechanisms and requires a growth phase […]

Epiblast/Primitive Endoderm specification and differentiation during early mouse development

Michel Cohen-Tannoudji (PI)

The mammalian preimplantation embryo is a model of choice to study these processes and derivation of stem cells from early embryos has generated a lot of interest for this period of development. Mammalian development […]

Inheritance of the pluripotency network’s activity

Pablo Navarro Gil (PI)

The preservation of pluripotency throughout cell division – self-renewal -, is strictly dependent on the highly efficient action of the pluripotency gene regulatory network. However, how TFs cope with replication and mitosis, two major […]

The epigenetic foundation of gene expression heterogeneity

Pablo Navarro Gil (PI)

Self-renewing ES cells display dramatic cell-to-cell variability in the expression level of key transcription factors such as Nanog. Whereas Nanog-positive cells self-renew efficiently, Nanog-negative cells are prone to differentiate. Although these two populations can dynamically inter-convert, very […]

Tools

Notch Activity Sensor (NAS) transgenic mouse line

Michel Cohen-Tannoudji (PI)

Because of the various levels of regulation of the Notch pathway, its activity cannot be easily deduced from the expression profiles of its components. In order to visualize Notch activity in situ at the cellular level, […]

The H-2Z1 transgenic line

Michel Cohen-Tannoudji (PI)

The H-2Z1 transgenic line which exhibits a striking and unexpected expression profile. In this line, lacZ expression in the cerebral cortex is restricted to a subset of layer IV neurons and delineates precisely […]

Publications

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Published on: 11 May 2015 • Modified on: 19 Sep 2022