Mouse Genetics Course
This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. This […]
Follicular growth and ovarian endocrine function
In mammals, ovaries contain a definite number of follicles, each containing a germ cell, the oocyte. The production of fertilizable ovocytes involves complex molecular, cellular, paracrine and endocrine mechanisms and requires a growth phase […]
Epiblast/Primitive Endoderm specification and differentiation during early mouse development
The mammalian preimplantation embryo is a model of choice to study these processes and derivation of stem cells from early embryos has generated a lot of interest for this period of development. Mammalian development […]
Notch Activity Sensor (NAS) transgenic mouse line
Because of the various levels of regulation of the Notch pathway, its activity cannot be easily deduced from the expression profiles of its components. In order to visualize Notch activity in situ at the cellular level, […]
2018Notchless defines a stage-specific requirement for ribosome biogenesis during lineage progression in adult skeletal myogenesis, Development 2018 Nov;145(23).
2018Mouse adult hematopoietic stem cells actively synthetize ribosomal RNA, RNA 2018 Sep;.
2018Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells, Stem Cell Reports 2018 Jan;.
2017ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation, Sci Rep 2017 Sep;7(1):12285.
2017A multiscale model of early cell lineage specification including cell division, Npj Systems Biology and Applications, 3(1), 16..
2017A multiscale model of early cell lineage specification including cell division, NPJ Syst Biol Appl 2017;3:16.
2017Optimization of the production of knock-in alleles by CRISPR/Cas9 microinjection into the mouse zygote, Sci Rep 2017 Feb;7:42661.
2016Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network, Nat. Cell Biol. 2016 Oct;.
2015NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo, Development 2015 Nov;142(21):3649-60.
2015Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells, Cell Death Differ. 2015 Jun;.
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