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  • Physician
  • Post-doc
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  • Research Engineer
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  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
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  • Director of Center
  • Director of Department
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About

The emergence of discrete cell identities from undifferentiated precursor cells is a central process in development and tissue homeostasis and repair, that when defective is at the basis of many human conditions including cancer and aging. The goal of our research is to provide a better understanding of the regulations operating at the levels of both intrinsic programs and extrinsic cues to ensure acquisition and maintenance of cell identities in an in vivo context. We are using as a model of choice the mouse preimplantation embryo, for which in vivo cell fate decisions can be scrutinized with high spatiotemporal resolution thus allowing to probe how dynamic changes in spatial cues and gene expression program are resolved into distinct cell identities in the intact embryo. In mammals, placental viviparity imposes on embryo development to begin with the generation of extraembryonic lineages required to interact with the maternal tissues, namely trophectoderm (TE) and primitive endoderm (PrE), while preserving a small population of pluripotent epiblast (Epi) cells from which the embryo proper originates. Understanding how these three lineages are produced in the proportion and arrangement appropriate for post-implantation development to proceed is of paramount importance in the context of the continuous decline of human fertility and increasing use of medically assisted reproductive technologies.

Courses

09:00
08
Jan 2024
Course

Mouse Genetics Course

  This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […]
Mouse Genetics
Early Mammalian Development & Stem Cell Biology
Epigenomics, Proliferation and the Identity of Cells – EPIC
Developmental and Stem Cell Biology
Genomes and Genetics
Xavier Montagutelli
Michel Cohen-Tannoudji
2024-01-08 09:00:00 2024-02-13 18:00:00 Europe/Paris Mouse Genetics Course   This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Projects

Project
Ongoing
8 Members

ERC-2017-COG_BinD – Mitotic Bookmarking, Stem Cells and early Development

Pablo Navarro Gil (PI)

The goal of this project is to deliver a new theoretical framework to understand how transcription factors (TFs) sustain cell identity during developmental processes. Recognised as key drivers of cell fate acquisition, TFs are […]
Project
Ongoing
2 Members

Follicular growth and ovarian endocrine function

Michel Cohen-Tannoudji (PI)

In mammals, ovaries contain a definite number of follicles, each containing a germ cell, the oocyte. The production of fertilizable ovocytes involves complex molecular, cellular, paracrine and endocrine mechanisms and requires a growth phase […]
Project
Ongoing
6 Members

Epiblast/Primitive Endoderm specification and differentiation during early mouse development

Michel Cohen-Tannoudji (PI)

The mammalian preimplantation embryo is a model of choice to study these processes and derivation of stem cells from early embryos has generated a lot of interest for this period of development. Mammalian development […]
Project
Ongoing
9 Members

Inheritance of the pluripotency network’s activity

Pablo Navarro Gil (PI)

The preservation of pluripotency throughout cell division – self-renewal -, is strictly dependent on the highly efficient action of the pluripotency gene regulatory network. However, how TFs cope with replication and mitosis, two major […]
Project
Ongoing
4 Members

The epigenetic foundation of gene expression heterogeneity

Pablo Navarro Gil (PI)

Self-renewing ES cells display dramatic cell-to-cell variability in the expression level of key transcription factors such as Nanog. Whereas Nanog-positive cells self-renew efficiently, Nanog-negative cells are prone to differentiate. Although these two populations can dynamically inter-convert, very […]

Tools

Tool
Ongoing
4 Members

Notch Activity Sensor (NAS) transgenic mouse line

Michel Cohen-Tannoudji (PI)

Because of the various levels of regulation of the Notch pathway, its activity cannot be easily deduced from the expression profiles of its components. In order to visualize Notch activity in situ at the cellular level, […]
Tool
Completed
2 Members

The H-2Z1 transgenic line

Michel Cohen-Tannoudji (PI)

      The H-2Z1 transgenic line which exhibits a striking and unexpected expression profile. In this line, lacZ expression in the cerebral cortex is restricted to a subset of layer IV neurons and delineates precisely […]

Publications

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