Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
27
Aug 2015
Status
Completed
Members
1
Structures
1

About

 
 
 
The H-2Z1 transgenic line which exhibits a striking and unexpected expression profile. In this line, lacZ expression in the cerebral cortex is restricted to a subset of layer IV neurons and delineates precisely the somatosensory area.
 
 

We have used  the H-2Z1 transgene as a marker of somatosensory identity in embryonic cortex transplantation experiments in order to examine to study the role of intrinsic versus extrinsic factors in the regionalization of the neocortex. Our work has contributed to the understanding of the early events responsible for the regionalization of the forebrain, pointing to the critical role of intrinsic cues in this process.

H-2Z1 transgene expression is modified by genetic backgrounds. In a C57/CBA background, expression of the H-2Z1 transgene precisely delineates the somatosensory area and is restricted to a subset of layer IV neurons. In a BALB/c background, H-2Z1 cortical expression is wider and more intense.

H-2Z1 is an enhancer trap transgenic mouse line and as such offers also an opportunity to identify an endogenous gene with a similar expression pattern and therefore to gain further insights into early events responsible for the regionalization of the forebrain in mice as well as in other mammals. We have cloned the integration site of the H-2Z1 transgene and identified several genes in the vicinity of the integration site. All the H-2Z1 flanking genes are expressed in layer IV neurons of the somatosensory area.

The H-2Z1 is now available from the European Mouse Mutant Archive/CDTA.

 

Publications related to the H-2Z1 mouse line

Cohen-Tannoudji, M., Babinet, C., and Wassef, M. (1994). Early determination of a mouse somatosensory cortex marker. Nature 368, 460–463.

Cohen-Tannoudji, M., Morello, D. and Babinet C.(1992). Unexpected position-dependent expression of H-2 and beta 2-microglobulin/lacZ transgenes. Mol Reprod Dev 33, 149–159.

Gitton, Y., Cohen-Tannoudji, M., and Wassef, M. (1999a). Role of thalamic axons in the expression of H-2Z1, a mouse somatosensory cortex specific marker. Cereb. Cortex 9, 611–620.

Gitton, Y., Cohen-Tannoudji, M., and Wassef, M. (1999b). Specification of somatosensory area identity in cortical explants. Journal of Neuroscience 19, 4889–4898.

Mallamaci, A., Muzio, L., Chan, C.H., Parnavelas, J., and Boncinelli, E. (2000). Area identity shifts in the early cerebral cortex of Emx2-/- mutant mice. Nat Neurosci 3, 679–686.

Narboux-Nême, N., Goiame, R., Mattei, M.-G., Cohen-Tannoudji, M., and Wassef, M. (2012). Integration of H-2Z1, a Somatosensory Cortex-Expressed Transgene, Interferes with the Expression of the Satb1 and Tbc1d5 Flanking Genes and Affects the Differentiation of a Subset of Cortical Interneurons. Journal of Neuroscience 32, 7287–7300.