The immune system comprises a collection of specialized cells and organs that fight infections and can survey cancer cells. Immune responses to pathogens and tumors are highly coordinated events that take place in complex and specialized tissue microenvironments. An integrated view of innate and adaptive immune responses to infections and cancer requires a better understanding of how immune cells communicate and fulfill their task in vivo. In addition, it is essential to unravel how pathogens and tumor microenvironment subvert their functions. Recent progresses in intravital two-photon imaging offer a novel perspective to address some of these critical issues in physiological settings. By further developping functional in vivo imaging, we aim at identifying critical aspects of T cell and NK cell activation and function during tumor growth, during infection by an intracellular parasite and during transplantation. Elucidating the fundamental mechanisms underlying the regulation of innate and adaptive immune responses in vivo will delineate basic principles to develop or improve immunotherapeutical strategies to treat cancer and infectious diseases.
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About
Members
Former Members
2000
2000
Name
Position
2005
2009
Helene Beuneu
PhD Student
2007
2008
Georges Azar
Post-doc
2007
2010
Orchidee Filipe Santos
Post-doc
2008
2011
Carolyn Clark
Post-doc
2008
2011
Jacques Deguine
PhD Student
2009
2012
Kim Garrod
Post-doc
2010
2013
Andreas Muller
Post-doc
2010
2013
Helene Moreau
PhD Student
2012
2015
Romain Olekhnovitch
PhD Student
2012
2017
Beatrice Breart
Permanent Researcher
2010
2013
Andreas Müller
Post-doc
2012
2014
Pervinder Sagoo
Post-doc
2013
2013
Marcello Albanesi
Post-doc
2013
2016
Maria Almena Carrasco
Post-doc
2014
2017
David Michonneau
PhD Student
2014
2014
Milka Sarris
Post-doc
2014
2018
Idan Milo
Post-doc
2014
2019
Armelle Bohineust
Post-doc
2015
2018
Jérémy Postat
PhD Student
2016
2019
Ronan Thibaut
PhD Student
2017
2020
Marine Cazaux
PhD Student
2017
2020
Roxana Khazen
Post-doc
2021
2021
Alexander Beer
M2 Student
2018
2022
Erica Russo
Post-doc
2019
2023
Morgane Boulch
PhD Student
2019
2023
Morgane Boulch
PhD Student
2020
2023
Mathilde Ruggiu
PhD Student
Projects
Transversal Project
Software
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Publications
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2024Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes., J Exp Med 2024 Apr; 221(4): .
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2023
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2023Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity., Nat Cancer 2023 Jul; 4(7): 968-983.
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2023Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics., iScience 2023 Feb; 26(2): 106068.
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2022SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse., EMBO J 2022 Aug; (): e111528.
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2022Inflammation triggers ILC3 patrolling of the intestinal barrier., Nat Immunol 2022 Aug; (): .
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2022Spatiotemporal dynamics of calcium signals during neutrophil cluster formation., Proc Natl Acad Sci U S A 2022 Jul; 119(29): e2203855119.
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2022High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing., Nat Commun 2022 Jun; 13(1): 3111.
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2021Overexpression of IgG2 in patients resembling IgG4-related disease with normal IgG4., Scand J Immunol 2021 Dec; (): e13126.
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2021Quorum sensing governs collective dendritic cell activation in vivo., EMBO J 2021 Jun; (): e107176.
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Contact
Phone: +33 1 40 61 35 12 Email: berengere.hugot@pasteur.fr Address: Institut Pasteur, Dynamics of Immune Responses Lab, 25 Rue du Docteur Roux 75015, Paris France How to come to the lab: We are based at the INSTITUT PASTEUR in PARIS, France. The nearest underground stations are “Pasteur” (Metro 6 & 12) and “Volontaires” (Metro 12). Our lab is located on the 4th floor of the Metchnikoff building (building n°67 on the map below), room n°4012.