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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.

About

Our research focuses on cell polarization and migration in health and disease and more specifically on the regulatory mechanisms of astrocyte migration in the context of inflammation and glioblastoma invasion. Astrocytes are major glial cells of the central nervous system. They fulfil a wide variety of functions allowing neurons to develop, survive and function correctly. In a normal adult brain, astrocytes are essentially immobile and do not display any obvious polarized morphology. Under pathological situations involving inflammation of the cerebral tissue, astrocytes become reactive and polarize and migrate in a collective manner in the direction of the inflammatory site. In these conditions, cell polarization and migration are tightly regulated by the extracellular environment. Astrocytes or their precursors can give rise to very invasive tumors called gliomas. Gliomas correspond to the majority of primary brain tumors and are associated with very poor prognosis. The most aggressive gliomas, called glioblastomas, are amongst the most invasive tumors. The capacity glioblastoma cells to escape the initial tumor and migrate over long distance allow them to escape to classical therapeutic treatments.

Our aims are to identify the extracellular cues that act on astrocytes to control the speed and direction of migration, to decipher the fundamental polarity signaling which controls cell polarization during migration, and to determine how signalling cascade influence the organization of cytoskeletal elements to eventually promote cell migration.

In vitro and in vivo models are used to compare the directed collective migration of normal astrocytes to the invasion of glioblastoma cells in order to identify molecular alterations responsible for the loss of polarity and abnormal migratory behaviour of glioblastoma cells.

Members

Former Members

2023

2021

2019

2016

2015

2011

2009

2007

2000
2000
Name
Position
2015
2020
Maryse Brandt
Administrative Staff
2015
2020
Julien Elric
PhD Student
2015
2020
Flora Llense
Post-doc
2015
2020
Hélène Ribierre
Administrative Staff
2015
2020
Bertille Bance
PhD Student
2015
2020
Muguette Jehanno
Research Engineer
2015
2020
Antonio Castro-Castro
Post-doc
2015
2020
Franck Coumailleau
Permanent Researcher
2015
2020
Dora Sabino
Post-doc
2015
2020
Chiara De Pascalis
PhD Student
2015
2020
John Dallon
Visiting Scientist
2015
2020
Grégoire Mathonnet
Undergraduate Student
2015
2020
Tania Medali
Undergraduate Student
2015
2020
Guilaine Claire Nchugoua Tchiehe
Undergraduate Student
2015
2020
Anna Ritz
Undergraduate Student
2015
2020
Ben Braithwaite
Undergraduate Student
2015
2020
Astrid Boström
Graduate Student
2015
2020
Coraline Hautem
Undergraduate Student
2015
2020
Juliana Geay
Research Engineer
2015
2020
Jack Shepherd
Post-doc
2015
2020
Lavinia Capuana
PhD Student
2015
2020
Dylan Ramage
Master 2
2015
2020
Aurore Maciejewski
Master 2
2015
2020
Cécile Leduc
Permanent Researcher
2015
2020
Duc Quang Tran
Post-doc
2015
2020
Shailaja Seetharaman
PhD Student
2015
2020
Yamini Ravichandran
PhD Student
2015
2021
Kerren Murray
Research Engineer
2020
2021
Aneta Gandalovicova
Erasmus Student
2021
2021
Guillaume Rode
Master Student
2020
2021
Stéphanie Portet
Visiting Scientist
2021
2021
Baptiste d'Urso
Master Student
2021
2021
Marina Plays
Master Student
2018
2021
Emma Van BODEGRAVEN
Post-Doc
2018
2021
Gaëlle Dutour-Provenzano
PhD Student
2021
2022
Benoit Neitthoffer
Engineer Student
2022
2022
Laura Soto
Master Student
2022
2022
Julie Laplace
Master Student
2018
2023
Florent Peglion
Post-Doc
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Projects

Our research focuses on the molecular mechanisms controlling migration and invasion of normal and tumoral cells. Our projects are centered on the control of cell polarity, the impact of cell-ECM and cell-cell interaction and the role of the cytoskeleton (actin, microtubules and intermediate filaments) and cytoskeletal crosstalk in cell mechanics and mechanotransduction during cell invasion through complex, mechanically challenging environment. We essentially work with normal glial cells and glioblastoma cells in in vitro and in vivo models.

Glioblastoma multiforme (GBM), also known as astrocytoma grade IV, is the most common type of primary brain tumors with a very poor prognosis for patients. The invasive character of GBM is one of the main contributors to the poor prognosis as cells migrate away from the tumor core, evade therapy and initiate recurrence. Tumor invasion is also what ultimately causes the death of patients by altering essential brain tissues. Current diagnostic methods cannot identify the invasive cells and do not accurately predict tumor spreading. Hence, there is an urgent need for a molecular signature of GBM cell invasive properties. This requires fundamental knowledge on the biology of GBM and their mechanisms of invasion through the healthy brain parenchyma. One general goal of the lab projects is to identify molecular alterations characteristic of invading GBM cells.

Transversal Project

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Publications

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CNRS UMR3691

Contact

Address : 25-28 Rue du Docteur Roux 75015, Paris France