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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.

About

Our research focuses on cell polarization and migration in heath and disease and more specifically on the regulatory mechanisms of astrocyte migration in the context of inflammation and glioblastoma invasion. Astrocytes are major glial cells of the central nervous system. They fulfil a wide variety of functions allowing neurons to develop, survive and function correctly. In a normal adult brain, astrocytes are essentially immobile and do not display any obvious polarized morphology. Under pathological situations involving inflammation of the cerebral tissue, astrocytes become reactive and polarize and migrate in a collective manner in the direction of the inflammatory site. In these conditions, cell polarization and migration are tightly regulated by the extracellular environment. Astrocytes or their precursors can give rise to very invasive tumors called gliomas. Gliomas correspond to the majority of primary brain tumors and are associated with very poor prognosis. The most aggressive gliomas, called glioblastomas, are amongst the most invasive tumors. The capacity glioblastoma cells to escape the initial tumor and migrate over long distance allow them to escape to classical therapeutic treatments.

Our aims are to identify the extracellular cues that act on astrocytes to control the speed and direction of migration, to decipher the fundamental polarity signaling which controls cell polarization during migration, and to determine how signalling cascade influence the organization of cytoskeletal elements to eventually promote cell migration.

In vitro and in vivo models are used to compare the directed collective migration of normal astrocytes to the invasion of glioblastoma cells in order to identify molecular alterations responsible for the loss of polarity and abnormal migratory behaviour of glioblastoma cells.

 

Projects

Transversal Project

Fundings

Publications

Download

CNRS UMR3691

Lab's Events

  • Sandrine ETIENNE-MANNEVILLE : Conférence ECF-FEBS, September 20-24, 2018, Prague
  • Cécile LEDUC : Invited speaker to Physics of Cancer, September 24-26, 2018, Leipzig (Germany)
  • Cécile LEDUC : GDR CellTiss, October 1-3,2018, La Chapelle-Gauthier (France)
  • Sandrine ETIENNE-MANNEVILLE : MBI Meeting, November 4-11, 2018, Singapore
  • Sandrine ETIENNE-MANNEVILLE : Scientific collaboration with the University of Pennsylvania, November 11-14,2018, Philadelphia

Pictures & Media

Cell polarity, migration and Cancer Unit, Institut Pasteur, October 2018

Contact

Address : 25-28 Rue du Docteur Roux 75015, Paris France