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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
05
Aug 2021
Status
Ongoing
Members
2
Structures
2

About

Role of the E-protein in intracellular viral behavior  (Batiste Boëda, INSERM)

The coronavius genome encodes four major structural proteins: the spike (S) protein, nucleocapsid (N) protein, membrane (M) protein, and the envelope (E) protein. Interestingly (E) has been recently shown to interact with human proteins expressed in infected human epithelium and playing a role in apico-basal cell polarity. We are engaged in the molecular characterization of these interactions in order to understand how and why the coronavirus manipulates cellular polarity pathways.