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The project at a glance: An unexpected finding was the discovery that muscle stem cells in different anatomical locations are programmed with distinct upstream regulators prior to acquiring myogenic identity. This intriguing observation is […]

BAXERNA (www.baxerna.eu) is an EU-funded project that will develop next-generation mRNA vaccines against devastating bacterial infections like tuberculosis. The project consortium is led by researchers from VIB and UGent and includes multiple prominent European […]

Mycobacterium ulcerans causes Buruli ulcer, a neglected tropical skin disease manifesting as chronic wounds that can leave victims with major, life-long deformity and disability. Differently from other mycobacteria, including the related M. tuberculosis and […]

Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]

IMMUNSCAN-PILOTE est une recherche scientifique menée grâce à l’utilisation de données et d’échantillons biologiques collectées dans le cadre de la cohorte COSIPOP Quel est l’objectif d’IMMUNSCAN-PILOTE ? L’objectif est de mettre au point, à […]

Lipid droplets as innate immunity hubs Successful defence against invaders is critical for survival of eukaryotic cells. Microbes have developed many strategies to subvert host organisms which, in turn, evolved several innate immune responses […]

pour piéger des micro-organismes pathogènes. Quel est l’objectif de cette demande ? L’objectif est d’identifier l’origine de l’ADN libéré, celui-ci pouvant provenir du noyau des cellules ou des mitochondries cellulaires ou des micro-organismes. Quelles […]

Alterations of the gut microbiota are associated with numerous diseases, of which many involve impaired immune tolerance, such as allergies. However, the role of specific microorganisms and underlying molecular mechanisms remain poorly characterised. Archaeal […]

Sorry, this entry is only available in FR.

Sorry, this entry is only available in FR.

The intestine and skin constitute surface barriers between the host and the environment, which contains an abundant microbiota, antigens and potential pathogens. As barrier sites are constantly exposed to microbial and damaging elements that […]

Cancer is increasingly recognized as a multifactorial disease, resulting from a dysregulated communication between different cell types of the tumor microenvironment, including cancer cells, innate and adaptive immune cells, as well as heterogeneous populations […]

 The Nano Flow Cytometry Pipeline at the Cytometry Platfrom, CBUTechS Cytometry POSTER – Nano flow cytometry pipeline In order to bring more insight into the mechanisms of transfer of biological molecules such as proteins […]

Multiple Myeloma (MM) is an incurable malignancy characterized by the uncontrolled expansion of plasma cells in the bone marrow. While proteasome inhibitors like bortezomib efficiently halt MM progression drug resistance inevitably develop, and novel […]

Sorry, this entry is only available in FR.

Sorry, this entry is only available in FR.

Research in the Innate Immunity Unit strives to understand the signals that regulate lymphoid lineage development and the mechanisms that promote the functional diversification of lymphocyte responses. Modeling Hepatitis B virus infections in a […]

Chikungunya is a mosquito-transmitted disease of sub-tropical areas caused by an alphavirus, the Chikungunya virus (CHIKV). CHIKV infection has re-emerged after several decades causing large outbreaks, making it an important public health concern. The […]

 Antibody-based anti-tumor immunotherapy that aims at identifying the human FcγRs involved in melanoma and/or breast cancer immunotherapy, and at identifying the effector population(s) responsible for tumor destruction

Broadly neutralizing HIV-1 antibodies (bNAbs) can develop in rare infected individuals several years after co-evolution with diversifying viruses. In animal models, passive immunotherapy with potent HIV-1 bNAbs has been shown to protect from infection […]

In the human colon, mucus protects the underlying epithelium from pathogens. During infection, pathogens and resident microbiota compete for nutritional metabolites and therefore changes may alter the equilibrium in the colon ecosystem contributing to […]

Clinical and pathological consequences of human anti-drug antibodies (NASA study) that aims at demonstrating in the clinic that neutrophils are activated by antibody-curare complexes and involved in curare-induced anaphylaxis (allergic shock) in humans, and […]

Hepatitis C virus (HCV) infection can trigger the development of autoimmune disorders among which, cryobulininemic vasculatitis is the most prevalent. HCV-associated cryobulininemic vasculatitis is mediated by mono-/oligo-clonal IgM cryoglobulins with rheumatoid factor activity, thought […]

Rationnel La polypose adénomateuse familiale se manifeste par l’apparition dans l’intestin de nombreuses excroissances dénommées polypes adénomateux et susceptibles d‘évoluer en cancers en l’absence de prise en charge. Il s’agit d’une maladie génétique, le […]

 Cryptococcus neoformans is a sugar-coated yeast that is able to interact closely with numerous organisms in the environment including amebae, paramecium of nematodes. The interaction with these organisms probably shaped its virulence. The ability […]

Cytokines are soluble molecules that regulate a large array of developmental processes. In the hematopoietic system, cytokines mediate the production of mature blood cells from specific lineages, by directly acting on hematopoietic progenitors. Cytokines […]

Developing novel models of disease and vaccination in Ab- and FcR-humanized mice: establishment in these mice of clinically pertinent models of allergic and autoimmune (inflammatory) diseases. Refer to European Research Council Grant “MyeloSHOCK for […]

 In this project we propose to combine ultrahigh-throughput screening of primary B cells using droplet based microfluidics with next-generation sequencing to profile entire B cell antibody repertoires. This process will enable highly-efficient and rapid […]

Scientific Background Differentiation of naïve CD4+ T lymphocytes into functionally distinct T helper cell subsets is essential for efficient immune responses against different types of pathogens. Effector T cell lineages selectively produce specific sets […]

To fight cancer or infections, a variety of immune cells are engaged in a tremendously complex, yet highly coordinated sequence of cellular processes. This coordination is enforced by distinct mechanisms of cellular communication allowing […]

The immune system is made up of specialized cells and tissues that act together to fight microbial infections and survey the body for malignant transformation. Immune responses are highly orchestrated and dynamic events that […]

Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers

Anaphylaxis is a hyperacute allergic reaction of increasing incidence that can be of fatal consequence and that has no specific treatment. Anaphylaxis is thought to rely on mechanisms involving mast cells that bear allergen-specific […]

Human Antibody Responses to Viruses Adaptive immune responses naturally occurring upon infection or induced by vaccination generate high affinity antibodies, and memory B-cell subsets to respond to further antigenic challenges, providing protection against (re-)infections. […]

Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]

The survival of organisms requires the ability to repair tissues upon injury, as well as, after birth, to fight foreign invaders that may have contaminated the wound. This last function is mediated by a […]

In this project, we build on our previous work of T lymphocyte homeostasis after allogeneic hematopoietic stem cell transplantation (HSCT). We explore early lymphocyte reconstitution and immunological mechanisms of GVHD versus functional immune tolerance. […]

  B and T cell lymphoid cancers are among the most common human malignancies. Many factors, endogenous and exogenous, are implicated in the etiology of these disorders, but key oncogenic lesions often arise through […]

A fundamental concept on the development of the natural regulatory cells is that the thymus only exports regulatory T cells after the third day post-birth, implying a differential developmental program controlling the generation of […]

The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes  bimonthly meetings and seminars around an HIV / AIDS research topic. Since 2021, the meetings may also include topics related to emerging viruses. […]

We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]

Human infections caused by hepatitis B virus (HBV) are major healthcare issues. Despite available effective vaccines, more than 250 million individuals worldwide are chronically infected by HBV, which accounts for approximately 1 million deaths […]

The objective of this research project is to understand the molecular and functional basis of the memory B-cell antibody response to the SARS-CoV-2 Spike protein. One of the key goals of this research program […]

Rare infected individuals who initiated antiretroviral therapy (ART) very early during primary infection can enter in remission after its interruption, a phenomenon known as post-treatment control. Interestingly, early treatment has been associated with the […]

Immune cells modulate CNS activities in physiology, but peripheral immune cells are rarely found in direct contact with the neural tissue. Instead, the immune cells are thought to affect the brain remotely and indirectly, […]

Cytotoxic T cells and NK cells (CTLs) are key players of anti-tumor immune responses. Despite our fundamental knowledge on the interplay between the immune system and tumor microenvironments, we have a poor understanding on […]

Intracellular pathogens have developed strategies to survive in infected cells and reduce their recognition by the innate and adaptive immune systems. Our lab wishes to define the mechanisms influencing the recognition of infected cells […]

Transplant rejection involves a coordinated attack of donor cells by the innate and the adaptive immune system of the host. To gain insight into this dynamic process, we have developed an ear skin graft […]

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We found that RoRgt expressing innate lymphoid cells (ILC) develop in the fetal liver but not in the bone marrow (BM). However, BM progenitors give rise to RoRgt+ILC in the peripheral lymphoid organs and […]

Mucosal transmission of HIV-1 can induce a local production of IgG and IgA antibodies predominantly targeting the gp41 subunit of the viral envelope glycoprotein gp160. However, whether they limit viral dissemination upon HIV-1 exposure […]

The past years have been marked by a leap forward in our understanding of the genetic basis of many diseases. In particular, genome-wide association studies (GWAS) have provided insight into the “genetic architecture” of […]

Adaptive immune responses are initiated in secondary lymphoid organs through cellular interactions between antigen-specific T cells and antigen-presenting dendritic cells. One of the aim of our lab is to better understand how T cells […]

Chromosomal translocations can promote cancer development by disrupting tumor suppressors, activating oncogenes, or generating aberrant fusion proteins. Fusion genes are frequent in cancers and are used as diagnostic and prognostic tools to classify and […]

  DNA double-strand breaks (DSBs), although common, are extremely dangerous (Deriano and Roth, Annual Review of Genetics, 2013). Unlike most other DNA lesions, DSBs directly threaten genomic integrity by disrupting the physical continuity of […]

Microglia are extremely specialized immune cells, which reside in the CNS and play key roles in its development, homeostasis and disease. Such specialization is imposed by the peculiar environment the microglia have to live […]

Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]

The perspective to harness the potent immunosuppressive activity of CD4+FOXP3+ regulatory T cells (Treg) for clinical applications has sparked enormous interest in this cell population. Recent studies, however, have shown that the human Treg […]

Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]

La polypose adénomateuse familiale est une maladie caractérisée par l’apparition dans l’intestin de nombreux polypes susceptibles d‘évoluer en cancer en l’absence de prise en charge. Il s’agit d’une maladie génétique rare, le plus souvent […]

Role of platelets and their interactions in allergic diseases that aims at understanding how platelets induce/promote/regulate antibody-induced allergic diseases, their interaction partners (myeloid cells, endothelium) and their dynamics.

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Cancer cells frequently harbor somatic mutations leading to altered DNA repair pathways. In some cases, these defects can be therapeutically exploited as these tumor cells, but not healthy cells, rely on compensatory DNA repair […]

The symbiotic microbiota plays an essential role at many levels of host physiology, and germfree mice develop a large number of defects. In the intestine, the microbiota metabolises nutrients and toxins to generate an […]

We recently found (Ramond et al 2014, Nat Immunol) that the mouse thymus is colonized by successive waves of progenitors that differ in their developmental stage and function. Our observations show that the T […]

Interaction with heparan sulfate proteoglycans is supposed to provide chemokines with the capacity to immobilize on cell surface and extracellular matrix for accomplishing both tissue homing and signaling of attracted cells. The laboratory of […]

Innate lymphoid cells (ILCs) are a newly discovered family of lymphocytes that is mobilizing the immunological community worldwide. Three types of ILCs have been described, termed ILC1, 2 and 3, which phenocopy T helper […]

“The thymus is a specialized organ that provides a unique environment for T cell development and differentiation. The study the thymus-settling progenitors (TSPs) and how they differentiate is important for the characterization of the […]

The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]

The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]

Dengue is caused by dengue virus (DENV), a virus which can be transmitted by Aedes mosquitos. Half of the world’s population live in areas where the mosquito and the virus are circulating. Infection by […]

We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]