Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Lucie Peduto, Institut Pasteur
Stroma du ganglion lymphatique
Starting Date
01
Feb 2016
Ending Date
01
Sep 2018
Status
Ongoing
Members
4
Structures
1

About

The immune system is composed of lymphoid and myeloid cells of hematopoietic origin that patrol the body for infection or injury. These immune mobile cells rely on signals produced by non-hematopoietic sessile cells, such as endothelial cells and a variety of ill-defined stromal cells including fibroblasts, perivascular cells and pericytes, to gain access to lymphoid tissues or injured/infected sites, and to form inflammatory aggregates. A distinct subset of stromal cells, called Lymphoid stromal (LS) cells, express structural chemokines, adhesion molecules and cytokines that are required to stabilize lymphoid tissues and play a central organizing role in the guidance and survival of leukocytes in lymphoid tissues. We have shown that LS cells are programmed during the fetal development of lymphoid tissues as well as in lymphocyte-rich organs such as the gut, and are re-induced by injury to organize lymphocyte recruitment in inflammatory lesions and tumors. They express the marker gp38 (podoplanin) and produce critical signals for leucocyte recruitment, survival and lymphangiogenesis. In the intestine, we have shown that CD34+ Gp38+ LS cells are an essential component of the intestinal epithelial stem cells (IESCs) niche at homeostasis, and contribute to intestinal inflammation after injury.
 
Stzepourginski et al., PNAS 2017
 
We are currently studying the cellular and molecular mechanisms that induce LS cells activation and expansion during inflammation and infection, as well as their crosstalk with immune cells, endothelial cells and parenchymal cells.