Structure Content

Certaines cellules du système immunitaire périphérique, présentes dans la moelle osseuse, le sang et les ganglions lymphatiques, ont récemment été décrites comme influençant l’évolution de la maladie d’Alzheimer (MA), une terrible maladie neurodégénérative associée […]

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Le plexus choroïde (PC) est une barrière entre le sang et le cerveau qui produit le liquide cérébrospinal (LCS), le liquide dans lequel le cerveau flotte (oui ! Votre cerveau flotte en suspension dans […]

Mycobacterium ulcerans causes Buruli ulcer, a neglected tropical skin disease manifesting as chronic wounds that can leave victims with major, life-long deformity and disability. Differently from other mycobacteria, including the related M. tuberculosis and […]

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Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]

IMMUNSCAN-PILOTE est une recherche scientifique menée grâce à l’utilisation de données et d’échantillons biologiques collectées dans le cadre de la cohorte COSIPOP. Quel est l’objectif d’IMMUNSCAN-PILOTE ? L’objectif est de mettre au point, à […]

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NETOSIS est une demande d’utilisation à des fins scientifiques de données et d’échantillons de participants de la cohorte COSIPOP. Quel est l’objectif ? L’objectif est de décrire un processus se produisant en cas d’infection […]

Rare infected individuals who initiated antiretroviral therapy (ART) very early during primary infection can enter in remission after its interruption, a phenomenon known as post-treatment control. Interestingly, early treatment has been associated with the […]

PHAGESAFETY est une recherche scientifique impliquant l’utilisation de données et d’échantillons collectés dans le cadre de la cohorte COSIPOP. Quel est l’objectif de PHAGESAFETY ? L’objectif est d’identifier des marqueurs sanguins permettant d’évaluer la […]

Dès la naissance, le cerveau et le système immunitaire sont soumis à de nouveaux stimuli environnementaux auxquels ils doivent s’adapter rapidement. Tandis que le cerveau s’habitue à diverses stimulations visuelles, saveurs et textures, le […]

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Contexte de l’étude PoxVac22 La variole du singe est une maladie infectieuse apparentée à la variole (éradiquée en 1980), causée par un virus. Ce virus a été décrit pour la première fois chez l’homme […]

Présentation La maladie de Verneuil, est une maladie inflammatoire chronique de la peau très douloureuse et invalidante. A ce jour il n’existe aucun traitement permettant de la guérir. Les causes de la maladie sont […]

La dernière actualisation de cette page a été faite le 14/05/2025 Cette page est destinée aux participants de l’étude Pso23 ainsi qu’à toutes les personnes intéressées et/ou concernées par cette étude. Elle regroupe : […]

The intestine contains abundant and heterogeneous populations of stromal cells. Using several genetic approaches as well as intestinal organoid models, we are investigating the role of the stromal microenvironment in intestinal homeostasis and repair,  […]

Tumor progression, invasion and ultimately metastasis result from interactions between cancer cells and their supporting stromal microenvironment. The tumor stromal microenvironment share many similarities with fibrotic stroma and comprises extracellular matrix components, as well […]

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The survival of organisms requires the ability to repair tissues upon injury, as well as, after birth, to fight foreign invaders that may have contaminated the wound. This last function is mediated by a […]

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URIBOC est une recherche scientifique menée grâce à l’utilisation de données et d’échantillons biologiques collectées dans le cadre de la cohorte COSIPOP. Quel est l’objectif d’URIBOC ? L’objectif est de réaliser des tests sur […]

TPAI est une demande d’utilisation de données et d’échantillons biologiques collectés dans le cadre de la cohorte COSIPOP. Quel est l’objectif de TPAI ?  L’objectif est de permettre à des étudiants d’apprendre à utiliser […]

Vous participez à l’étude Ton23, cette page vous est destinée. Vous y trouverez : Étude Ton23 Les amygdales sont des organes qui participent à la défense de l’organisme en produisant des cellules immunitaires, favorisant […]

TTP est une demande d’utilisation d’échantillons collectés dans le cadre du projet de recherche COSIPOP. Quel est l’objectif ? L’objectif de la demande est le développement et la validation de technologies de pointe d’analyse […]

NEUTROBLOOD est une demande d’utilisation de données et d’échantillons biologiques collectés dans le cadre de la cohorte COSIPOP. Quel est l’objectif de NEUTROBLOOD ?  L’objectif est de mettre au point une méthode d’isolement d’un […]

DENDRINTER est une demande d’utilisation à des fins scientifiques d’échantillons et de données collectés auprès des participants COSIPOP (Institut Pasteur). Quel est l’objectif ? L’objectif est de caractériser des molécules ou des cellules circulant dans […]

Vous participez à l’étude SHINE-HS, cette page vous est destinée. Vous y trouverez : Date de dernière actualisation : 20/08/2025 Contextualisation et objectif de l’étude Les femmes et les hommes présentent de nombreuses différences, notamment […]

PERTSEVERE II- SIMOA SETUP est une demande d’utilisation à des fins scientifiques de données et d’échantillons de participants de la cohorte COSIPOP. Quel est l’objectif ? L’objectif de la demande de développer une technique […]

Research in the Innate Immunity Unit strives to understand the signals that regulate lymphoid lineage development and the mechanisms that promote the functional diversification of lymphocyte responses. Modeling Hepatitis B virus infections in a […]

Chikungunya is a mosquito-transmitted disease of sub-tropical areas caused by an alphavirus, the Chikungunya virus (CHIKV). CHIKV infection has re-emerged after several decades causing large outbreaks, making it an important public health concern. The […]

Broadly neutralizing HIV-1 antibodies (bNAbs) can develop in rare infected individuals several years after co-evolution with diversifying viruses. In animal models, passive immunotherapy with potent HIV-1 bNAbs has been shown to protect from infection […]

In the human colon, mucus protects the underlying epithelium from pathogens. During infection, pathogens and resident microbiota compete for nutritional metabolites and therefore changes may alter the equilibrium in the colon ecosystem contributing to […]

Hepatitis C virus (HCV) infection can trigger the development of autoimmune disorders among which, cryobulininemic vasculatitis is the most prevalent. HCV-associated cryobulininemic vasculatitis is mediated by mono-/oligo-clonal IgM cryoglobulins with rheumatoid factor activity, thought […]

Rationnel La polypose adénomateuse familiale se manifeste par l’apparition dans l’intestin de nombreuses excroissances dénommées polypes adénomateux et susceptibles d‘évoluer en cancers en l’absence de prise en charge. Il s’agit d’une maladie génétique, le […]

 Cryptococcus neoformans is a sugar-coated yeast that is able to interact closely with numerous organisms in the environment including amebae, paramecium of nematodes. The interaction with these organisms probably shaped its virulence. The ability […]

Cytokines are soluble molecules that regulate a large array of developmental processes. In the hematopoietic system, cytokines mediate the production of mature blood cells from specific lineages, by directly acting on hematopoietic progenitors. Cytokines […]

Scientific Background Differentiation of naïve CD4+ T lymphocytes into functionally distinct T helper cell subsets is essential for efficient immune responses against different types of pathogens. Effector T cell lineages selectively produce specific sets […]

To fight cancer or infections, a variety of immune cells are engaged in a tremendously complex, yet highly coordinated sequence of cellular processes. This coordination is enforced by distinct mechanisms of cellular communication allowing […]

The immune system is made up of specialized cells and tissues that act together to fight microbial infections and survey the body for malignant transformation. Immune responses are highly orchestrated and dynamic events that […]

Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers

Human Antibody Responses to Viruses Adaptive immune responses naturally occurring upon infection or induced by vaccination generate high affinity antibodies, and memory B-cell subsets to respond to further antigenic challenges, providing protection against (re-)infections. […]

Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]

In this project, we build on our previous work of T lymphocyte homeostasis after allogeneic hematopoietic stem cell transplantation (HSCT). We explore early lymphocyte reconstitution and immunological mechanisms of GVHD versus functional immune tolerance. […]

  B and T cell lymphoid cancers are among the most common human malignancies. Many factors, endogenous and exogenous, are implicated in the etiology of these disorders, but key oncogenic lesions often arise through […]

A fundamental concept on the development of the natural regulatory cells is that the thymus only exports regulatory T cells after the third day post-birth, implying a differential developmental program controlling the generation of […]

The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes  bimonthly meetings and seminars around an HIV / AIDS research topic. Meetings and seminars are open to all. Meetings are usually held on […]

We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]

Human infections caused by hepatitis B virus (HBV) are major healthcare issues. Despite available effective vaccines, more than 250 million individuals worldwide are chronically infected by HBV, which accounts for approximately 1 million deaths […]

The objective of this research project is to understand the molecular and functional basis of the memory B-cell antibody response to the SARS-CoV-2 Spike protein. One of the key goals of this research program […]

Cytotoxic T cells and NK cells (CTLs) are key players of anti-tumor immune responses. Despite our fundamental knowledge on the interplay between the immune system and tumor microenvironments, we have a poor understanding on […]

Intracellular pathogens have developed strategies to survive in infected cells and reduce their recognition by the innate and adaptive immune systems. Our lab wishes to define the mechanisms influencing the recognition of infected cells […]

Transplant rejection involves a coordinated attack of donor cells by the innate and the adaptive immune system of the host. To gain insight into this dynamic process, we have developed an ear skin graft […]

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We found that RoRgt expressing innate lymphoid cells (ILC) develop in the fetal liver but not in the bone marrow (BM). However, BM progenitors give rise to RoRgt+ILC in the peripheral lymphoid organs and […]

Mucosal transmission of HIV-1 can induce a local production of IgG and IgA antibodies predominantly targeting the gp41 subunit of the viral envelope glycoprotein gp160. However, whether they limit viral dissemination upon HIV-1 exposure […]

The past years have been marked by a leap forward in our understanding of the genetic basis of many diseases. In particular, genome-wide association studies (GWAS) have provided insight into the “genetic architecture” of […]

Adaptive immune responses are initiated in secondary lymphoid organs through cellular interactions between antigen-specific T cells and antigen-presenting dendritic cells. One of the aim of our lab is to better understand how T cells […]

Chromosomal translocations can promote cancer development by disrupting tumor suppressors, activating oncogenes, or generating aberrant fusion proteins. Fusion genes are frequent in cancers and are used as diagnostic and prognostic tools to classify and […]

  DNA double-strand breaks (DSBs), although common, are extremely dangerous (Deriano and Roth, Annual Review of Genetics, 2013). Unlike most other DNA lesions, DSBs directly threaten genomic integrity by disrupting the physical continuity of […]

Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]

The perspective to harness the potent immunosuppressive activity of CD4+FOXP3+ regulatory T cells (Treg) for clinical applications has sparked enormous interest in this cell population. Recent studies, however, have shown that the human Treg […]

Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]

La polypose adénomateuse familiale est une maladie caractérisée par l’apparition dans l’intestin de nombreux polypes susceptibles d‘évoluer en cancer en l’absence de prise en charge. Il s’agit d’une maladie génétique rare, le plus souvent […]

La dernière actualisation de cette page a été faite le 20/01/2025 Cette page est destinée aux participants de l’étude SpA23 ainsi qu’à toutes les personnes intéressées et/ou concernées par cette étude. Elle regroupe : […]

Cancer cells frequently harbor somatic mutations leading to altered DNA repair pathways. In some cases, these defects can be therapeutically exploited as these tumor cells, but not healthy cells, rely on compensatory DNA repair […]

The symbiotic microbiota plays an essential role at many levels of host physiology, and germfree mice develop a large number of defects. In the intestine, the microbiota metabolises nutrients and toxins to generate an […]

We recently found (Ramond et al 2014, Nat Immunol) that the mouse thymus is colonized by successive waves of progenitors that differ in their developmental stage and function. Our observations show that the T […]

Interaction with heparan sulfate proteoglycans is supposed to provide chemokines with the capacity to immobilize on cell surface and extracellular matrix for accomplishing both tissue homing and signaling of attracted cells. The laboratory of […]

Innate lymphoid cells (ILCs) are a newly discovered family of lymphocytes that is mobilizing the immunological community worldwide. Three types of ILCs have been described, termed ILC1, 2 and 3, which phenocopy T helper […]

“The thymus is a specialized organ that provides a unique environment for T cell development and differentiation. The study the thymus-settling progenitors (TSPs) and how they differentiate is important for the characterization of the […]

The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]

The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]

Dengue is caused by dengue virus (DENV), a virus which can be transmitted by Aedes mosquitos. Half of the world’s population live in areas where the mosquito and the virus are circulating. Infection by […]

We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]