Chikungunya is a mosquito-transmitted disease of sub-tropical areas caused by an alphavirus, the Chikungunya virus (CHIKV). CHIKV infection has re-emerged after several decades causing large outbreaks, making it an important public health concern. The role of antibodies in controlling CHIKV infection has been documented but the memory B-cell immunity to CHIKV remains poorly understood. To investigate the human memory antibody response to CHIKV, we cloned 108 anti-E1E2 CHIKV human monoclonal antibodies from IgG+ memory B cells of individuals who recovered from the 2006 CHIKV outbreak in La Réunion island. These antibodies are currently being characterized in details at a molecular and functional level.