• 2024
  Minh-son Phan, Jang-Mi Kim, Cara Picciotto, Lydie Couturier, Nisha Veits, Khallil Mazouni, François Schweisguth, Symmetry breaking and fate divergence during lateral inhibition in Drosophila, Development .
• 2024
  Lydie Couturier, Juan Luna-Escalante, Khallil Mazouni, Claire Mestdagh, Minh-Son Phan, Jean-Yves Tinevez, François Schweisguth, Francis Corson, Pulsatile dynamics propagate crystalline order in the developing Drosophila eye, Published in BioRxiv a preprint server for Biology https://www.biorxiv.org/content/10.1101/2024.07.11.603179v1 - July 16 2024.
• 2022
  Lydie Couturier, Juan Luna, Khalil Mazouni, Claire Mestdagh, Minh-Son Phan, Francis Corson, Francois Schweisguth, HaloTag-based reporters for sparse labeling and cell tracking, Fly, 2022, 16 (1), pp.360-366. ⟨10.1080/19336934.2022.2142460⟩.
• 2021
  Blackie L, Tozluoglu M, Trylinski M, Walther RF, Schweisguth F, Mao Y, Pichaud F, , A combination of Notch signaling, preferential adhesion and endocytosis induces a slow mode of cell intercalation in the Drosophila retina., Development 2021 05; 148(10): .
• 2020
  Shard C, Luna-Escalante J, Schweisguth F, , Tissue-wide coordination of epithelium-to-neural stem cell transition in the Drosophila optic lobe requires Neuralized., J Cell Biol 2020 11; 219(11): .
• 2019
  Couturier L, Mazouni K, Corson F, Schweisguth F, Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila., Nat Commun 2019 Aug; 10(1): 3486.
• 2019
  Viswanathan R, Necakov A, Trylinski M, Harish RK, Krueger D, Esposito E, Schweisguth F, Neveu P, De Renzis S, Optogenetic inhibition of Delta reveals digital Notch signalling output during tissue differentiation, EMBO Rep. 2019 Oct;:e47999.
• 2019
  Trylinski M, Schweisguth F, Activation of Arp2/3 by WASp Is Essential for the Endocytosis of Delta Only during Cytokinesis in Drosophila, Cell Rep 2019 Jul;28(1):1-10.e3.
• 2019
  Schweisguth F, Corson F, Self-Organization in Pattern Formation, Dev. Cell 2019 Jun;49(5):659-677.
• 2019
  Gervais L, van den Beek M, Josserand M, Sallé J, Stefanutti M, Perdigoto CN, Skorski P, Mazouni K, Marshall OJ, Brand AH, Schweisguth F, Bardin AJ, Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4, Dev. Cell 2019 May;49(4):556-573.e6.
• 2019
  Henrique D, Schweisguth F, Mechanisms of Notch signaling: a simple logic deployed in time and space, Development 2019 Feb;146(3).
• 2018
  Andriatsilavo M, Stefanutti M, Siudeja K, Perdigoto CN, Boumard B, Gervais L, Gillet-Markowska A, Al Zouabi L, Schweisguth F, Bardin AJ, Spen limits intestinal stem cell self-renewal, PLoS Genet. 2018 11;14(11):e1007773.
• 2017
  Couturier L, Mazouni K, Bernard F, Besson C, Reynaud E, Schweisguth F, Regulation of cortical stability by RhoGEF3 in mitotic Sensory Organ Precursor cells in Drosophila., Biol Open 2017 Dec; 6(12): 1851-1860.
• 2017
  Perez-Mockus G, Mazouni K, Roca V, Corradi G, Conte V, Schweisguth F, Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila, Nat Commun 2017 Nov;8(1):1594.
• 2017
  Perez-Mockus G, Schweisguth F, Cell Polarity and Notch Signaling: Linked by the E3 Ubiquitin Ligase Neuralized?, Bioessays 2017 Nov;39(11).
• 2017
  Trylinski M, Mazouni K, Schweisguth F, Intra-lineage Fate Decisions Involve Activation of Notch Receptors Basal to the Midbody in Drosophila Sensory Organ Precursor Cells, Curr. Biol. 2017 Aug;27(15):2239-2247.e3.
• 2017
  Perez-Mockus G, Roca V, Mazouni K, Schweisguth F, Neuralized regulates Crumbs endocytosis and epithelium morphogenesis via specific Stardust isoforms, J. Cell Biol. 2017 May;216(5):1405-1420.
• 2017
  Pontier SM, Schweisguth F, Response to “Does pupal communication influence Wolbachia-mediated cytoplasmic incompatibility?”, Curr. Biol. 2017 Jan;27(2):R55-R56.
• 2016
  Bivik C, MacDonald RB, Gunnar E, Mazouni K, Schweisguth F, Thor S, Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling, PLoS Genet. 2016 Apr;12(4):e1005984.
• 2015
  Pontier SM, Schweisguth F, A Wolbachia-Sensitive Communication between Male and Female Pupae Controls Gamete Compatibility in Drosophila, Curr. Biol. 2015 Sep;25(18):2339-48.
• 2015
  Besson C, Bernard F, Corson F, Rouault H, Reynaud E, Keder A, Mazouni K, Schweisguth F, Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells, Curr. Biol. 2015 Apr;25(8):1104-10.
• 2015
  Schweisguth F, Asymmetric cell division in the Drosophila bristle lineage: from the polarization of sensory organ precursor cells to Notch-mediated binary fate decision, Wiley Interdiscip Rev Dev Biol 2015 May-Jun;4(3):299-309.
• 2014
  Couturier L, Trylinski M, Mazouni K, Darnet L, Schweisguth F, A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo., J Cell Biol 2014 Nov; 207(3): 351-63.
• 2014
  Coumailleau F, Schweisguth F, Insensible is a novel nuclear inhibitor of Notch activity in Drosophila, PLoS ONE 2014;9(6):e98213.
• 2014
  Rouault H, Santolini M, Schweisguth F, Hakim V, Imogene: identification of motifs and cis-regulatory modules underlying gene co-regulation, Nucleic Acids Res. 2014 Jun;42(10):6128-45.
• 2014
  Couturier L, Schweisguth F, Antibody uptake assay and in vivo imaging to study intracellular trafficking of Notch and Delta in Drosophila., Methods Mol Biol 2014 ; 1187(): 79-86.
• 2013
  Mathieu J, Cauvin C, Moch C, Radford SJ, Sampaio P, Perdigoto CN, Schweisguth F, Bardin AJ, Sunkel CE, McKim K, Echard A, Huynh JR, Aurora B and cyclin B have opposite effects on the timing of cytokinesis abscission in Drosophila germ cells and in vertebrate somatic cells, Dev. Cell 2013 Aug;26(3):250-65.
• 2013
  Couturier L, Mazouni K, Schweisguth F, Inhibition of Notch recycling by Numb: relevance and mechanism(s)., Cell Cycle 2013 Jun; 12(11): 1647-8.
• 2013
  Couturier L, Mazouni K, Schweisguth F, Numb localizes at endosomes and controls the endosomal sorting of notch after asymmetric division in Drosophila., Curr Biol 2013 Apr; 23(7): 588-93.
• 2012
  Dornier E, Coumailleau F, Ottavi JF, Moretti J, Boucheix C, Mauduit P, Schweisguth F, Rubinstein E, TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals, J. Cell Biol. 2012 Oct;199(3):481-96.
• 2012
  Liu S, Bonner JM, Chanet S, Commisso C, Skwarek LC, Schweisguth F, Boulianne GL, Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling, Mol. Cell. Biol. 2012 Dec;32(24):4933-45.
• 2012
  Chanet S, Schweisguth F, Regulation of epithelial polarity by the E3 ubiquitin ligase Neuralized and the Bearded inhibitors in Drosophila, Nat. Cell Biol. 2012 May;14(5):467-76.
• 2012
  Couturier L, Vodovar N, Schweisguth F, Endocytosis by Numb breaks Notch symmetry at cytokinesis., Nat Cell Biol 2012 Jan; 14(2): 131-9.
• 2011
  Pontier SM, Schweisguth F, Glycosphingolipids in signaling and development: from liposomes to model organisms, Dev. Dyn. 2012 Jan;241(1):92-106.
• 2011
  Perdigoto CN, Schweisguth F, Bardin AJ, Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine, Development 2011 Nov;138(21):4585-95.
• 2011
  del Álamo D, Rouault H, Schweisguth F, Mechanism and significance of cis-inhibition in Notch signalling, Curr. Biol. 2011 Jan;21(1):R40-7.
• 2010
  Rouault H, Mazouni K, Couturier L, Hakim V, Schweisguth F, Genome-wide identification of cis-regulatory motifs and modules underlying gene coregulation using statistics and phylogeny., Proc Natl Acad Sci U S A 2010 Aug; 107(33): 14615-20.
• 2010
  Benhra N, Vignaux F, Dussert A, Schweisguth F, Le Borgne R, Neuralized promotes basal to apical transcytosis of delta in epithelial cells, Mol. Biol. Cell 2010 Jun;21(12):2078-86.
• 2010
  Bardin AJ, Perdigoto CN, Southall TD, Brand AH, Schweisguth F, Transcriptional control of stem cell maintenance in the Drosophila intestine, Development 2010 Mar;137(5):705-14.
• 2010
  Hamel S, Fantini J, Schweisguth F, Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster, J. Cell Biol. 2010 Feb;188(4):581-94.
• 2009
  del Alamo D, Schweisguth F, Notch signalling: receptor cis-inhibition to achieve directionality, Curr. Biol. 2009 Aug;19(16):R683-4.
• 2009
  Chanet S, Vodovar N, Mayau V, Schweisguth F, Genome engineering-based analysis of Bearded family genes reveals both functional redundancy and a nonessential function in lateral inhibition in Drosophila, Genetics 2009 Aug;182(4):1101-8.
• 2009
  Schweisguth F, When you are Dishevelled, fat is good and acid is bad!, Nat. Cell Biol. 2009 Mar;11(3):237-9.
• 2009
  Gomes JE, Corado M, Schweisguth F, Van Gogh and Frizzled act redundantly in the Drosophila sensory organ precursor cell to orient its asymmetric division, PLoS ONE 2009;4(2):e4485.
• 2008
  Perdigoto CN, Gervais L, Overstreet E, Fischer J, Guichet A, Schweisguth F, Overexpression of partner of numb induces asymmetric distribution of the PI4P 5-Kinase Skittles in mitotic sensory organ precursor cells in Drosophila, PLoS ONE 2008;3(8):e3072.
• 2008
  Vodovar N, Schweisguth F, Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?, J. Biol. 2008;7(2):7.
• 2007
  Smith CA, Lau KM, Rahmani Z, Dho SE, Brothers G, She YM, Berry DM, Bonneil E, Thibault P, Schweisguth F, Le Borgne R, McGlade CJ, aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb, EMBO J. 2007 Jan;26(2):468-80.
• 2006
  Petruk S, Sedkov Y, Riley KM, Hodgson J, Schweisguth F, Hirose S, Jaynes JB, Brock HW, Mazo A, Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference, Cell 2006 Dec;127(6):1209-21.
• 2006
  Bardin AJ, Schweisguth F, Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila, Dev. Cell 2006 Feb;10(2):245-55.
• 2005
  Radtke F, Schweisguth F, Pear W, The Notch ‘gospel’, EMBO Rep. 2005 Dec;6(12):1120-5.
• 2005
  David NB, Martin CA, Segalen M, Rosenfeld F, Schweisguth F, Bellaïche Y, Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division, Nat. Cell Biol. 2005 Nov;7(11):1083-90.
• 2005
  Langevin J, Le Borgne R, Rosenfeld F, Gho M, Schweisguth F, Bellaïche Y, Lethal giant larvae controls the localization of notch-signaling regulators numb, neuralized, and Sanpodo in Drosophila sensory-organ precursor cells, Curr. Biol. 2005 May;15(10):955-62.
• 2005
  Schweisguth F, Temporal regulation of planar cell polarity: insights from the Drosophila eye, Cell 2005 May;121(4):497-9.
• 2005
  Le Borgne R, Bardin A, Schweisguth F, The roles of receptor and ligand endocytosis in regulating Notch signaling, Development 2005 Apr;132(8):1751-62.
• 2005
  Le Borgne R, Remaud S, Hamel S, Schweisguth F, Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila, PLoS Biol. 2005 Apr;3(4):e96.
• 2004
  Orgogozo V, Schweisguth F, Evolution of the larval peripheral nervous system in Drosophila species has involved a change in sensory cell lineage, Dev. Genes Evol. 2004 Sep;214(9):442-52.
• 2004
  Schweisguth F, Formation and remodeling of epithelial polarity, Dev. Cell 2004 Jun;6(6):749-55.
• 2004
  Orgogozo V, Schweisguth F, Bellaïche Y, Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila, Mech. Dev. 2004 May;121(5):427-36.
• 2004
  Schweisguth F, [Genetic basis of planar polarity], Med Sci (Paris) 2004 Apr;20(4):424-30.
• 2004
  Bardin AJ, Le Borgne R, Schweisguth F, Asymmetric localization and function of cell-fate determinants: a fly’s view, Curr. Opin. Neurobiol. 2004 Feb;14(1):6-14.
• 2004
  Schweisguth F, Regulation of notch signaling activity, Curr. Biol. 2004 Feb;14(3):R129-38.
• 2004
  Bellaïche Y, Beaudoin-Massiani O, Stuttem I, Schweisguth F, The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila, Development 2004 Jan;131(2):469-78.
• 2003
  Henrique D, Schweisguth F, Cell polarity: the ups and downs of the Par6/aPKC complex, Curr. Opin. Genet. Dev. 2003 Aug;13(4):341-50.
• 2003
  Le Borgne R, Schweisguth F, Unequal segregation of Neuralized biases Notch activation during asymmetric cell division, Dev. Cell 2003 Jul;5(1):139-48.
• 2003
  Le Borgne R, Schweisguth F, Notch signaling: endocytosis makes delta signal better, Curr. Biol. 2003 Apr;13(7):R273-5.
• 2003
  Morel V, Le Borgne R, Schweisguth F, Snail is required for Delta endocytosis and Notch-dependent activation of single-minded expression, Dev. Genes Evol. 2003 Mar;213(2):65-72.
• 2003
  Schweisguth F, [Cell polarity and asymmetric division in the peripheral nervous system of Drosophila], J. Soc. Biol. 2003;197(1):17-22.
• 2002
  Orgogozo V, Schweisguth F, Bellaïche Y, Binary cell death decision regulated by unequal partitioning of Numb at mitosis, Development 2002 Oct;129(20):4677-84.
• 2002
  Le Borgne R, Bellaïche Y, Schweisguth F, Drosophila E-cadherin regulates the orientation of asymmetric cell division in the sensory organ lineage, Curr. Biol. 2002 Jan;12(2):95-104.
• 2001
  Bellaïche Y, Radovic A, Woods DF, Hough CD, Parmentier ML, O'Kane CJ, Bryant PJ, Schweisguth F, The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila, Cell 2001 Aug;106(3):355-66.
• 2001
  Bellaïche Y, Schweisguth F, Lineage diversity in the Drosophila nervous system, Curr. Opin. Genet. Dev. 2001 Aug;11(4):418-23.
• 2001
  Morel V, Lecourtois M, Massiani O, Maier D, Preiss A, Schweisguth F, Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila, Curr. Biol. 2001 May;11(10):789-92.
• 2001
  Orgogozo V, Schweisguth F, Bellaïche Y, Lineage, cell polarity and inscuteable function in the peripheral nervous system of the Drosophila embryo, Development 2001 Mar;128(5):631-43.
• 2001
  Ben-Yaacov S, Le Borgne R, Abramson I, Schweisguth F, Schejter ED, Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling, J. Cell Biol. 2001 Jan;152(1):1-13.
• 2001
  Bellaïche Y, Gho M, Kaltschmidt JA, Brand AH, Schweisguth F, Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division, Nat. Cell Biol. 2001 Jan;3(1):50-7.
• 2000
  Schweisguth F, Cell polarity: fixing cell polarity with Pins, Curr. Biol. 2000 Apr;10(7):R265-7.
• 2000
  Lehembre F, Badenhorst P, Müller S, Travers A, Schweisguth F, Dejean A, Covalent modification of the transcriptional repressor tramtrack by the ubiquitin-related protein Smt3 in Drosophila flies, Mol. Cell. Biol. 2000 Feb;20(3):1072-82.
• 2000
  Morel V, Schweisguth F, Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo, Genes Dev. 2000 Feb;14(3):377-88.
• 1999
  Schweisguth F, Dominant-negative mutation in the beta2 and beta6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage, Proc. Natl. Acad. Sci. U.S.A. 1999 Sep;96(20):11382-6.
• 1999
  Gho M, Bellaïche Y, Schweisguth F, Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell, Development 1999 Aug;126(16):3573-84.
• 1999
  Schweisguth F, Presenilins in their infancy, Chem. Biol. 1999 Jul;6(7):R187-90.
• 1998
  Lecourtois M, Schweisguth F, Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos, Curr. Biol. 1998 Jun;8(13):771-4.
• 1998
  Gho M, Schweisguth F, Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila, Nature 1998 May;393(6681):178-81.
• 1998
  Schweisguth F, Lecourtois M, The activity of Drosophila Hairless is required in pupae but not in embryos to inhibit Notch signal transduction, Dev. Genes Evol. 1998 Mar;208(1):19-27.
• 1997
  Lecourtois M, Schweisguth F, Role of suppressor of hairless in the delta-activated Notch signaling pathway, Perspect Dev Neurobiol 1997;4(4):305-11.
• 1996
  Gho M, Lecourtois M, Géraud G, Posakony JW, Schweisguth F, Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling, Development 1996 Jun;122(6):1673-82.
• 1996
  Schweisguth F, Gho M, Lecourtois M, Control of cell fate choices by lateral signaling in the adult peripheral nervous system of Drosophila melanogaster, Dev. Genet. 1996;18(1):28-39.
• 1995
  Lecourtois M, Schweisguth F, The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling, Genes Dev. 1995 Nov;9(21):2598-608.
• 1995
  Schweisguth F, Suppressor of Hairless is required for signal reception during lateral inhibition in the Drosophila pupal notum, Development 1995 Jun;121(6):1875-84.
• 1995
  Ibnsouda S, Schweisguth F, Jullien D, Kücherer C, Lepesant JA, Vincent A, Evolutionarily conserved positive and negative cis-acting elements control the blastoderm-specific expression of the Drosophila serendipity alpha cellularisation gene, Mech. Dev. 1995 Jan;49(1-2):71-82.
• 1994
  Schweisguth F, Nero P, Posakony JW, The sequence similarity of the Drosophila suppressor of hairless protein to the integrase domain has no functional significance in vivo, Dev. Biol. 1994 Dec;166(2):812-4.
• 1994
  Brou C, Logeat F, Lecourtois M, Vandekerckhove J, Kourilsky P, Schweisguth F, Israël A, Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless, Genes Dev. 1994 Oct;8(20):2491-503.
• 1994
  Schweisguth F, Posakony JW, Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis, Development 1994 Jun;120(6):1433-41.
• 1993
  Ibnsouda S, Schweisguth F, de Billy G, Vincent A, Relationship between expression of serendipity alpha and cellularisation of the Drosophila embryo as revealed by interspecific transformation, Development 1993 Oct;119(2):471-83.
• 1992
  Schweisguth F, Posakony JW, Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates, Cell 1992 Jun;69(7):1199-212.
• 1991
  Grégoire C, Rebaï N, Schweisguth F, Necker A, Mazza G, Auphan N, Millward A, Schmitt-Verhulst AM, Malissen B, Engineered secreted T-cell receptor alpha beta heterodimers, Proc. Natl. Acad. Sci. U.S.A. 1991 Sep;88(18):8077-81.
• 1991
  Schweisguth F, Vincent A, Lepesant JA, Genetic analysis of the cellularization of the Drosophila embryo, Biol. Cell 1991;72(1-2):15-23.
• 1990
  Schweisguth F, Lepesant JA, Vincent A, The serendipity alpha gene encodes a membrane-associated protein required for the cellularization of the Drosophila embryo, Genes Dev. 1990 Jun;4(6):922-31.
• 1989
  Schweisguth F, Yanicostas C, Payre F, Lepesant JA, Vincent A, cis-regulatory elements of the Drosophila blastoderm-specific serendipity alpha gene: ectopic activation in the embryonic PNS promoted by the deletion of an upstream region, Dev. Biol. 1989 Nov;136(1):181-93.