Our group is interested in the development and evolution of brain anatomy. Our main tools are mathematical modelling, magnetic resonance imaging and human genetics. We develop computational neuroanatomy methods base on our theoretical models which we use to analyse the normal diversity of human brain anatomy, as well as to look for differences associated with neurodevelopmental pathologies. We are particularly interested in Autism Spectrum Disorders.
Tools for computational Neuroanatomy
We implement and develop data analysis pipelines to process large neuroimaging-genetics datasets, and participate in the analysis of several very large international consortia. We have developed online and offline interactive tools to examine the […]
Genomic architecture of normal and pathological human neuroanatomical diversity
Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Genome-wide scans looking for associations between genomic polymorphism and neuroanatomical variability identify, however, just a […]
Morphogenesis of neocortical organisation: theoretical and animal models
Neocortical folding is one of the most intriguing characteristics of the mammalian brain. Their pattern is very distinctive for different species, and there seems to be a remarkable relationship between convolutions and the architectonic […]
Patients et chercheurs vers un nouveau dialogue
L’Institut Pasteur, l’Institut Curie et l’Inserm ont organisé le 18 mai 2017 une journée consacrée à l’implication des patients dans la recherche. Environ 80 personnes étaient présentes dont une quarantaine de patients ou de […]
Background on the genetics of ASD
Autism spectrum disorders are a heterogeneous group of pervasive neurodevelopmental disorders affecting approximately 1% of the population. The diagnosis of ASD is based on impairments in reciprocal social communication and stereotyped behaviors. Behind the […]
Phelan McDermid Syndrome: from mechanisms to treatments
Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder with non-specific clinical features. The main symptoms are hypotonia, intellectual disability (ID), absent or delayed speech together with minor dysmorphic features. More than half of the patients […]
Imaginons la recherche
“Imaginons la recherche” is a project for supporting structural change in research organisations to promote Responsible Research and Innovation (RRI) as defined by the european commission : Public engagement (outreach & citizen science) Gender […]
Brain imaging and genetics
Our group is exploring the human brain using Magnetic Resonance Imaging (MRI) and electroencephalogram (EEG). These approaches are combined with our genetic data in order to better understand the genetic and phenotypic diversity of […]
BrainBox (http://brainbox.pasteur.fr) is a web application developed by the Groupe de Neuroanatomie appliquée et théorique de l’Unité de génétique humaine et fonctions cognitives. BrainBox lets you visualise and segment collaboratively any brain MRI dataset available […]
MicroDraw is a web application to visualise and annotate collaboratively high resolution histology data. Annotations are vectorial, and you can use boolean operations to combine, subtract and split regions. You can point MicroDraw to […]
The Brain Catalogue is a collaborative platform for comparative neuroanatomy. Our aim is to celebrate the diversity of the vertebrate brain by making high quality data, open and freely available to everyone. You can […]
2018Measuring and Estimating the Effect Sizes of Copy Number Variants on General Intelligence in Community-Based Samples, JAMA Psychiatry 2018 Mar;.
2018Genome-wide analyses of self-reported empathy: correlations with autism, schizophrenia, and anorexia nervosa, Transl Psychiatry 2018 Mar;8(1):35.
2017A framework to identify contributing genes in patients with Phelan-McDermid syndrome, NPJ Genom Med 2017;2:32.
2017Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition, Mol Psychiatry. 2017 Jun 6..
201511q24.2-25 micro-rearrangements in autism spectrum disorders: Relation to brain structures, Am. J. Med. Genet. A 2015 Dec;167A(12):3019-30.
2015Neuroanatomical Diversity of Corpus Callosum and Brain Volume in Autism: Meta-analysis, Analysis of the Autism Brain Imaging Data Exchange Project, and Simulation, Biol. Psychiatry 2015 Jul;78(2):126-34.
2014Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments, PLoS Genet. 2014 Sep;10(9):e1004580.
2013Progress toward treatments for synaptic defects in autism, Nat. Med. 2013 Jun;19(6):685-94.
2012Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2, Nature 2012 Jun;486(7402):256-60.
2012Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders, PLoS Genet. 2012 Feb;8(2):e1002521.
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