Our group is interested in the development and evolution of brain anatomy. Our main tools are mathematical modelling, magnetic resonance imaging and human genetics. We develop computational neuroanatomy methods base on our theoretical models which we use to analyse the normal diversity of human brain anatomy, as well as to look for differences associated with neurodevelopmental pathologies. We are particularly interested in Autism Spectrum Disorders.
PARIS: Paris Autism Research International Sib-Pair Study
The Paris Autism Research International Sib-pair (PARIS) Study has been launched as a collaborative project by Prof. M. Leboyer (Paris) and Prof. C. Gillberg (Göteborg) in the 2000s. Its main goal is to join […]
Tools for computational Neuroanatomy
We implement and develop data analysis pipelines to process large neuroimaging-genetics datasets, and participate in the analysis of several very large international consortia. We have developed online and offline interactive tools to examine the […]
Genomic architecture of normal and pathological human neuroanatomical diversity
Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Genome-wide scans looking for associations between genomic polymorphism and neuroanatomical variability identify, however, just a […]
Morphogenesis of neocortical organisation: theoretical and animal models
Neocortical folding is one of the most intriguing characteristics of the mammalian brain. Their pattern is very distinctive for different species, and there seems to be a remarkable relationship between convolutions and the architectonic […]
Patients et chercheurs vers un nouveau dialogue
Afin de mieux répondre aux défis de la santé de demain, il est primordial de faire participer les patients aux différentes étapes de la recherche. Cette participation peut avoir lieu à toutes les étapes […]
Background on the genetics of ASD
Autism spectrum disorders (ASD) are a heterogeneous group of pervasive neurodevelopmental disorders affecting approximately 1% of the population. The diagnosis of ASD is based on impairments in reciprocal social communication and stereotyped behaviors. Behind […]
Phelan-McDermid Syndrome: from mechanisms to treatments
Our team identified the first mutations in the SHANK3 gene, showing it’s role in autism and Phelan-McDermid Syndrome (PMS). Thanks to a donation from the French Association of Phelan-McDermid Syndrome, we will continue the […]
Imaginons la recherche
“Imaginons la recherche” is a project for supporting structural change in research organisations to promote Responsible Research and Innovation (RRI) as defined by the european commission : Public engagement (outreach & citizen science) Gender […]
Brain imaging and genetics
Our group is exploring the human brain using Magnetic Resonance Imaging (MRI) and electroencephalogram (EEG). These approaches are combined with our genetic data in order to better understand the genetic and phenotypic diversity of […]
BrainBox (http://brainbox.pasteur.fr) is a web application developed by the Groupe de Neuroanatomie appliquée et théorique de l’Unité de génétique humaine et fonctions cognitives. BrainBox lets you visualise and segment collaboratively any brain MRI dataset available […]
MicroDraw is a web application to visualise and annotate collaboratively high resolution histology data. Annotations are vectorial, and you can use boolean operations to combine, subtract and split regions. You can point MicroDraw to […]
The Brain Catalogue is a collaborative platform for comparative neuroanatomy. Our aim is to celebrate the diversity of the vertebrate brain by making high quality data, open and freely available to everyone. You can […]
2020Polygenic Architecture of Human Neuroanatomical Diversity., Cereb Cortex 2020 Apr; 30(4): 2307-2320.
2019Genetic architecture of subcortical brain structures in 38,851 individuals, Nat. Genet. 2019 11;51(11):1624-1636.
2019Social and non-social autism symptoms and trait domains are genetically dissociable, Commun Biol 2019 Sep;2(1):328.
2019Social and non-social autism symptoms and trait domains are genetically dissociable, Commun Biol 2019;2:328.
2019Comparison between diffusion MRI tractography and histological tract-tracing of cortico-cortical structural connectivity in the ferret brain, Netw Neurosci 2019;3(4):1038-1050.
2019Evolution of neocortical folding: A phylogenetic comparative analysis of MRI from 34 primate species, Cortex 2019 Sep;118:275-291.
2019Sex Differences Along the Autism Continuum: A Twin Study of Brain Structure, Cereb. Cortex 2019 03;29(3):1342-1350.
2019Morning Plasma Melatonin Differences in Autism: Beyond the Impact of Pineal Gland Volume, Front Psychiatry. 2019 Feb 6;10:11.
2019Role of mechanical morphogenesis in the development and evolution of the neocortex, Phys Life Rev 2019 Dec;31:233-239.
2018Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project, Biol Psychiatry Cogn Neurosci Neuroimaging 2019 03;4(3):260-270.
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