Our group is interested in the development and evolution of brain anatomy. Our main tools are mathematical modelling, magnetic resonance imaging and human genetics. We develop computational neuroanatomy methods base on our theoretical models which we use to analyse the normal diversity of human brain anatomy, as well as to look for differences associated with neurodevelopmental pathologies. We are particularly interested in Autism Spectrum Disorders.
PARIS: Paris Autism Research International Sib-Pair Study
The Paris Autism Research International Sib-pair (PARIS) Study has been launched as a collaborative project by Prof. M. Leboyer (Paris) and Prof. C. Gillberg (Göteborg) in the 2000s. Its main goal is to join […]
Tools for computational Neuroanatomy
We implement and develop data analysis pipelines to process large neuroimaging-genetics datasets, and participate in the analysis of several very large international consortia. We have developed online and offline interactive tools to examine the […]
Genomic architecture of normal and pathological human neuroanatomical diversity
Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Genome-wide scans looking for associations between genomic polymorphism and neuroanatomical variability identify, however, just a […]
Morphogenesis of neocortical organisation: theoretical and animal models
Neocortical folding is one of the most intriguing characteristics of the mammalian brain. Their pattern is very distinctive for different species, and there seems to be a remarkable relationship between convolutions and the architectonic […]
Patients et chercheurs vers un nouveau dialogue
Afin de mieux répondre aux défis de la santé de demain, il est primordial de faire participer les patients aux différentes étapes de la recherche. Cette participation peut avoir lieu à toutes les étapes […]
Background on the genetics of ASD
Autism spectrum disorders (ASD) are a heterogeneous group of pervasive neurodevelopmental disorders affecting approximately 1% of the population. The diagnosis of ASD is based on impairments in reciprocal social communication and stereotyped behaviors. Behind […]
Phelan-McDermid Syndrome: from mechanisms to treatments
Our team identified the first mutations in the SHANK3 gene, showing it’s role in autism and Phelan-McDermid Syndrome (PMS). Thanks to a donation from the French Association of Phelan-McDermid Syndrome, we will continue the […]
Imaginons la recherche
“Imaginons la recherche” is a project for supporting structural change in research organisations to promote Responsible Research and Innovation (RRI) as defined by the european commission : Public engagement (outreach & citizen science) Gender […]
Brain imaging and genetics
Our group is exploring the human brain using Magnetic Resonance Imaging (MRI) and electroencephalogram (EEG). These approaches are combined with our genetic data in order to better understand the genetic and phenotypic diversity of […]
BrainBox (http://brainbox.pasteur.fr) is a web application developed by the Groupe de Neuroanatomie appliquée et théorique de l’Unité de génétique humaine et fonctions cognitives. BrainBox lets you visualise and segment collaboratively any brain MRI dataset available […]
MicroDraw is a web application to visualise and annotate collaboratively high resolution histology data. Annotations are vectorial, and you can use boolean operations to combine, subtract and split regions. You can point MicroDraw to […]
The Brain Catalogue is a collaborative platform for comparative neuroanatomy. Our aim is to celebrate the diversity of the vertebrate brain by making high quality data, open and freely available to everyone. You can […]
2022Insights from an autism imaging biomarker challenge: Promises and threats to biomarker discovery., Neuroimage 2022 Apr; 255(): 119171.
2021Sex differences in the brain are not reduced to differences in body size., Neurosci Biobehav Rev 2021 11; 130(): 509-511.
2021Neuroanatomical norms in the UK Biobank: The impact of allometric scaling, sex, and age., Hum Brain Mapp 2021 Oct; 42(14): 4623-4642.
2021Centering inclusivity in the design of online conferences-An OHBM-Open Science perspective., Gigascience 2021 Aug; 10(8): .
2021Brainhack: Developing a culture of open, inclusive, community-driven neuroscience., Neuron 2021 06; 109(11): 1769-1775.
2021Imaging evolution of the primate brain: the next frontier?, Neuroimage 2021 03; 228(): 117685.
2021A collaborative resource platform for non-human primate neuroimaging., Neuroimage 2021 02; 226(): 117519.
2020Adjusting for allometric scaling in ABIDE I challenges subcortical volume differences in autism spectrum disorder., Hum Brain Mapp 2020 11; 41(16): 4610-4629.
2020Neuroanatomy of dyslexia: An allometric approach., Eur J Neurosci 2020 09; 52(6): 3595-3609.
2020The social brain in female autism: a structural imaging study of twins., Soc Cogn Affect Neurosci 2020 06; 15(4): 423-436.
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