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© Institut Pasteur
Corne d'Ammon (ou hippocampe) de renard atteint de rage sauvage. Coloration avec un conjugué fluorescent sur la nucléocapside du virus.

About

Florence Larrous, Research Engineer in “Dynamic of  Lyssavirus and adaptation to host” unit is involved in public health activities for animal and human rabies diagnosis but also in several research topics. She is responsible for the technical and scientific co-supervision of many trainees (master, phD students…). Her thesis supported in September 2013 focused on the role of Lyssavirus matrix protein and phosphoprotein in the innate immunity and efficacy of the replication complex.

Research topics:

 Understanding how the viral matrix and phosphoprotein modulate the viral-host interplay and in particular the innate immune response.

Identification of viral molecular drivers of replication and transcription efficiency: how mutations of rabies phosphoprotein affect replication complex activity and induce emergence of new viral population

Develop new inhibitors of rabies infection: description of new molecules targeting the replication complex of lyssaviruses or more largely the replication of Mononegavirales.

Decipher the Mononegavirales capping machinery by characterizing the structure and the function of capping enzymes (PRNTase, N7- and 2’O-MTases).

Identification of compounds blocking the MTase activity leading to the discovery of a viral strategy that links transcription to immune evasion. 

Development of a novel combined prophylactic/therapeutic approach for rabies

 

Projects

CV

Florence LARROUS, PhD, IP

EDUCATION

     2013                    PhD thesis, Microbiology, University Paris Diderot (Paris VII)

     1990                    BTS Biotechnology, ENCPB, Paris 13

RESEARCH and PRofessional EXPERIENCE

     2014- present       Research engineer in DyLah Unit,

     2000-2013           Technician in DyLah Unit (Pasteur Institut)

     1990-2000           Technician in Texcell (Pasteur Institut)

SCIENTIFIC ACTIVITIES

     19 publications, 1 international patent  – Hisch h index : 13

ADMINISTRATIVE RESPONSIBILITIES and EXPERTISE

– Technical competencies:

     Virology, cellular and molecular biology

     Reverse genetic on negative strand RNA virus

     Public health activities on rabies diagnosis

     Work according to quality assurance (AFNOR ISO17025 and ISO15189)

– Coaching competencies:

     Supervision of license or master students

     Participation in coaching of PhD students

     Technical manager for technician for rabies diagnosis activities

– Main research project:

     Study of molecular targets for the development of new antiviral strategies (replication complex of lyssaviruses).

     Role of the M and P proteins in the host-lyssavirus interplay

MOST SIGNIFICANT PUBLICATION IN THE LAST FIVE YEARS

  • Ben Khalifa Y*, Luco S*, Besson B, Sonthonnax F, Archambaud M, Grimes JM, Larrous F Bourhy H; The matrix protein of rabies virus binds to RelAp43 to modulate NF-κB-dependent gene expression related to innate immunity. Sci Rep. 2016 Dec 21;6:39420.
  • Dacheux L*., Larrous F.*, Lavenir R, Lepelletier A, Faouzi A, Troupin C, Nourlil J, Buchy P, Bourhy H ; Dual Combined Real-Time Reverse Transcriptase Polymerase Chain Reaction Assay for the Diagnosis of Lyssavirus Infection ; PLoS Negl Trop Dis. LoS Negl Trop Dis. 2016 Jul 5;10(7)
  • de Thoisy B, Bourhy H, Delaval M, Pontier D, Dacheux L, Darcissac E, Donato D,Guidez A, Larrous F, Lavenir R, Salmier A, Lacoste V, Lavergne A. Bioecological ; Drivers of Rabies Virus Circulation in a Neotropical Bat Community. PLoS Negl Trop Dis. 2016 Jan 25;10(1).
  • Contou D, Dacheux L, Bendib I, Jolivet S, Rodriguez C, Tomberli F, Cleret de Langavant L, Lavenir R, Lepelletier A, Larrous F, Troupin C, Bourhy H,Brun-Buisson C. Severe ketoalkalosis as initial presentation of imported human rabies in France. J Clin Microbiol. 2015 June;53(6):1979-82.
  • Fouquet B, Nikolic J, Larrous F, Bourhy H, Wirblich C, Lagaudrière-Gesbert C, Blondel D. Focal adhesion kinase is involved in rabies virus infection through its interaction with viral phosphoprotein P. J Virol. 2015 Feb;89(3):1640-51.
  • Wiltzer L, Okada K, Yamaoka S, Larrous F, Kusisto HV, Sugiyama M, Blondel D, Bourhy H, Jans DA, Ito N, Moseley GW. Interaction of Rabies Virus P-Protein With STAT Proteins is Critical to Lethal Rabies Disease. J Infect. Dis. (2014) 209 (11): 1744-1753.