MOOC Viruses and Human Cancers
The MOOC offers a broad overview of the state of knowledge on viruses associated with cancer, the different mechanisms of carcinogenesis, the host immune response and progress in preventing tumors. Registration on: https://www.fun-mooc.fr/en/courses/viruses-and-human-cancers/ […]
Major Federating Program Vaccinology
General concept The Major Federating Program (Grand Programme Fédérateur, GPF) Vaccinology is one of three large-scale horizontal GPFs implemented by Institut Pasteur. The GPFs aim to unite forces at Institut Pasteur and in the […]
300 to 400 million cases of dengue fever occur each year worldwide. Spreading rapidly, more than 40% of the world’s population is now at risk of contracting dengue This transversal program brings together talents […]
Towards understanding of immunostimulatory properties of SARS-CoV-2 RNAs
Summary COVID-19 represents a massive health threat for humans and has already caused huge economic problems all over the world. Profound knowledge of SARS-CoV-2 interaction with the host and the host immune response are […]
Group for AIDS Research
The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes bimonthly meetings and seminars around an HIV / AIDS research topic. Since 2021, the meetings may also include topics related to emerging viruses. […]
GPF Vaccinology Call 1: Open call for new ideas for cutting-edge science investigations in vaccinology.
The purpose of this call for ideas is to solicit community input for original, cutting-edge science investigations that are consistent with the Institut Pasteur’s new development strategy in vaccinology. The “Open Pasteur vaccine challenge” […]
GPF Vaccinology Call 2: Accelerating Preclinical Development of Vaccine Candidates
With the second call, the GPF Vaccinology aims at identifying ongoing preclinical projects aiming to develop vaccine candidates at Institut Pasteur, including the International Network. The objective of the GPF call is to help […]
Comics on vaccination
The Center for Translational Science, the Center Medical Institut Pasteur (CMIP) and the major federating program (GPF) vaccinology welcome for one year a science illustrator, Celia Ducaju, in partnership with the Ecole Estienne School […]
Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)
A thousand fold improvement of an antiviral activity The starting point of this project was the modest activity displayed by compounds 1 and 2, on the phenotypic Measles-based antiviral assay designed by Pierre-Olivier Vidalain […]
Bivalent vaccines derived from measles vaccine
Bivalent vaccines derived from measles vaccine (F. Tangy, N. Escriou) Major childhood diseases, such as polio or measles, have been virtually eliminated since the 60s thanks to the use of live-attenuated vaccines. Today, millions […]
A dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection (E14305984.8)
The present invention is directed to a dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection. The present invention provides means, in […]
2022Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1., iScience 2022 Jul; 25(7): 104599.
2022Discovery of Genes that Modulate Flavivirus Replication in an Interferon-Dependent Manner., J Mol Biol 2022 03; 434(6): 167277.
2021sgDI-tector: defective interfering viral genome bioinformatics for detection of coronavirus subgenomic RNAs., RNA 2021 Dec; (): .
2021A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters., Nat Commun 2021 11; 12(1): 6277.
2021A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains., Sci Transl Med 2021 Jun; 13(597): .
2021Proteomic Analysis Uncovers Measles Virus Protein C Interaction with p65/iASPP Protein Complex., Mol Cell Proteomics 2021 Jan; (): 100049.
2020Retinoic Acid Inducible Gene I and Protein Kinase R, but Not Stress Granules, Mediate the Proinflammatory Response to Yellow Fever Virus., J Virol 2020 10; 94(22): .
2019Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen., Viruses 2019 01; 11(1): .
2018DI-tector: defective interfering viral genomes’ detector for next-generation sequencing data., RNA 2018 10; 24(10): 1285-1296.
2018RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes., Cell Rep. 2018 Jul 10;24(2):320-328.
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