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© A-M. Pais-Correia, M-I. Thoulouze, A. Alcover, A. Gessain
Mise en évidence de structures de type "biofilm ", formées par le rétrovirus HTLV-1 générés par des cellules infectées (cellules du haut), qui ont été transmis à un autre lymphocyte (cellule du bas). Micrographie en microscopie électronique à balayage. Image colorisée.
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About

Pierre-Emmanuel Ceccaldi obtained a Ph .D in Neuroscience at the Université Pierre et Marie Curie in 1989, on the axonal transport of Rabies Virus.

After a post-doctoral training (EMBO Fellowship) at the University of Milan/San Raffaele Institute (Milan, Italy) on the role of synapsin-I in neurotransmitter release, he joined in 1993 the Rabies Unit of the Pasteur Institute (Paris), as Permanent Researcher, where he developed different studies on the neurotropism, neurovirulence and neuroinvasion of rabies virus as well as other neurotropic viruses such as West Nile virus.

In 2003 he joined the Epidemiology and Physiopathology of Oncogenic Viruses where he has been performing studies on HTLV-1 interactions and crossing of the Blood-Brain Barrier as well as the intestinal barrier, using in vitro as well as ex-vivo models. He has been also developing studies about the interactions of different viruses with the muscle cells, in the context of viral induced myopathies. These study take advantage of primary human muscle cells in culture (myoblasts and myotubes), in collaboration with Myology Institute (Paris) and clinicians from different hospitals, and involve HTLV-1, Chikungunya, Sindbis and influenza viruses. He is Professor at the University Paris Diderot since 2009 and Co-Director of the Basic Virology Course of the Pasteur Institute since 2010.

Pierre-Emmanuel Ceccaldi still participates to the study concerning interactions of HTLV-1 with the Blood-Brain Barrier, now conducted by Philippe Afonso. In collaboration with Aurore Vidy, recruited as Assistant Professor in the Team in 2014, studies are conducted on the interactions and crossing of the HTLV-1 virus with the intestinal barrier, both on in vitro, ex vivo and animal models. Another topic of research concern the interaction of viruses with muscle cells, focusing on HTLV-1 and Chikungunya viruses, and especially the study of viral susceptibilty during muscle cell differentiation, as well as the effect of viral infection on muscle cell differentiation and regeneration.

 

 

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