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Understanding viral attenuation for the rationalization of vaccine design
Nolwenn Jouvenet (PI)
Vaccination is one of the greatest successes of modern medicine. The first generation of viral vaccines relied on empiric attenuation by repeated passage in animals and/or cultured cells. A successful attenuation process eliminates virulence […]
2020The inflammasome components NLRP3 and ASC act in concert with IRGM to rearrange the Golgi during HCV infection., J Virol 2020 Nov; (): .
2020A comparison of four serological assays for detecting anti-SARS-CoV-2 antibodies in human serum samples from different populations., Sci Transl Med 2020 09; 12(559): .
2020RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to yellow fever virus., J. Virol. 2020 Sep; (): .
2019Atlastin Endoplasmic Reticulum-Shaping Proteins Facilitate Zika Virus Replication., J. Virol. 2019 12; 93(23): .
2019Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells., Nat Commun 2019 09; 10(1): 4430.
2018RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes., Cell Rep. 2018 Jul 10;24(2):320-328.
2016Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses., mBio 2016 Feb; 7(1): e01956-15.