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  • program_project
  • nrc
  • whocc
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  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Department Manager
  • Full Professor
  • Graduate Student
  • Lab assistant
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  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
03
Sep 2021
Ending Date
31
Oct 2021
Time
09:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
2021-09-03 09:00:00 2021-10-31 22:00:00 Europe/Paris MOOC Viruses and Human Cancers The MOOC offers a broad overview of the state of knowledge on viruses associated with cancer, the different mechanisms of carcinogenesis, the host immune response and progress in preventing tumors. Registration on: https://www.fun-mooc.fr/en/courses/viruses-and-human-cancers/   […] Institut Pasteur, Rue du Docteur Roux, Paris, France Jean-Pierre Vartanian jean-pierre.vartanian@pasteur.fr

The MOOC offers a broad overview of the state of knowledge on viruses associated with cancer, the different mechanisms of carcinogenesis, the host immune response and progress in preventing tumors.

 

At the end of this course, you will be able to:

  • Learn about the biology and the replicative cycle of viruses associated with cancers
  • Know the mechanism of tumorigenesis induced by these viruses
  • Understand the role of the immune system in controlling these viruses and the induced tumors
  • Be at the cutting edge of new advances in terms of vaccination and anti-tumor therapies.

Description

About 20% of human cancers are induced by viruses, particularly in low/middle income countries, to a point that in some regions of the world, viral infection is the main etiology of human cancers. Our understanding of the relationship between viral infection and oncogenesis has considerably improved during the last two decades. As obligatory intracellular parasites, viruses encode proteins that reprogram host cellular signaling pathways that control proliferation, differentiation, cell death, genomic integrity, and recognition by the immune system. Both DNA and RNA viruses have been linked with human cancers.

Epstein-Barr virus, papillomaviruses, hepatitis B virus, human herpesvirus-8 and Merkel cell polyomavirus are the five DNA viruses that are capable of causing the development of human cancers. Human T lymphotrophic virus type 1 and hepatitis C virus are the two RNA viruses that contribute to human cancers. Treatment and prevention strategies critically depend on the double understanding of the mechanism of cell tumorigenesis and the way they are influenced by viruses.

During this MOOC, we will review the different mechanisms of virus induced carcinogenesis, from direct integration of the virus in the genome to non-specific inflammation and immune disorders. The epidemiology and specificity of each type of virus and of the induced tumor will then be given in detail. At the end we will report innovations in the prevention of virus induced tumors.

Pôle Enseignement Numérique

Location

Location: Institut Pasteur, Rue du Docteur Roux, Paris, France