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  • Director of Center
  • Director of Department
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© Gail Rozen-Gagnon, Christine Schmitt,
Cells infected with Chikungunya (CHIK) virus.
Scientific Fields
Diseases
Organisms
Applications
Technique

About

Flavivirus NS1 is involved in the intracellular stages of virus replication. It also circulates in the extracellular medium although its related function remains unknown. We have developed a dengue diagnostic kit based on the NS1 antigen capture by ELISA that has become a reference in the field since its commercialization by BioRad in 2006. We are currently pursuing the functional characterization of the secreted form of dengue virus NS1 in an attempt to specify its contribution to fatal hemorrhagic fevers.

Projects

Project
Ongoing
9 Members

Host genetic susceptibility to Zika virus

Xavier Montagutelli (PI)

Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis […]
Project
Ongoing
5 Members

Understanding protective humoral immunity in asymptomatic dengue-infected individuals

Tineke Cantaert (PI)

Dengue is caused by dengue virus (DENV), a virus which can be transmitted by Aedes mosquitos. Half of the world’s population live in areas where the mosquito and the virus are circulating. Infection by […]
Project
Ongoing
16 Members

Pasteur International Center for Research on Emerging Infectious Diseases

Anavaj Sakuntabhai (PI)

We established an Emerging Infectious Disease Research Center in Southeast Asia and West/Central Africa with an inter-continental one-health approach designed to improve the capacity to respond rapidly and effectively to outbreaks. We built on […]
Project
Ongoing
8 Members

Pathogenicity and resistance to Rift Valley Fever virus.

Xavier Montagutelli (PI)

Rift Valley fever (RVF) is a an arthropod-borne emerging viral disease that primarily affects domesticated animals (such as cattle, sheep and goats) and humans, with recent outbreaks in sub-Saharan Africa, Madagascar, and the Arabian […]
Project
Ongoing
2 Members

Viral toxins

Marie Flamand (PI)

Biological study of secreted dengue virus nonstructural protein NS1 Flavivirus NS1 is involved in the intracellular stages of virus replication. It also circulates in the extracellular medium although its related function remains unknown. We […]

Publications

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