Marie FLAMAND leads a research group in the Structural Virology Lab at Institut Pasteur Paris. The team investigates several arboviruses that significantly impact human health, including dengue (DEN), Zika, and Rift Valley fever (RVF) viruses. Their main line of research focuses on the role of accessory proteins in viral pathogenesis. This led to the identification of two key virulence factors: the mitochondrial RVFV NSm protein and the secreted DEN NS1 nonstructural protein. Notably, her team demonstrated that NS1 circulates in the bloodstream during acute DENV infections, establishing it as a potent diagnostic marker. A diagnostic kit based on NS1 antigen detection, developed at the Institut Pasteur, has become a gold standard reference in the field. More recently, the team revealed that secreted NS1 forms a pro-inflammatory complex with human high-density lipoproteins (HDL), highlighting its significant contribution to the cytokine storm associated with dengue hemorrhagic fever.
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2025Prolonged Zika Virus NS1 Protein Circulation in Patient Sera Impacts Clinical Outcome Before the Rise of a Specific IgM Response., J Med Virol 2025 May; 97(5): e70368.
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2022Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins., EMBO Rep 2022 May; (): e53600.
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2021Identification of Umbre Orthobunyavirus as a Novel Zoonotic Virus Responsible for Lethal Encephalitis in 2 French Patients with Hypogammaglobulinemia., Clin Infect Dis 2021 May; 72(10): 1701-1708.
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2020Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis., Sci Rep 2020 May; 10(1): 8734.
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2020Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b., J Virol 2020 01; 94(3): .
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2015The flavivirus NS1 protein’s mysteries unveiled?: (Comment on DOI 10.1002/bies.201400182), Bioessays 2015 May;37(5):472.
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2014The Rift Valley fever accessory proteins NSm and P78/NSm-GN are distinct determinants of virus propagation in vertebrate and invertebrate hosts, Emerg Microbes Infect 2014 Oct;3(10):e71.
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2013Role of the cytosolic tails of Rift Valley fever virus envelope glycoproteins in viral morphogenesis, Virology 2014 Jan;448:1-14.
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2006Evaluation of an enzyme immunoassay for detection of dengue virus NS1 antigen in human serum, Clin. Vaccine Immunol. 2006 Nov;13(11):1185-9.
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2005The secreted form of dengue virus nonstructural protein NS1 is endocytosed by hepatocytes and accumulates in late endosomes: implications for viral infectivity, J. Virol. 2005 Sep;79(17):11403-11.
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