Flavivirus NS1 is involved in the intracellular stages of virus replication. It also circulates in the extracellular medium although its related function remains unknown. We have developed a dengue diagnostic kit based on the NS1 antigen capture by ELISA that has become a reference in the field since its commercialization by BioRad in 2006. We are currently pursuing the functional characterization of the secreted form of dengue virus NS1 in an attempt to specify its contribution to fatal hemorrhagic fevers.
Click to view graph
Connections
Click to view timeline
Timeline
Transversal Projects
Projects
Publications
Download-
2022Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins., EMBO Rep 2022 May; (): e53600.
-
2020Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis., Sci Rep 2020 May; 10(1): 8734.
-
2020Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b., J Virol 2020 01; 94(3): .
-
2015The flavivirus NS1 protein’s mysteries unveiled?: (Comment on DOI 10.1002/bies.201400182), Bioessays 2015 May;37(5):472.
-
2014The Rift Valley fever accessory proteins NSm and P78/NSm-GN are distinct determinants of virus propagation in vertebrate and invertebrate hosts, Emerg Microbes Infect 2014 Oct;3(10):e71.
-
2013Role of the cytosolic tails of Rift Valley fever virus envelope glycoproteins in viral morphogenesis, Virology 2014 Jan;448:1-14.
-
2006Evaluation of an enzyme immunoassay for detection of dengue virus NS1 antigen in human serum, Clin. Vaccine Immunol. 2006 Nov;13(11):1185-9.
-
2005The secreted form of dengue virus nonstructural protein NS1 is endocytosed by hepatocytes and accumulates in late endosomes: implications for viral infectivity, J. Virol. 2005 Sep;79(17):11403-11.
-
2002Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections, J. Clin. Microbiol. 2002 Feb;40(2):376-81.