300 à 400 millions de cas de dengue surviennent chaque année dans le monde entier. Se diffusant rapidement, plus de 40% de la population mondiale est maintenant à risque de contracter la dengue. Ce […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation Le but du projet Biologie Intégrative des Maladies Infectieuses Emergentes (IBEID), coordonné par les professeurs Philippe Sansonetti et Pascale Cossart, est de développer une structure pour anticiper et lutter contre les maladies […]
PTR2020-353 ZOOFOAMENV – Host pathogens interactions in humans infected with zoonotic foamy viruses
General context : Foamy viruses (FV) are the oldest retroviruses, described as largely nonpathogenic in their natural animal hosts. Simian foamy viruses (SFVs) can be transmitted to humans, where they establish persistent infection akin […]
Pasteur International Center for Research on Emerging Infectious Diseases
We established an Emerging Infectious Disease Research Center in Southeast Asia and West/Central Africa with an inter-continental one-health approach designed to improve the capacity to respond rapidly and effectively to outbreaks. We built on […]
TITLE: CORONABODIES : Production of SARS-CoV-2 nucleoprotein (N) and spike (S) recombinant antigens and generation of anti-N and anti-S nanobodies for diagnostic and therapeutic applications. SUMMARY We propose a joint effort to generate as […]
Emergency response to global threats of emerging and re-emerging pathogens
With over 125 years’ experience with infectious diseases, the Institut Pasteur and the Institut Pasteur International Network (IPIN), which is composed of 33 research institutes in 26 countries and five continents, are ideally positioned […]
Cell-Cell fusion in fertilization and developmental biology: a structural biology approach. My group has made seminal contributions in the past toward understanding the mechanism of membrane fusion used by enveloped viruses to infect a […]
DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe
The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
Protein Data Bank depositions
PDB Crystal Structures Resolution (A) Year NON-VIRAL proteins Eukariotyc cell-cell fusion 4OJC Wild-type full-length trimeric ectodomain of C. elegans fusion protein EFF-1 2.93 2014 4OJD C-ter truncated trimeric ectodomain of C. elegans fusion protein […]
Rubella virus E1 envelope glycoprotein
Little is known about the three-dimensional organization of rubella virus, which causes a relatively mild measles-like disease in children but leads to serious congenital health problems when contracted in utero. Although rubella virus […]
Respiratory Syncytial virus
Respiratory Syncytial Virus Nucleoprotein-RNA complex Human respiratory syncytial virus (RSV) is the most important viral agent of pediatric respiratory tract disease worldwide, causing pneumonia and bronchiolitis in infants. No vaccine is currently […]
Picobirnavirus capsid protein
Double-stranded (ds) RNA virus particles are organized around a central icosahedral core capsid made of 120 identical subunits. This core capsid is unable to invade cells from outside, and animal dsRNA viruses have […]
Bovine Viral Diarrhea virus envelop protein E(rns) Pestiviruses, which belong to the Flaviviridae family of RNA viruses, are important agents of veterinary diseases causing substantial economical losses in animal farming worldwide. Pestivirus particles display […]
Herpesviruses envelop glycoproteins Herpesviridae are a large family of double-stranded DNA viruses, counting more than 200 members that infect humans and a wide range of invertebrates and vertebrates. Herpesviruses carry a […]
Hepatitis C virus
Hepatitis C virus E2 envelop glycoprotein The hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide, leading to cirrhosis and hepatocellular carcinoma. In spite of being the focus […]
Dengue virus E envelop glycoprotein The dengue virus (DENV) is a mosquito-borne member of the flavivirus genus responsible for roughly 50 million human infections each year. DENV is composed of four distinct but […]
Chikungunya virus p62-E1 envelope glycoproteins The Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that has caused widespread outbreaks of a debilitating human disease in the last 5 years. CHIKV invasion of susceptible cells […]
C. elegans Eff-1
Cell-cell fusion proteins are essential in development. We show that the C. elegans cell-cell fusion protein EFF-1 is structurally homologous to viral class II fusion proteins. The 2.6 Ang. crystal structure of the […]
Lymphocytic choriomeningitis virus GP2 envelop protein Arenaviruses are important agents of zoonotic disease worldwide. The virions expose a tripartite envelope glycoprotein complex (GPC) at their surface, formed by the glycoprotein subunits GP1, GP2 and […]
Chikungunya virus pathogenesis
Structural and functional studies of Chikungunya virus entry into host cells Deciphering Chikungunya virus cell biology by high-throughput / high-content screening Chikungunya virus infection of fibroblasts Chikungunya virus and the central nervous system infection
2021Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization., Nature 2021 Jul; (): .
2020The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism., Cell 2020 Sep; (): .
2020A comparison of four serological assays for detecting anti-SARS-CoV-2 antibodies in human serum samples from different populations., Sci Transl Med 2020 09; 12(559): .
2020A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications., C R Biol 2020 Jun; 343(1): 33-39.
2020Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein., Nat Commun 2020 01; 11(1): 596.
2019X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications., J Mol Biol 2019 12; 431(24): 4922-4940.
2017The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein., Cell. 2017 Feb 23;168(5):904-915.e10. doi: 10.1016/j.cell.2017.01.024..
2015A replication defect of pseudorabies virus induced by targeted α-helix distortion in the syntaxin-like bundle of glycoprotein H (V275P) is corrected by an adjacent compensatory mutation (V271A)., J Gen Virol 2015 Aug; 96(8): 2349-2354.
2015X-ray structure of the pestivirus NS3 helicase and its conformation in solution, J. Virol. 2015 Apr;89(8):4356-71.
2015Recognition determinants of broadly neutralizing human antibodies against dengue viruses, Nature 2015 Apr;520(7545):109-13.
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