Résistance aux agents antimicrobiens
La résistance aux agents antimicrobiens augmente de façon spectaculaire dans le monde entier, menaçant la santé publique à court terme. Il devient urgent d’agir afin d’inverser la courbe d’augmentation de la résistance et de […]
300 à 400 millions de cas de dengue surviennent chaque année dans le monde entier. Se diffusant rapidement, plus de 40% de la population mondiale est maintenant à risque de contracter la dengue. Ce […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation Le but du projet Biologie Intégrative des Maladies Infectieuses Emergentes (IBEID), coordonné par les professeurs Philippe Sansonetti et Pascale Cossart, est de développer une structure pour anticiper et lutter contre les maladies […]
(EN) Foamy virus Env protein – where virus meets the cells and host immune system
PTR2020-353 ZOOFOAMENV – Host pathogens interactions in humans infected with zoonotic foamy viruses
General context : Foamy viruses (FV) are the oldest retroviruses, described as largely nonpathogenic in their natural animal hosts. Simian foamy viruses (SFVs) can be transmitted to humans, where they establish persistent infection akin […]
Pasteur International Center for Research on Emerging Infectious Diseases
We established an Emerging Infectious Disease Research Center in Southeast Asia and West/Central Africa with an inter-continental one-health approach designed to improve the capacity to respond rapidly and effectively to outbreaks. We built on […]
TITLE: CORONABODIES : Production of SARS-CoV-2 nucleoprotein (N) and spike (S) recombinant antigens and generation of anti-N and anti-S nanobodies for diagnostic and therapeutic applications. SUMMARY We propose a joint effort to generate as […]
Cell-Cell fusion in fertilization and developmental biology: a structural biology approach. My group has made seminal contributions in the past toward understanding the mechanism of membrane fusion used by enveloped viruses to infect a […]
DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe
The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
Protein Data Bank depositions
PDB Crystal Structures Resolution (A) Year NON-VIRAL proteins Eukariotyc cell-cell fusion 4OJC Wild-type full-length trimeric ectodomain of C. elegans fusion protein EFF-1 2.93 2014 4OJD C-ter truncated trimeric ectodomain of C. elegans fusion protein […]
Rubella virus E1 envelope glycoprotein
Little is known about the three-dimensional organization of rubella virus, which causes a relatively mild measles-like disease in children but leads to serious congenital health problems when contracted in utero. Although rubella virus […]
Respiratory Syncytial virus
Respiratory Syncytial Virus Nucleoprotein-RNA complex Human respiratory syncytial virus (RSV) is the most important viral agent of pediatric respiratory tract disease worldwide, causing pneumonia and bronchiolitis in infants. No vaccine is currently […]
Picobirnavirus capsid protein
Double-stranded (ds) RNA virus particles are organized around a central icosahedral core capsid made of 120 identical subunits. This core capsid is unable to invade cells from outside, and animal dsRNA viruses have […]
Bovine Viral Diarrhea virus envelop protein E(rns) Pestiviruses, which belong to the Flaviviridae family of RNA viruses, are important agents of veterinary diseases causing substantial economical losses in animal farming worldwide. Pestivirus particles display […]
Herpesviruses envelop glycoproteins Herpesviridae are a large family of double-stranded DNA viruses, counting more than 200 members that infect humans and a wide range of invertebrates and vertebrates. Herpesviruses carry a […]
Hepatitis C virus
Hepatitis C virus E2 envelop glycoprotein The hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide, leading to cirrhosis and hepatocellular carcinoma. In spite of being the focus […]
Dengue virus E envelop glycoprotein The dengue virus (DENV) is a mosquito-borne member of the flavivirus genus responsible for roughly 50 million human infections each year. DENV is composed of four distinct but […]
Chikungunya virus p62-E1 envelope glycoproteins The Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that has caused widespread outbreaks of a debilitating human disease in the last 5 years. CHIKV invasion of susceptible cells […]
C. elegans Eff-1
Cell-cell fusion proteins are essential in development. We show that the C. elegans cell-cell fusion protein EFF-1 is structurally homologous to viral class II fusion proteins. The 2.6 Ang. crystal structure of the […]
Lymphocytic choriomeningitis virus GP2 envelop protein Arenaviruses are important agents of zoonotic disease worldwide. The virions expose a tripartite envelope glycoprotein complex (GPC) at their surface, formed by the glycoprotein subunits GP1, GP2 and […]
Chikungunya virus pathogenesis
Structural and functional studies of Chikungunya virus entry into host cells Deciphering Chikungunya virus cell biology by high-throughput / high-content screening Chikungunya virus infection of fibroblasts Chikungunya virus and the central nervous system infection
2023Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein., Cell Rep 2023 Feb; 42(3): 112142.
2022Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2., J Exp Med 2022 Jul; 219(7): .
2022Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery., Nat Commun 2022 Jun; 13(1): 3718.
2022Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins., EMBO Rep 2022 May; (): e53600.
2022Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2., EBioMedicine 2022 Mar; 77(): 103934.
2022Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller., J Exp Med 2022 Mar; 219(3): .
2022Bat coronaviruses related to SARS-CoV-2 and infectious for human cells., Nature 2022 604, 330–336.
2022Considerable escape of SARS-CoV-2 Omicron to antibody neutralization., Nature 2022 02; 602(7898): 671-675.
2022Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies, Mishra et al., Science 375, 104–109 (2022).
2021The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses., Cell 2021 Dec; 184(25): 6052-6066.e18.
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