Laboratoire

Cellules souches et Développement

Responsable

Shahragim Tajbakhsh

CNRS UMR3738

Département de Biologie du développement & cellules souches

• Asymetric division
• Cell biology and developmental biology
• Cell cycle and division
• Cell differentiation, physiology and dynamics
• Cell genetics
• Cell migration
• Cell proliferation, apoptosis and growth
• Cell signalling and cellular interactions
• Development, developmental genetics, pattern formation and organogenesis
• Epigenetics and gene regulation
• Evolution
• General biochemistry and metabolism
• Genetics
• Genetics, Genomics
• Growth and Morphogenesis
• Molecular and Structural Biology and Chemistry
• Morphology and functional imaging of cells
• Non coding RNA
• Physiology and metabolism
• Regeneration
• Replication
• Senescence
• Stem cell biology
• Transcriptomics
• Genetic disorders
• Mitochondrial disease
• Muscular diseases
• Other diseases
• Skeletal muscle dystrophies
• Chicken
• Human
• Model systems
• Mouse
• Gene therapy, stem cell therapy, regenerative medicine

VOIR TOUSFermer

Présentation

Groupes

Group

Miria Ricchetti

Groupe: Miria Ricchetti

Membres

Shahragim Tajbakhsh

Coordinateur(trice) du Labex

Responsable

Sylvain Paisant

Technicien(ne)

Marc Tournaire

Technicien(ne)

Gilles Le Carrou

Technicien(ne)

Frédérique Deflandre

Aide technique

Brendan Evano

Post-doctorant(e)

Hiroshi Sakai

Post-doctorant(e)

Glenda Comai

Post-doctorant(e)

Kartik Soni

Post-doctorant(e)

Eglantine Heude

Post-doctorant(e)

Meryem Baghdadi

Etudiant(e) en thèse

Francesca Pala

Etudiant(e) en thèse

Barbara Gayraud-Morel

Chercheur(euse) Permanent(e)

Vania Rosas Magallanes

Chef(fe) de Projet

Benjamin Montagne

Clément Crochemore

Post-doctorant(e)

Laurent Chatre

Chercheur(euse) Permanent(e)

Haser Sutcu

Etudiant(e) en thèse

Miria Ricchetti

Chef(fe) de Groupe

Zuzanna Andrzejewska

Post-doctorant(e)

Anciens Membres

Pierre Rocheteau

Fabrice Chretien

Patricia Flamant

Swetha Gopalakrishnan

Siham Yennek

Gérard Dumas

Isabelle Le Roux

Grands Projets

LabEx Revive – Biologie régénératrice et médicine

  Objectifs du Consortium ReviveDes avancées scientifiques majeures dans la biologie des cellules souches ont ouvert la voie à des activités de recherche sur la biologie fondamentale de ces cellules et leurs applications cliniques. Le […]

Projets

DNA repair in muscle stem cells and during cell differentiation

The maintenance of genome integrity plays a key role in the regeneration potential of stem cells, which are responsible for the homeostasis and regeneration of the tissue throughout life. DNA double strand breaks (DSBs) […]

Mechanism of ageing and progeroid diseases

The mechanisms governing ageing, which is a multifactorial process, have not been resolved and constitute a fundamental open question in cell and organismal biology. Ageing is dramatically accelerated in some rare genetic disorders. Dissecting […]

ERC-2012-AdG StemDNAFate

Genetic and Epigenetic Regulation of Stem Cell FateThe objective of this research programme is to identify mouse stem cell properties and understand how they regulate cell fate choice in different contexts by modulating their […]

Characterisation of skeletal muscle stem cell properties in distinct physiological states

Stem cells are defined by their is their capacity for self-renewal and differentiation. Some adult tissues maintain a reservoir of stem cells, that generally reside within specialized microenvironments, known as stem cell niches, that […]

Regulators of embryonic and adult skeletal muscle stem/progenitor cells

We use a number of genetically modified mice to interrogate specific functions of stem/progenitor cells during the establishment of muscle and its reconstitution after injury. These include mutants for Myf5, Pax7, Myod, Tbx1, RBPJk, […]

Adult muscle regeneration, symmetric and asymmetric cell divisions

Symmetric and asymmetric divisions also play key roles during growth and regeneration. We showed previously that asymmetric template DNA strand cosegregation takes place in a subpopulation of adult muscle stem cells (7). More recently […]

Adult muscle homeostasis and stem cell quiescence, and a novel dormant cell state

Adult muscle satellite (stem) cells are quiescent during homeostasis. We showed that Notch signaling is highest in quiescent muscle satellite cells, and this activity drops dramatically before the first cell division after muscle injury […]

How stem cells generate distinct classes of progeny during ontology

During tissuegenesis, muscle stem cells generate phenotypically and functionally distinct embryonic and foetal myoblasts (1, 2). We used genetically modified mice and constitutively expressed the intracellular domain of Notch1 receptor (NICD) to block the […]

Genetic studies reveal differences between somite and cranial mesoderm derived muscles

The paired/ homeodomain genes Pax3 and Pax7, act primarily in somites to regulate stem/progenitor cells in the body whereas Tbx1 and Pitx2 play critical roles in cranial mesoderm derived muscles in the head. Subsequently, […]

Publications

• 2016
  Anti-HIV microRNA expression in a novel Indian cohort - Dey R, Soni K, Saravanan S, Balakrishnan P, Kumar V, Boobalan J, Solomon SS, Scaria V, Solomon S, Brahmachari SK, Pillai B - Scientific reports
• 2016
  Comparative Study of Injury Models for Studying Muscle Regeneration in Mice - Hardy D, Besnard A, Latil M, Jouvion G, Briand D, Thépenier C, Pascal Q, Guguin A, Gayraud-Morel B, Cavaillon JM, Tajbakhsh S, Rocheteau P, Chrétien F - PloS one
• 2016
  A Single-Cell Resolution Imaging Protocol of Mitochondrial DNA Dynamics in Physiopathology, mTRIP, Which Also Evaluates Sublethal Cytotoxicity - Chatre L, Montagne B, Ricchetti M - Methods in molecular biology (Clifton, N.J.)
• 2015
  Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy - Rocheteau P, Chatre L, Briand D, Mebarki M, Jouvion G, Bardon J, Crochemore C, Serrani P, Lecci PP, Latil M, Matot B, Carlier PG, Latronico N, Huchet C, Lafoux A, Sharshar T, Ricchetti M, Chrétien F - Nature communications
• 2015
  Numb is required to prevent p53-dependent senescence following skeletal muscle injury - Le Roux I, Konge J, Le Cam L, Flamant P, Tajbakhsh S - Nature communications
• 2015
  Novel MicroRNA signatures in HPV-mediated cervical carcinogenesis in Indian women - Sharma S, Hussain S, Soni K, Singhal P, Tripathi R, Ramachandran VG, Sharma S, Das S, Pillai B, Bharadwaj M - Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
• 2015
  A Cranial Mesoderm Origin for Esophagus Striated Muscles - Gopalakrishnan S, Comai G, Sambasivan R, Francou A, Kelly RG, Tajbakhsh S - Developmental cell
• 2015
  Neuropathological Correlates of Hyperglycemia During Prolonged Polymicrobial Sepsis in Mice - Sonneville R, Derese I, Marques MB, Langouche L, Derde S, Chatre L, Chrétien F, Annane D, Sharshar T, Van den Berghe G, Vanhorebeek I - Shock (Augusta, Ga.)
• 2015
  Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy - Chal J, Oginuma M, Al Tanoury Z, Gobert B, Sumara O, Hick A, Bousson F, Zidouni Y, Mursch C, Moncuquet P, Tassy O, Vincent S, Miyanari A, Bera A, Garnier JM, Guevara G, Hestin M, Kennedy L, Hayashi S, Drayton B, Cherrier T, Gayraud-Morel B, Gussoni E, Relaix F, Tajbakhsh S, Pourquié O - Nature biotechnology
• 2015
  Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation - Skalska L, Stojnic R, Li J, Fischer B, Cerda-Moya G, Sakai H, Tajbakhsh S, Russell S, Adryan B, Bray SJ - The EMBO journal
• +
  Voir la liste complète de publications

Open Positions

(EN)

We are constantly looking for motivated postdocs and PhD students. Interested candidates should send their CV and motivation letter to frederique.deflandre@pasteur.fr

Contact

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Address
25-28 Rue du Docteur Roux
75015, Paris
France