(EN) Throughout my research career I have been interested in how a better understanding of fundamental immunology can be applied to novel solutions for improving human health. I undertook a PhD in immunological memory, and with progression of my career moved closer to translational research to deliver research findings to the clinic. During my post-doctoral positions I worked on vaccine development projects for HIV and TB to understand how different vaccination strategies impact innate and adaptive immunity. I also worked on biomarker discovery and validation projects, in particular for Hepatitis C infection. As part of an FP7 project that we lead, we developed and clinically validated a novel Point of Care based test for diangosing HCV infection, that is now in clinical use worldwide. The current focus of our research with the Translational Immunology Lab, and also as co-cordinator of the LabEx Milieu Interieur project is to understand the genetic and environmental determinants of a healthy immune response, and also apply these findings to disease settings to develop new diagnostic and therapeutic approaches.
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10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
2018-12-02 09:00:00
2018-12-15 18:00:00
Europe/Paris
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
HKU-Pasteur Research Centre, Hong Kong
Projets Transversaux
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Publications
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2020Understanding immune variation for improved translational medicine., Curr. Opin. Immunol. 2020 Jul; 65(): 83-88.
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2020Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients., Science 2020 Aug7; 369(6504): 718-724.
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2020Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome., J. Clin. Immunol. 2020 Aug; 40(6): 807-819.
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2020Catatonia in a patient with Aicardi-Goutières syndrome efficiently treated with immunoadsorption., Schizophr. Res. 2020 Jun; (): .
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2020Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes., Diabetologia 2020 Aug; 63(8):1576-1587.
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2020Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients., Angiogenesis 2020 May; (): .
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2020Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort., Am. J. Clin. Nutr. 2020 May; (): .
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2020The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway, Haematologica 2020 Mar;.
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2020Antibody-coated microbiota in nasopharynx of healthy individuals and hypogammaglobulinemia patients, J. Allergy Clin. Immunol. 2020 Jun;145(6):1686-1690.
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2020Neuromyelitis optica in patients with increased interferon alpha concentrations, Lancet Neurol 2020 01;19(1):31-33.
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