10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
The Healthy Human Global Project
Le projet Milieu Intérieur est l’un des lauréats de la première vague d’appel d’offre “Laboratoire d’Excellence” lancé dans le cadre du programme de relance économique « Investissements d’avenir » du gouvernement français. Le projet […]
Milieu Intérieur [LabEx]
Qu’est-ce que le projet Milieu Intérieur ? Le projet Milieu Intérieur est l’un des lauréats de la première vague d’appel d’offre “Laboratoire d’Excellence”. Le projet Milieu Intérieur réunit l’expertise multidisciplinaire de chercheurs dans les […]
Modeling SARS-CoV-2 infection and immune responses in humanized mouse models
Deciphering the causes of Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
Immune profiling to guide host-directed interventions to cure HBV
The overall aim of the project is to investigate the immune responses to HBV and develop novel treatment concepts to cure chronic HBV. HBV is a major global health problem with over 257 million […]
Deciphering Human Innate Lymphoid Cell Biology
ILCs are early effectors of immunity and provide a means to rapidly respond to infection or inflammation, and are distinguished from T and B cells of the adaptive immune response. Three groups of ILCs […]
Genetic traits involved in the regulation of NK cell and ILC-mediated anti-tumor functions
Rudolf Virchow postulated more than 150 years ago that inflammation might be linked to cancer development. Although a large body of experimental evidence accumulated to date strongly supports such a link, it is less […]
Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]
Think tank: Mucosal Immunology
The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Mouse Model to Understand Innate Lymphoid Cell Biology
Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]
Pathogen co-infection : HIV, TB, Malaria and HCV
Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]
Host responses to microbial intestinal invasion, impact on microbial dissemination
We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
Humanized mouse models for studying viral hepatitis
Hepatitis B virus (HBV), hepatitis C virus (HCV) and Plasmodium falciparum are three major human hepatic pathogens, which together are responsible for more than 500 million infections worldwide and 2.5 to 4.5 million deaths […]
A novel mouse model for conditional gene targeting
Research in the Innate Immunity Unit strives to understand the signals that regulate lymphoid lineage development and the mechanisms that promote the functional diversification of lymphocyte responses. Modeling Hepatitis B virus infections in a […]
2021Host genetic control of natural killer cell diversity revealed in the Collaborative Cross., Proc Natl Acad Sci U S A 2021 Mar; 118(10): .
2021Polarized mitochondria as guardians of NK cell fitness., Blood Adv 2021 Jan; 5(1): 26-38.
2020Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa., 2020 Sep 24;140598..
2020Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers., J. Exp. Med. 2020 ; 217(10): .
2020Innovations, challenges, and minimal information for standardization of humanized mice., EMBO Mol Med 2020 Jun; (): e8662.
2020Microbiota stimulation generates LCMV-specific memory CD8+ T cells in SPF mice and determines their TCR repertoire during LCMV infection., Mol. Immunol. 2020 Jun; 124(): 125-141.
2020STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice., Cell Rep 2020 Jun; 31(11): 107771.
2020Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA, Immunity 2020 Apr;52(4):635-649.e4.
2020Changing guard but maintaining values, Eur. J. Immunol. 2020 Feb;50(2):155.
2020Antibody-coated microbiota in nasopharynx of healthy individuals and hypogammaglobulinemia patients, J. Allergy Clin. Immunol. 2020 Jun;145(6):1686-1690.
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