9th HKU-Pasteur Immunology Course: March 19-31, 2017
The general theme of this year’s course will be Quantitative Immunology to explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, to a more integrated view […]
Deciphering Human Innate Lymphoid Cell Biology
ILCs are early effectors of immunity and provide a means to rapidly respond to infection or inflammation, and are distinguished from T and B cells of the adaptive immune response. Three groups of ILCs […]
Genetic traits involved in the regulation of NK cell and ILC-mediated anti-tumor functions
Rudolf Virchow postulated more than 150 years ago that inflammation might be linked to cancer development. Although a large body of experimental evidence accumulated to date strongly supports such a link, it is less […]
Journée de la recherche translationnelle (JRT)
A full-day mini-symposium dedicated to translational research. This event was organised at Institut Pasteur from 2007 by the former Center for Human Immunology and is organised since 2015 by the Centre de recherche Translationnelle. […]
Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]
Adult neurogenesis and brain plasticity
The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]
Think tank: Mucosal Immunology
The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Mouse Model to Understand Innate Lymphoid Cell Biology
Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]
Pathogen co-infection : HIV, TB, Malaria and HCV
Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]
Host responses to microbial intestinal invasion, impact on microbial dissemination
We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
Humanized mouse models for studying viral hepatitis
Hepatitis B virus (HBV), hepatitis C virus (HCV) and Plasmodium falciparum are three major human hepatic pathogens, which together are responsible for more than 500 million infections worldwide and 2.5 to 4.5 million deaths […]
A novel mouse model for conditional gene targeting
Research in the Innate Immunity Unit strives to understand the signals that regulate lymphoid lineage development and the mechanisms that promote the functional diversification of lymphocyte responses. Modeling Hepatitis B virus infections in a […]
2017Humanized mouse models to study pathophysiology and treatment of HIV infection, Curr Opin HIV AIDS 2017 Nov;.
2017Regulatory T cells control toxicity in a humanized model of IL-2 therapy, Nat Commun 2017 Nov;8(1):1762.
2017Guidelines for the use of flow cytometry and cell sorting in immunological studies, Eur. J. Immunol. 2017 Oct;47(10):1584-1797.
2017Lactobacillus paracasei feeding improves immune control of influenza infection in mice, PLoS ONE 2017;12(9):e0184976.
2017‘ILC-poiesis’: generating tissue ILCs from naïve precursors, Oncotarget 2017 Oct;8(47):81729-81730.
2017Viral load affects the immune response to HBV in mice with humanized immune system and liver, Gastroenterology 2017 Aug;153(6):1647-1661.e9.
2017Animal models for viral diseases: Non-human primate and humanized mouse models for viral infections, Curr Opin Virol 2017 Aug;25:v-vii.
2017Synergy between the Host Immune System and Bacteriophage Is Essential for Successful Phage Therapy against an Acute Respiratory Pathogen, Cell Host Microbe 2017 Jul;22(1):38-47.
2017Modeling Natural Killer Cell Targeted Immunotherapies, Front Immunol 2017;8:370.
2017Developmental options and functional plasticity of innate lymphoid cells, Curr. Opin. Immunol. 2017 Mar;44:61-68.
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