Timeline

Darragh Duffy
Labex Coordinator
01 Sep 2021
publication

Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection.

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18 Aug 2021
news

Immune checkpoint inhibitors improve cellular immunity against SARS-CoV-2 infection

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01 Aug 2021
publication

Differential levels of IFNα subtypes in autoimmunity and viral infection.

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01 Aug 2021
publication

Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection.

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19 Jul 2021
publication

Kinetics of the SARS-CoV-2 antibody response and serological estimation of time since infection.

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17 Jul 2021
publication

Platelet activation in critically ill COVID-19 patients.

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16 Jul 2021
publication

SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance.

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04 Jun 2021
publication

Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients.

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17 May 2021
publication

Diversity in immunogenomics: the value and the challenge.

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05 May 2021
publication

Ultrasensitive detection of p24 in plasma samples from people with primary and chronic HIV-1 infection.

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01 May 2021
publication

HIV DNA reservoir and elevated PD-1 expression of CD4 T-cell subsets particularly persist in the terminal ileum of HIV-positive patients despite cART.

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01 Apr 2021
publication

Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies.

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03 Mar 2021
event

The ageing immune system: implications for disease susceptibility

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12 Feb 2021
publication

JAK inhibitors are effective in a subset of patients with juvenile dermatomyositis: a monocentric retrospective study.

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01 Feb 2021
publication

Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients.

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04 Jan 2021
publication

TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons.

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04 Jan 2021
publication

Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers.

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01 Jan 2021
publication

Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols.

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01 Jan 2021
publication

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment.

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17 Dec 2020
project

Deciphering the causes of Hidradenitis Suppurativa

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10 Dec 2020
publication

Associations between untargeted plasma metabolomic signatures and gut microbiota composition in the Milieu Intérieur population of healthy adults.

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02 Dec 2020
publication

Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo.

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26 Nov 2020
publication

JAK Inhibition in the Aicardi-Goutières Syndrome.

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02 Nov 2020
publication

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling.

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16 Oct 2020
publication

Immune profiling enables stratification of patients with active TB disease or M. tuberculosis infection.

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15 Oct 2020
publication

Interleukin-7/Interferon axis drives T-cell and salivary gland epithelial cell interactions in Sjögren’s syndrome.

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08 Oct 2020
news

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

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29 Sep 2020
news

Detection of autoantibodies against type I IFNs in patients as a cause of life-threatening COVID-19

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24 Sep 2020
publication

Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa.

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24 Sep 2020
publication

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

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24 Sep 2020
publication

Autoantibodies against type I IFNs in patients with life-threatening COVID-19.

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19 Sep 2020
publication

Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus.

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28 Aug 2020
event

PhD thesis defence Celine Posseme “Study of natural immune variability to dissect cytokine response pathways”

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31 Jul 2020
publication

Understanding immune variation for improved translational medicine.

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29 Jul 2020
event

Milieu Intérieur Annual Meeting 2020

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13 Jul 2020
publication

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.

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02 Jul 2020
team

Translational Immunology

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26 Jun 2020
news

Curie-O-SA : étude de la réponse immunitaire contre le virus SARS-CoV2

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22 Jun 2020
publication

Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome.

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19 Jun 2020
publication

Catatonia in a patient with Aicardi-Goutières syndrome efficiently treated with immunoadsorption.

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05 Jun 2020
publication

Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes.

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27 May 2020
publication

Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients.

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05 May 2020
publication

Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort.

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10 Apr 2020
team

Group : Milieu Intérieur

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05 Mar 2020
publication

The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway

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16 Jan 2020
publication

Antibody-coated microbiota in nasopharynx of healthy individuals and hypogammaglobulinemia patients

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01 Jan 2020
publication

Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue.

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01 Jan 2020
publication

Neuromyelitis optica in patients with increased interferon alpha concentrations

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01 Jan 2020
publication

Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults.

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13 Dec 2019
publication

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in

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26 Nov 2019
publication

PSMB10, the last immunoproteasome gene missing for PRAAS

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26 Nov 2019
publication

Cardiac valve involvement in -related type I interferonopathy

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22 Nov 2019
publication

Anti-MDA5 juvenile idiopathic inflammatory myopathy: a specific subgroup defined by differentially enhanced interferon-α signalling

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05 Nov 2019
event

Population and systems immunology symposium

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30 Oct 2019
publication

Use of ruxolitinib in COPA syndrome manifesting as life-threatening alveolar haemorrhage

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30 Oct 2019
publication

Inhibition of IFNα secretion in cells from patients with juvenile dermatomyositis under TBK1 inhibitor treatment revealed by single-molecular assay technology

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05 Oct 2019
publication

Risk factors associated with myasthenia gravis in thymoma patients: The potential role of thymic germinal centers

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05 Sep 2019
publication

Circulating interferon-α measured with a highly sensitive assay as a biomarker for juvenile inflammatory myositis activity

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22 Aug 2019
publication

Plasma Type I IFN Protein Concentrations in Human Tuberculosis

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10 Jul 2019
publication

Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment

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18 Jun 2019
publication

A Call for Blood-In Human Immunology

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14 Jun 2019
publication

Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles

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30 May 2019
publication

Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection

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22 May 2019
publication

IP-10 contributes to the inhibition of mycobacterial growth in an ex vivo whole blood assay

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16 May 2019
event

Department of Immunology seminar: Lydia Lynch, Interdependence of Systemic and Cellular Immunometabolism (Immune Cells are What you Eat)

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29 Apr 2019
publication

Novel DSP Spectrin 6 Region Variant Causes Neonatal Erythroderma, Failure to Thrive, Severe Herpes Simplex Infections and Brain Lesions

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23 Apr 2019
event

Department of Immunology seminar: Matthew Hepworth

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08 Apr 2019
publication

Delineating the healthy human skin UV response and early induction of interferon pathway in cutaneous lupus erythematosus

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01 Apr 2019
publication

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

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07 Mar 2019
publication

Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined

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18 Feb 2019
publication

Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth

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06 Dec 2018
publication

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

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01 Nov 2018
publication

A child with severe juvenile dermatomyositis treated with ruxolitinib

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12 Oct 2018
project

CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie

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03 Oct 2018
publication

Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency

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24 Sep 2018
publication

Immune response biomarkers in human and veterinary research

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22 Sep 2018
publication

Potential utility of the Genedrive point-of-care test for HCV RNA detection

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07 Sep 2018
publication

First description of agonist and antagonist IP-10 in urine of patients with active TB

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05 Sep 2018
publication

Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus.

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25 Jul 2018
publication

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

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19 Jul 2018
publication

Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project

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05 Jul 2018
publication

Interplay of DDP4 and IP-10 as a Potential Mechanism for Cell Recruitment to Tuberculosis Lesions

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01 Jul 2018
publication

Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage.

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29 Jun 2018
publication

Standardized Immunomonitoring: Separating the Signals from the Noise

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19 Jun 2018
publication

Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses

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14 Jun 2018
publication

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

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01 Jun 2018
publication

JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis

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01 Jun 2018
publication

Comment on: ‘Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors’ by Giannelou : mutations in result in a constitutive activation of type I interferon signalling

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01 May 2018
publication

Milieu intérieur: Defining the boundaries of a healthy immune response for improved vaccination strategies

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03 Apr 2018
publication

Development and clinical validation of the Genedrive point-of-care test for qualitative detection of hepatitis C virus

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22 Mar 2018
publication

T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation

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01 Mar 2018
publication

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.

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31 Dec 2017
course

10th HKU-Pasteur Immunology Course: December 2-15, 2018

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19 Dec 2017
publication

Type I interferon-mediated autoinflammation due to DNase II deficiency

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28 Nov 2017
publication

Myogenic Progenitor Cells Exhibit Type I Interferon-Driven Proangiogenic Properties and Molecular Signature During Juvenile Dermatomyositis

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21 Sep 2017
publication

Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study

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06 Sep 2017
publication

An in vitro diagnostic certified point of care single nucleotide test for IL28B polymorphisms

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31 Aug 2017
publication

Development of a bead-based multiplex assay for the analysis of the serological response against the six pathogens HAV, HBV, HCV, CMV, T. gondii and H. pylori

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13 Jul 2017
publication

Deconvolution of the Response to Bacillus Calmette-Guérin Reveals NF-κB-Induced Cytokines As Autocrine Mediators of Innate Immunity

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20 Apr 2017
publication

TBK1/IKKE blockade inhibits mutant STING mediated inflammatory response in patient cells

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18 Apr 2017
publication

Detection of interferon alpha protein reveals differential levels and cellular sources in disease

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15 Mar 2017
publication

Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents.

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20 Oct 2016
publication

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

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26 Aug 2016
news

New publication for Milieu Intérieur

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25 Aug 2016
publication

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

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24 Mar 2016
publication

Protein biomarkers discriminate Leishmania major-infected and non-infected individuals in areas endemic for cutaneous leishmaniasis

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29 Jan 2016
event

Milieu Intérieur Scientific Advisory Board

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24 Sep 2015
news

Explore the Milieu Intérieur data

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10 Sep 2015
project

Biomarker discovery and viral disease pathogenesis

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10 Sep 2015
project

Milieu Intérieur: Deconvolution of the healthy immune response

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10 Sep 2015
project

Functional immune response to Mycobacteria tuberculosis derived antigen

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04 Aug 2015
program_project

The Healthy Human Global Project

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16 Jul 2015
publication

Dynamic Changes of Post-Translationally Modified Forms of CXCL10 and Soluble DPP4 in HCV Subjects Receiving Interferon-Free Therapy

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11 Jul 2015
program_project

LabEx Milieu Intérieur

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01 Apr 2015
publication

The Milieu Intérieur study – an integrative approach for study of human immunological variance.

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07 Jan 2015
publication

Automated flow cytometric analysis across large numbers of samples and cell types

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01 Oct 2014
publication

Apolipoprotein H expression is associated with IL28B genotype and viral clearance in hepatitis C virus infection.

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20 Mar 2014
publication

Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli

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18 Feb 2014
publication

The ABCs of viral hepatitis that define biomarker signatures of acute viral hepatitis

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07 May 2013
publication

CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients

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08 Nov 2012
publication

Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8+ T cells

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04 Jan 2012
publication

Cutting edge: Protective effect of CX3CR1+ dendritic cells in a vaccinia virus pulmonary infection model

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15 Dec 2011
publication

Intradermal immunization triggers epidermal Langerhans cell mobilization required for CD8 T-cell immune responses

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09 May 2011
publication

CD56brightCD16+ NK cells: a functional intermediate stage of NK cell differentiation

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07 May 2011
publication

Targeting of HIV-p24 particle-based vaccine into differential skin layers induces distinct arms of the immune responses

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19 Mar 2010
publication

Keeping the memory of influenza viruses

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14 Dec 2009
publication

Immunological memory transferred with CD4 T cells specific for tuberculosis antigens Ag85B-TB10.4: persisting antigen enhances protection

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07 Dec 2009
publication

Original encounter with antigen determines antigen-presenting cell imprinting of the quality of the immune response in mice

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08 Apr 2009
publication

Influence of antigen exposure on the loss of long-term memory to childhood vaccines in HIV-infected patients

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04 Dec 2008
publication

Nanoparticle-based targeting of vaccine compounds to skin antigen-presenting cells by hair follicles and their transport in mice

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15 Jan 2008
publication

Transgenic CD4 T cells (DO11.10) are destroyed in MHC-compatible hosts by NK cells and CD8 T cells

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01 Nov 2006
publication

Naive T-cell receptor transgenic T cells help memory B cells produce antibody

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15 Feb 2006
publication

The phenotype and survival of antigen-stimulated transgenic CD4 T cells in vivo: the influence of persisting antigen

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01 Jan 1970
publication

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.

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01 Jan 1970
publication

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.

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