Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Service photographie
Vue sur les capillaires d'un séquenceur d'ADN de la Plate Forme Génomique.
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell Reports - 25 Aug 2016

Alejandra Urrutia, Darragh Duffy, Vincent Rouilly, Céline Posseme, Raouf Djebali, Gabriel Illanes, Valentina Libri, Benoit Albaud, David Gentien, Barbara Piasecka, Milena Hasan, Magnus Fontes, Lluis Quintana-Murcic, Matthew L. Albert, Milieu Intérieur Consortium

DOI: http://dx.doi.org/10.1016/j.celrep.2016.08.011 show

The initiation of inflammatory responses is typically triggered by a local event engaging sentinel cells, leading to the subsequent recruitment and accumulation of leukocytes. This process can result in the elimination of the initial cause of tissue disruption, the clearance of dying cells, and establishes a path toward tissue resolution. Cytokines mediate cell-to-cell communication, acting to recruit immune cells to inflammatory microenvironment and drive the required effector mechanisms. Despite the inherent complexity of these processes in natura, analyses of inflammation have typically focused on the decision-making circuits within cells, and, in most cases, have been restricted to single cell types (Amit et al., 2009, Jovanovic et al., 2015, Lee et al., 2014). Several other studies have assessed in vivo responses to vaccination, typically performing sampling over time to assess induced protein, mRNA expression, and seroconversion (Banchereau et al., 2014, Li et al., 2014, Tsang et al., 2014). While informative, these latter approaches permit the testing of only one stimulation condition per individual and are restricted to qualified or experimental vaccines. To properly account for inter-individual variability in the deconvolution of complex immune responses, both simple (synthetic or purified ligand) and complex (live or heat-killed microbe), stimulations must be performed in the same donor and at the same time, and standardized approaches for all steps from sample collection to analysis must be applied.