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© Research
Publication : Cell reports. Medicine

Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell reports. Medicine - 15 Nov 2022

Sugrue JA, Posseme C, Tan Z, Pou C, Charbit B, Bondet V, Bourke NM, Brodin P, Duffy D, O'Farrelly C,

Link to Pubmed [PMID] – 36334594

Link to DOI – S2666-3791(22)00363-910.1016/j.xcrm.2022.100804

Cell Rep Med 2022 Nov; 3(11): 100804

Natural resistance to infection is an overlooked outcome after hepatitis C virus (HCV) exposure. Between 1977 and 1979, 1,200 Rhesus D-negative Irish women were exposed to HCV-contaminated anti-D immunoglobulin. Here, we investigate why some individuals appear to resist infection despite exposure (exposed seronegative [ESN]). We screen HCV-resistant and -susceptible donors for anti-HCV adaptive immune responses using ELISpots and VirScan to profile antibodies against all know human viruses. We perform standardized ex vivo whole blood stimulation (TruCulture) assays with antiviral ligands and assess antiviral responses using NanoString transcriptomics and Luminex proteomics. We describe an enhanced TLR3-type I interferon response in ESNs compared with seropositive women. We also identify increased inflammatory cytokine production in response to polyIC in ESNs compared with seropositive women. These enhanced responses may have contributed to innate immune protection against HCV infection in our cohort.

https://pubmed.ncbi.nlm.nih.gov/36334594