Ligne de temps
Darragh Duffy
Coordinateur(trice) du Labex
01 mars 2025
publication
Autoinflammatory encephalopathy due to PTPN1 haploinsufficiency: a case series.
Lire plus01 janv. 2025
publication
Comment on: Inflammatory plasma protein levels are elevated years before sarcoidosis diagnosis: a nested case-control study in Sweden.
Lire plus01 janv. 2025
publication
Efficacy of Ruxolitinib in Severe Pediatric Intra-Alveolar Hemorrhages Unrelated to COPA Mutations.
Lire plus01 janv. 2025
publication
Ultrasensitive interferons quantification reveals different cytokine profile secretion in inflammatory myopathies and can serve as biomarkers of activity in dermatomyositis.
Lire plus12 nov. 2024
publication
Increased mortality in diffuse systemic sclerosis patients with high circulating IFNα levels.
Lire plus11 oct. 2024
19 sept. 2024
02 sept. 2024
01 sept. 2024
28 août 2024
publication
Hereditary C1q Deficiency is Associated with Type 1 Interferon-Pathway Activation and a High Risk of Central Nervous System Inflammation.
Lire plus09 juil. 2024
publication
The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies.
Lire plus07 mai 2024
publication
Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people.
Lire plus06 mai 2024
publication
Sarcoidosis immunopathogenesis – a new concept of maladaptive trained immunity
Lire plus07 mars 2024
27 févr. 2024
event
Milieu Intérieur Satellite Symposium: Human cohort studies for a better understanding of immunity
Lire plus21 févr. 2024
project
Mise au point d’une méthode d’analyse de la réponse immunitaire physiologique (VARIMMET) : 2023-030
Lire plus14 févr. 2024
01 févr. 2024
01 févr. 2024
publication
Standardized high-dimensional spectral cytometry protocol and panels for whole blood immune phenotyping in clinical and translational studies.
Lire plus30 janv. 2024
publication
VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation.
Lire plus16 janv. 2024
01 janv. 2024
01 déc. 2023
publication
Unveiling Candida albicans intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response.
Lire plus15 nov. 2023
news
New publication – Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses
Lire plus05 oct. 2023
publication
Neutralizing antibody levels as a correlate of protection against SARS-CoV-2 infection: a modeling analysis.
Lire plus09 août 2023
01 août 2023
18 juil. 2023
publication
T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations
Lire plus19 juin 2023
12 mai 2023
publication
JAK Inhibition in Aicardi-Goutières Syndrome: a Monocentric Multidisciplinary Real-World Approach Study.
Lire plus01 avr. 2023
publication
Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus.
Lire plus15 mars 2023
project
PERT-SEVERE II – Impact de l’expression bactérienne et de la réponse immunitaire dans la gravité de la coqueluche
Lire plus17 janv. 2023
publication
Inactive disease in patients with lupus is linked to autoantibodies to type I interferons that normalize blood IFNα and B cell subsets.
Lire plus02 janv. 2023
publication
Osteonecrosis in patients with juvenile dermatomyositis: is it associated with anti-MDA5 autoantibody?
Lire plus01 janv. 2023
publication
Targeting the chemokine receptor CXCR4 with histamine analog to reduce inflammation in juvenile arthritis.
Lire plus05 déc. 2022
publication
Juvenile Neuropsychiatric Systemic Lupus Erythematosus: Identification of Novel Central Neuroinflammation Biomarkers.
Lire plus25 nov. 2022
publication
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity.
Lire plus15 nov. 2022
publication
Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort.
Lire plus06 oct. 2022
15 juil. 2022
news
Étude de la réponse immunitaire chez des patients infectés par le SARS-CoV-2 – CoVarImm
Lire plus28 juin 2022
publication
Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation.
Lire plus20 juin 2022
publication
Variability of Primary Sjögren’s Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA-DQ Locus.
Lire plus09 juin 2022
publication
Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming.
Lire plus24 mai 2022
publication
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
Lire plus28 avr. 2022
publication
Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency.
Lire plus18 avr. 2022
publication
CXCR3 Expression Pattern on CD4+ T Cells and IP-10 Levels with Regard to the HIV-1 Reservoir in the Gut-Associated Lymphatic Tissue.
Lire plus31 mars 2022
publication
Activation of NLRP3 Inflammasome in the Skin of Patients with Systemic and Cutaneous Lupus Erythematosus.
Lire plus28 mars 2022
news
New publication – Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC transplanted SCID patients with IL2RG/JAK3 deficiency
Lire plus09 mars 2022
publication
Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.
Lire plus23 févr. 2022
publication
Efficacy and tolerance of corticosteroids and methotrexate in patients with juvenile dermatomyositis: a retrospective cohort study.
Lire plus01 févr. 2022
01 févr. 2022
publication
Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old.
Lire plus14 janv. 2022
publication
The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies.
Lire plus01 janv. 2022
publication
Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses.
Lire plus01 janv. 2022
publication
Changes in Systemic Regulatory T Cells, Effector T Cells, and Monocyte Populations Associated With Early-Life Stunting
Lire plus01 déc. 2021
publication
Type I interferon response and vascular alteration in chilblain-like lesions during the COVID-19 outbreak.
Lire plus01 déc. 2021
17 nov. 2021
publication
Severe COVID-19 is associated with hyperactivation of the alternative complement pathway.
Lire plus16 nov. 2021
publication
Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection.
Lire plus02 nov. 2021
publication
Immune Profiling Enables Stratification of Patients With Active Tuberculosis Disease or Mycobacterium tuberculosis Infection.
Lire plus01 nov. 2021
publication
Release of infectious virus and cytokines in nasopharyngeal swabs from individuals infected with non-alpha or alpha SARS-CoV-2 variants: an observational retrospective study.
Lire plus29 oct. 2021
publication
Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patients.
Lire plus17 sept. 2021
01 sept. 2021
publication
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection.
Lire plus23 août 2021
publication
Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection.
Lire plus19 août 2021
publication
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
Lire plus18 août 2021
01 août 2021
publication
Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection.
Lire plus01 août 2021
17 juil. 2021
16 juil. 2021
publication
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance.
Lire plus04 juin 2021
publication
Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients.
Lire plus17 mai 2021
05 mai 2021
publication
Ultrasensitive Detection of p24 in Plasma Samples from People with Primary and Chronic HIV-1 Infection.
Lire plus01 mai 2021
publication
HIV DNA reservoir and elevated PD-1 expression of CD4 T-cell subsets particularly persist in the terminal ileum of HIV-positive patients despite cART.
Lire plus01 avr. 2021
publication
Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo.
Lire plus01 avr. 2021
publication
Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies.
Lire plus03 mars 2021
12 févr. 2021
publication
JAK inhibitors are effective in a subset of patients with juvenile dermatomyositis: a monocentric retrospective study.
Lire plus01 févr. 2021
publication
Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients.
Lire plus04 janv. 2021
publication
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons.
Lire plus04 janv. 2021
publication
Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers.
Lire plus01 janv. 2021
publication
Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment.
Lire plus01 janv. 2021
publication
Machine Learning-Based Single Cell and Integrative Analysis Reveals That Baseline mDC Predisposition Correlates With Hepatitis B Vaccine Antibody Response.
Lire plus01 janv. 2021
01 janv. 2021
publication
Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols.
Lire plus10 déc. 2020
publication
Associations between untargeted plasma metabolomic signatures and gut microbiota composition in the Milieu Intérieur population of healthy adults.
Lire plus26 nov. 2020
02 nov. 2020
publication
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling.
Lire plus23 oct. 2020
publication
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Lire plus15 oct. 2020
publication
Interleukin-7/Interferon axis drives T-cell and salivary gland epithelial cell interactions in Sjögren’s syndrome.
Lire plus08 oct. 2020
news
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
Lire plus29 sept. 2020
news
Detection of autoantibodies against type I IFNs in patients as a cause of life-threatening COVID-19
Lire plus24 sept. 2020
publication
Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa.
Lire plus24 sept. 2020
publication
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
Lire plus19 sept. 2020
publication
Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus.
Lire plus28 août 2020
event
PhD thesis defence Celine Posseme “Study of natural immune variability to dissect cytokine response pathways”
Lire plus01 août 2020
29 juil. 2020
13 juil. 2020
publication
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.
Lire plus02 juil. 2020
26 juin 2020
22 juin 2020
publication
Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome.
Lire plus19 juin 2020
publication
Catatonia in a patient with Aicardi-Goutières syndrome efficiently treated with immunoadsorption.
Lire plus05 juin 2020
publication
Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes.
Lire plus01 juin 2020
publication
Antibody-coated microbiota in nasopharynx of healthy individuals and IVIg-treated patients with hypogammaglobulinemia.
Lire plus27 mai 2020
publication
Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients.
Lire plus05 mai 2020
publication
Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort.
Lire plus10 avr. 2020
05 mars 2020
publication
The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway
Lire plus01 janv. 2020
publication
Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults.
Lire plus01 janv. 2020
publication
Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue.
Lire plus01 janv. 2020
publication
Neuromyelitis optica in patients with increased interferon alpha concentrations
Lire plus13 déc. 2019
publication
Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in
Lire plus26 nov. 2019
26 nov. 2019
22 nov. 2019
publication
Anti-MDA5 juvenile idiopathic inflammatory myopathy: a specific subgroup defined by differentially enhanced interferon-α signalling
Lire plus05 nov. 2019
30 oct. 2019
publication
Use of ruxolitinib in COPA syndrome manifesting as life-threatening alveolar haemorrhage
Lire plus30 oct. 2019
publication
Inhibition of IFNα secretion in cells from patients with juvenile dermatomyositis under TBK1 inhibitor treatment revealed by single-molecular assay technology
Lire plus05 oct. 2019
publication
Risk factors associated with myasthenia gravis in thymoma patients: The potential role of thymic germinal centers
Lire plus05 sept. 2019
publication
Circulating interferon-α measured with a highly sensitive assay as a biomarker for juvenile inflammatory myositis activity
Lire plus01 sept. 2019
publication
A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.
Lire plus22 août 2019
10 juil. 2019
publication
Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment
Lire plus18 juin 2019
14 juin 2019
publication
Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles
Lire plus30 mai 2019
publication
Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection
Lire plus22 mai 2019
publication
IP-10 contributes to the inhibition of mycobacterial growth in an ex vivo whole blood assay
Lire plus16 mai 2019
event
Department of Immunology seminar: Lydia Lynch, Interdependence of Systemic and Cellular Immunometabolism (Immune Cells are What you Eat)
Lire plus01 mai 2019
publication
Associations between usual diet and gut microbiota composition: results from the Milieu Intérieur cross-sectional study.
Lire plus29 avr. 2019
publication
Novel DSP Spectrin 6 Region Variant Causes Neonatal Erythroderma, Failure to Thrive, Severe Herpes Simplex Infections and Brain Lesions
Lire plus23 avr. 2019
08 avr. 2019
publication
Delineating the healthy human skin UV response and early induction of interferon pathway in cutaneous lupus erythematosus
Lire plus01 avr. 2019
07 mars 2019
publication
Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined
Lire plus18 févr. 2019
publication
Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth
Lire plus06 déc. 2018
01 nov. 2018
12 oct. 2018
project
CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie
Lire plus03 oct. 2018
publication
Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency
Lire plus24 sept. 2018
22 sept. 2018
07 sept. 2018
publication
First description of agonist and antagonist IP-10 in urine of patients with active TB
Lire plus05 sept. 2018
publication
Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus.
Lire plus27 juil. 2018
publication
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.
Lire plus25 juil. 2018
19 juil. 2018
publication
Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project.
Lire plus05 juil. 2018
publication
Interplay of DDP4 and IP-10 as a Potential Mechanism for Cell Recruitment to Tuberculosis Lesions
Lire plus01 juil. 2018
publication
Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage.
Lire plus29 juin 2018
19 juin 2018
publication
Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses
Lire plus14 juin 2018
publication
Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Lire plus01 juin 2018
publication
JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis
Lire plus01 juin 2018
publication
Comment on: ‘Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors’ by Giannelou : mutations in result in a constitutive activation of type I interferon signalling
Lire plus01 mai 2018
publication
Milieu intérieur: Defining the boundaries of a healthy immune response for improved vaccination strategies
Lire plus03 avr. 2018
publication
Development and clinical validation of the Genedrive point-of-care test for qualitative detection of hepatitis C virus.
Lire plus22 mars 2018
publication
T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation
Lire plus01 mars 2018
publication
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.
Lire plus24 janv. 2018
publication
Parallel derivation of isogenic human primed and naive induced pluripotent stem cells.
Lire plus16 janv. 2018
publication
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.
Lire plus31 déc. 2017
19 déc. 2017
28 nov. 2017
publication
Myogenic Progenitor Cells Exhibit Type I Interferon-Driven Proangiogenic Properties and Molecular Signature During Juvenile Dermatomyositis
Lire plus21 sept. 2017
publication
Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study
Lire plus06 sept. 2017
publication
An in vitro diagnostic certified point of care single nucleotide test for IL28B polymorphisms
Lire plus31 août 2017
publication
Development of a bead-based multiplex assay for the analysis of the serological response against the six pathogens HAV, HBV, HCV, CMV, T. gondii and H. pylori
Lire plus13 juil. 2017
publication
Deconvolution of the Response to Bacillus Calmette-Guérin Reveals NF-κB-Induced Cytokines As Autocrine Mediators of Innate Immunity
Lire plus20 avr. 2017
publication
TBK1/IKKE blockade inhibits mutant STING mediated inflammatory response in patient cells
Lire plus18 avr. 2017
publication
Detection of interferon alpha protein reveals differential levels and cellular sources in disease
Lire plus15 mars 2017
publication
Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents.
Lire plus20 oct. 2016
publication
Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations
Lire plus06 sept. 2016
publication
Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses.
Lire plus26 août 2016
25 août 2016
publication
Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses
Lire plus24 mars 2016
publication
Protein biomarkers discriminate Leishmania major-infected and non-infected individuals in areas endemic for cutaneous leishmaniasis
Lire plus29 janv. 2016
24 sept. 2015
10 sept. 2015
10 sept. 2015
10 sept. 2015
04 août 2015
16 juil. 2015
publication
Dynamic Changes of Post-Translationally Modified Forms of CXCL10 and Soluble DPP4 in HCV Subjects Receiving Interferon-Free Therapy
Lire plus11 juil. 2015
01 avr. 2015
publication
Automated flow cytometric analysis across large numbers of samples and cell types.
Lire plus01 avr. 2015
publication
Semi-automated and standardized cytometric procedures for multi-panel and multi-parametric whole blood immunophenotyping.
Lire plus01 avr. 2015
publication
The Milieu Intérieur study – an integrative approach for study of human immunological variance.
Lire plus01 oct. 2014
publication
Apolipoprotein H expression is associated with IL28B genotype and viral clearance in hepatitis C virus infection.
Lire plus20 mars 2014
publication
Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.
Lire plus18 févr. 2014
publication
The ABCs of viral hepatitis that define biomarker signatures of acute viral hepatitis
Lire plus07 mai 2013
publication
CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients
Lire plus08 nov. 2012
publication
Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8+ T cells
Lire plus04 janv. 2012
publication
Cutting edge: Protective effect of CX3CR1+ dendritic cells in a vaccinia virus pulmonary infection model
Lire plus15 déc. 2011
publication
Intradermal immunization triggers epidermal Langerhans cell mobilization required for CD8 T-cell immune responses
Lire plus09 mai 2011
publication
CD56brightCD16+ NK cells: a functional intermediate stage of NK cell differentiation
Lire plus07 mai 2011
publication
Targeting of HIV-p24 particle-based vaccine into differential skin layers induces distinct arms of the immune responses
Lire plus19 mars 2010
14 déc. 2009
publication
Immunological memory transferred with CD4 T cells specific for tuberculosis antigens Ag85B-TB10.4: persisting antigen enhances protection
Lire plus07 déc. 2009
publication
Original encounter with antigen determines antigen-presenting cell imprinting of the quality of the immune response in mice
Lire plus08 avr. 2009
publication
Influence of antigen exposure on the loss of long-term memory to childhood vaccines in HIV-infected patients
Lire plus04 déc. 2008
publication
Nanoparticle-based targeting of vaccine compounds to skin antigen-presenting cells by hair follicles and their transport in mice
Lire plus15 janv. 2008
publication
Transgenic CD4 T cells (DO11.10) are destroyed in MHC-compatible hosts by NK cells and CD8 T cells
Lire plus01 nov. 2006
15 févr. 2006
publication