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  • Director of Center
  • Director of Department
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© Research
Publication : Vaccine

Influence of antigen exposure on the loss of long-term memory to childhood vaccines in HIV-infected patients

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Vaccine - 08 Apr 2009

Puissant-Lubrano B, Combadière B, Duffy D, Wincker N, Frachette MJ, Ait-Mohand H, Verrier B, Katlama C, Autran B

Link to Pubmed [PMID] – 19464537

Vaccine 2009 Jun;27(27):3576-83

The role of antigen exposure and of CD4 cell deficiency in the long-term persistence of immune memory to childhood vaccines remains uncertain, particularly during HIV infection. We analyzed in vaccinated ART-treated HIV+ patients with undetectable plasma HIV and CD4 cells >250/mm(3) the persistence of two memory cell pools: effector IFNgamma-producing and proliferative central memory T cells against two vaccines: (i) vaccinia against the eradicated smallpox virus, and (ii) BCG against Mtb, a persistent pathogen. None of the HIV+ patients had IFNgamma-effector cells against VV while the one patient with BCG-specific effector T cells had a recent history of tuberculosis. Proliferative responses were detectable but showed significantly lower frequency and intensity of VV-specific than tuberculin-specific responses, independently of the CD4 nadir. Thus, differential patterns of persistence or recovery of T cell memory pools against childhood vaccines are observed in treated HIV infection that are governed by antigen exposure.