Timeline
Félix A. Rey
Head of Structure
10 Oct 2025
24 Sep 2025
26 Aug 2025
12 Aug 2025
publication
Irreversible furin cleavage site exposure renders immature tick-borne flaviviruses fully infectious.
Read more01 Jul 2025
publication
Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection.
Read more01 Jun 2025
27 May 2025
publication
Toward a deeper understanding of dengue: novel method for quantification and isolation of envelope protein epitope-specific antibodies.
Read more01 May 2025
publication
Prolonged Zika Virus NS1 Protein Circulation in Patient Sera Impacts Clinical Outcome Before the Rise of a Specific IgM Response.
Read more06 Mar 2025
publication
On the role of VP3-PI3P interaction in birnavirus endosomal membrane targeting.
Read more19 Dec 2024
11 Oct 2024
publication
Structures of the Foamy virus fusion protein reveal an unexpected link with the F protein of paramyxo- and pneumoviruses.
Read more19 Jul 2024
publication
Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2.
Read more21 Jun 2024
publication
Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus.
Read more01 Dec 2023
02 Nov 2023
publication
SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells.
Read more18 Sep 2023
project
FURTHEST: Unraveling the Foamy Virus interactions with the host: insights into the molecular mechanisms of entry and neutralization
Read more21 Aug 2023
publication
New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex
Read more10 Jul 2023
publication
Qualitative monitoring of SARS-CoV-2 mRNA vaccination in humans using droplet microfluidics.
Read more14 Jun 2023
publication
Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody.
Read more01 Apr 2023
publication
Neutralization of zoonotic retroviruses by human antibodies: Genotype-specific epitopes within the receptor-binding domain from simian foamy virus.
Read more28 Mar 2023
publication
Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein.
Read more06 Mar 2023
publication
SARS-CoV-2-related bat virus behavior in human-relevant models sheds light on the origin of COVID-19.
Read more06 Mar 2023
publication
The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells.
Read more11 Feb 2023
02 Jan 2023
publication
Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination.
Read more15 Sep 2022
event
“Structural biology of beneficial viruses: the anatomy of a flagellotropic bacteriophage and surprises in the architecture of flaviviruses.”
Read more04 Jul 2022
publication
Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2.
Read more28 Jun 2022
publication
Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery.
Read more17 Jun 2022
news
New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2
Read more24 May 2022
publication
Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins.
Read more25 Apr 2022
publication
Adaptive MHC-E restricted tissue-resident NK cells are associated with persistent low antigen load in alveolar macrophages after SARS-CoV-2 infection.
Read more14 Apr 2022
08 Apr 2022
news
New publication – Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller
Read more16 Mar 2022
publication
Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses.
Read more07 Mar 2022
publication
Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller.
Read more01 Mar 2022
publication
Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2.
Read more01 Feb 2022
22 Jan 2022
publication
Immunization with GP1 but Not Core-like Particles Displaying Isolated Receptor-Binding Epitopes Elicits Virus-Neutralizing Antibodies against Junín Virus.
Read more07 Jan 2022
publication
Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.
Read more14 Dec 2021
publication
mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants.
Read more09 Dec 2021
publication
The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses.
Read more26 Nov 2021
publication
The Viral Class II Membrane Fusion Machinery: Divergent Evolution from an Ancestral Heterodimer.
Read more01 Oct 2021
17 Sep 2021
publication
Coronaviruses with a SARS-CoV-2-like receptor-binding domain allowing ACE2-mediated entry into human cells isolated from bats of Indochinese peninsula
Read more15 Sep 2021
01 Sep 2021
publication
Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling.
Read more01 Aug 2021
19 Jul 2021
publication
Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2.
Read more24 Jun 2021
publication
Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever.
Read more21 Jun 2021
publication
Structure-function relations of the SARS-CoV-2 spike protein and impact of mutations in the variants of concern.
Read more11 Jun 2021
news
COVID-19: sensitivity of the Indian variant (B.1.617.2) to monoclonal antibodies and sera from convalescent and vaccinated individuals
Read more04 May 2021
publication
In Vitro Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry.
Read more04 Mar 2021
09 Jan 2021
project
PTR2020-353 ZOOFOAMENV – Host pathogens interactions in humans infected with zoonotic foamy viruses
Read more01 Jan 2021
publication
Generation of plasma cells and CD27-IgD- B cells during hantavirus infection is associated with distinct pathological findings.
Read more15 Oct 2020
02 Sep 2020
publication
A comparison of four serological assays for detecting anti-SARS-CoV-2 antibodies in human serum samples from different populations.
Read more05 Jun 2020
publication
A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications.
Read more02 Jun 2020
publication
Extensive flavivirus E trimer breathing accompanies stem zippering of the post-fusion hairpin.
Read more01 Jun 2020
publication
A Molecular Determinant of West Nile Virus Secretion and Morphology as a Target for Viral Attenuation.
Read more21 Apr 2020
publication
Multimeric single-domain antibody complexes protect against bunyavirus infections.
Read more10 Apr 2020
04 Apr 2020
publication
Novel Toscana Virus Reverse Genetics System Establishes NSs as an Antagonist of Type I Interferon Responses.
Read more24 Mar 2020
publication
Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine.
Read more07 Feb 2020
31 Jan 2020
30 Jan 2020
publication
Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein.
Read more06 Dec 2019
publication
X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications.
Read more01 Oct 2019
publication
A protective Zika virus E-dimer-based subunit vaccine engineered to abrogate antibody-dependent enhancement of dengue infection.
Read more10 Jun 2019
publication
Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface.
Read more03 Jun 2019
20 Feb 2019
publication
Orthobunyavirus spike architecture and recognition by neutralizing antibodies.
Read more08 Feb 2019
01 Feb 2019
event
Virology Department : PhD Thesis Defense “Structural and functional studies on human syncytins -Insights into the molecular mechanisms of placental cell-cell fusion” with Catharina Ruigrok
Read more31 Jan 2019
publication
Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion.
Read more02 Jan 2019
publication
Species-Specific Functional Regions of the Green Alga Gamete Fusion Protein HAP2 Revealed by Structural Studies.
Read more01 Jan 2019
01 Jan 2019
publication
Common characteristics and unique features: A comparison of the fusion machinery of the alphaherpesviruses Pseudorabies virus and Herpes simplex virus.
Read more01 Nov 2018
13 Aug 2018
publication
Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes.
Read more29 Mar 2018
publication
Molecular determinants of Yellow Fever Virus pathogenicity in Syrian Golden Hamsters: one mutation away from virulence.
Read more08 Mar 2018
publication
Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines.
Read more01 Feb 2018
publication
The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design.
Read more01 Jan 2018
01 Jan 2018
publication
Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.
Read more01 Dec 2017
publication
Prevalence of Equine Hepacivirus Infections in France and Evidence for Two Viral Subtypes Circulating Worldwide.
Read more07 Nov 2017
publication
The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human αVβ3 Integrin via Steric Hindrance.
Read more03 Nov 2017
publication
A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion.
Read more01 Nov 2017
publication
Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections.
Read more23 Oct 2017
publication
Design and evaluation of the immunogenicity and efficacy of a biomimetic particulate formulation of viral antigens.
Read more17 Oct 2017
publication
Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion.
Read more01 Jun 2017
01 Jun 2017
publication
The Role of Heterotypic DENV-specific CD8+T Lymphocytes in an Immunocompetent Mouse Model of Secondary Dengue Virus Infection.
Read more23 May 2017
publication
Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope.
Read more16 May 2017
publication
Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2.
Read more23 Feb 2017
23 Feb 2017
01 Feb 2017
publication
A positive-strand RNA virus uses alternative protein-protein interactions within a viral protease/cofactor complex to switch between RNA replication and virion morphogenesis.
Read more13 Jan 2017
06 Jan 2017
event
Conférence du Conseil Scientifique : Flavivirus structural heterogeneity: implications for entry, antibody neutralisation and vaccine design
Read more01 Jan 2017
01 Jan 2017
publication
Crucial steps in the structure determination of a coronavirus spike glycoprotein using cryo-electron microscopy.
Read more10 Nov 2016
publication
Erratum: Structural basis of potent Zika-dengue virus antibody cross-neutralization.
Read more03 Nov 2016
01 Oct 2016
publication
Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc.
Read more12 Sep 2016
publication
Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy.
Read more01 Sep 2016
publication
Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus.
Read more04 Aug 2016
01 Jun 2016
publication
Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV.
Read more08 Feb 2016
publication
Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer.
Read more06 Jan 2016
publication
Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus.
Read more01 Jan 2016
publication
Functional Characterization of Glycoprotein H Chimeras Composed of Conserved Domains of the Pseudorabies Virus and Herpes Simplex Virus 1 Homologs.
Read more27 Oct 2015
23 Sep 2015
publication
Determinants Involved in Hepatitis C Virus and GB Virus B Primate Host Restriction.
Read more11 Sep 2015
05 Aug 2015
publication
A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus.
Read more03 Aug 2015
01 Aug 2015
publication
A replication defect of pseudorabies virus induced by targeted α-helix distortion in the syntaxin-like bundle of glycoprotein H (V275P) is corrected by an adjacent compensatory mutation (V271A).
Read more04 Jul 2015
04 Jul 2015
04 Jul 2015
04 Jul 2015
04 Jul 2015
04 Jul 2015
04 Jul 2015
04 Jul 2015
04 Jul 2015
04 Jul 2015
01 Jul 2015
publication
Corrigendum: A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus.
Read more11 May 2015
01 May 2015
publication
Corrigendum: A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus.
Read more02 Apr 2015
publication
Recognition determinants of broadly neutralizing human antibodies against dengue viruses.
Read more04 Feb 2015
publication
X-ray structure of the pestivirus NS3 helicase and its conformation in solution.
Read more15 Jan 2015
publication
Structure-based functional analyses of domains II and III of pseudorabies virus glycoprotein H.
Read more15 Dec 2014
publication
A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus.
Read more04 Dec 2014
03 Dec 2014
publication
Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies.
Read more01 Oct 2014
publication
Robust and low cost uniform (15)N-labeling of proteins expressed in Drosophila S2 cells and Spodoptera frugiperda Sf9 cells for NMR applications.
Read more03 Sep 2014
publication
The highly conserved proline at position 438 in pseudorabies virus gH is important for regulation of membrane fusion.
Read more10 Apr 2014
18 Oct 2013
01 Aug 2013
publication
The respiratory syncytial virus nucleoprotein-RNA complex forms a left-handed helical nucleocapsid.
Read more30 Jul 2013
publication
An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission.
Read more01 Jul 2013
publication
T helper type 2 bias and type 17 suppression in primary dengue virus infection in infants and young children.
Read more01 Jun 2013
23 May 2013
16 May 2013
publication
Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape.
Read more23 Apr 2013
01 Apr 2013
01 Apr 2013
06 Jan 2013
publication
Functional and evolutionary insight from the crystal structure of rubella virus protein E1.
Read more21 Dec 2012
11 Sep 2012
01 Aug 2012
publication
Structure-based mutational analysis of the highly conserved domain IV of glycoprotein H of pseudorabies virus.
Read more01 May 2012
publication
Crystal structure of the pestivirus envelope glycoprotein E(rns) and mechanistic analysis of its ribonuclease activity.
Read more01 Feb 2012
01 Feb 2012
publication
High-level secretion of recombinant monomeric murine and human single-chain Fv antibodies from Drosophila S2 cells.
Read more01 Feb 2012
publication
Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus.
Read more26 Jan 2012
publication
Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody.
Read more01 Jan 2012
publication
Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate.
Read more28 Nov 2011
publication
X-ray structure of the arenavirus glycoprotein GP2 in its postfusion hairpin conformation.
Read more12 Oct 2011
publication
Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death.
Read more01 Oct 2011
publication
Mapping a region of hepatitis C virus E2 that is responsible for escape from neutralizing antibodies and a core CD81-binding region that does not tolerate neutralization escape mutations.
Read more11 Aug 2011
01 Aug 2011
publication
Virus/host interactions: a strong force driving the diversification of cellular organisms.
Read more25 Apr 2011
publication
Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein.
Read more01 Apr 2011
01 Feb 2011
publication
Identification of new functional regions in hepatitis C virus envelope glycoprotein E2.
Read more05 Jan 2011
publication
Capsid protein identification and analysis of mature Triatoma virus (TrV) virions and naturally occurring empty particles.
Read more28 Dec 2010
publication
Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody.
Read more09 Dec 2010
01 Dec 2010
publication
Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography.
Read more22 Oct 2010
publication
Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis.
Read more16 Sep 2010
publication
The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity.
Read more01 Apr 2010
publication
Efficient method for production of high yields of Fab fragments in Drosophila S2 cells.
Read more19 Feb 2010
publication
The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule.
Read more01 Feb 2010
publication
Crystal structure of an Aquabirnavirus particle: insights into antigenic diversity and virulence determinism.
Read more27 Nov 2009
publication
Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus.
Read more01 Aug 2009
publication
[The crystal structure of the picobirnavirus capsid reveals an organization with a unique geometry].
Read more24 Jun 2009
30 Apr 2009
publication
The picobirnavirus crystal structure provides functional insights into virion assembly and cell entry.
Read more01 Apr 2009
14 Nov 2008
publication
Residues in the HIV-1 capsid assembly inhibitor binding site are essential for maintaining the assembly-competent quaternary structure of the capsid protein.
Read more01 Oct 2008
publication
Dermal-type macrophages expressing CD209/DC-SIGN show inherent resistance to dengue virus growth.
Read more25 May 2008
publication
Phasing of the Triatoma virus diffraction data using a cryo-electron microscopy reconstruction.
Read more01 Dec 2007
publication
Molecular and structural bases for the antigenicity of VP2 of infectious bursal disease virus.
Read more01 Jun 2007
18 May 2007
publication
Crystal structure of a human autoimmune complex between IgM rheumatoid factor RF61 and IgG1 Fc reveals a novel epitope and evidence for affinity maturation.
Read more01 Mar 2007
09 Feb 2007
publication
Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G.
Read more01 Feb 2007
01 Jan 2007
publication
The nine C-terminal amino acids of the respiratory syncytial virus protein P are necessary and sufficient for binding to ribonucleoprotein complexes in which six ribonucleotides are contacted per N protein protomer.
Read more01 Oct 2006
14 Jul 2006
publication
Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G.
Read more23 May 2006
publication
Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak.
Read more01 Jan 2006
01 Jan 2006
publication
Structure and interactions at the viral surface of the envelope protein E1 of Semliki Forest virus.
Read more07 Oct 2005
publication
Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates.
Read more01 Aug 2005
publication
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor.
Read more24 Jun 2005
publication
Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signals.
Read more10 May 2005
publication
Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein.
Read more25 Mar 2005
publication
The birnavirus crystal structure reveals structural relationships among icosahedral viruses.
Read more01 Sep 2004
publication
Purification, crystallization and preliminary X-ray analysis of Triatoma virus (TrV) from Triatoma infestans.
Read more01 Apr 2004
publication
Purification and crystallization reveal two types of interactions of the fusion protein homotrimer of Semliki Forest virus.
Read more01 Mar 2004
publication
Characterization of a membrane-associated trimeric low-pH-induced Form of the class II viral fusion protein E from tick-borne encephalitis virus and its crystallization.
Read more25 Feb 2004
publication
Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation.
Read more22 Jan 2004
publication
Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus.
Read more01 Jan 2004
05 Sep 2003
publication
Visualization of the target-membrane-inserted fusion protein of Semliki Forest virus by combined electron microscopy and crystallography.
Read more10 Jun 2003
publication
Dengue virus envelope glycoprotein structure: new insight into its interactions during viral entry.
Read more01 Dec 2002
publication
Genome analysis of dengue type-1 virus isolated between 1990 and 2001 in Brazil reveals a remarkable conservation of the structural proteins but amino acid differences in the non-structural proteins.
Read more01 Oct 2002
publication
On the fitting of model electron densities into EM reconstructions: a reciprocal-space formulation.
Read more01 Oct 2002
01 Apr 2002
publication
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides.
Read more06 Apr 2001
publication
The Fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH.
Read more02 Apr 2001
publication
Atomic structure of the major capsid protein of rotavirus: implications for the architecture of the virion.
Read more02 Apr 2001
01 Mar 2001
publication
Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus.
Read more01 Sep 2000
publication
Determinants in the envelope E protein and viral RNA helicase NS3 that influence the induction of apoptosis in response to infection with dengue type 1 virus.
Read more09 Nov 1999
01 Jul 1999
publication
Dengue virus type 1 nonstructural glycoprotein NS1 is secreted from mammalian cells as a soluble hexamer in a glycosylation-dependent fashion.
Read more10 May 1999
publication
The isolation of the ectodomain of the alphavirus E1 protein as a soluble hemagglutinin and its crystallization.
Read more01 Sep 1998
01 Mar 1996
publication
Comparison of two different DNA-binding modes of the NF-kappa B p50 homodimer.
Read more25 May 1995
publication
The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution.
Read more26 Jan 1995
23 Jun 1992
publication
Protein engineering of xylose (glucose) isomerase from Actinoplanes missouriensis. 1. Crystallography and site-directed mutagenesis of metal binding sites.
Read more01 Oct 1991
publication
The flavivirus envelope protein E: isolation of a soluble form from tick-borne encephalitis virus and its crystallization.
Read more01 Jan 1988
publication
Structural analysis of the 2.8 A model of Xylose isomerase from Actinoplanes missouriensis.
Read more01 Feb 1984