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  • Veterinary
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  • Deputy Director of Center
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  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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© Research
Publication : Current opinion in virology

The surface glycoproteins of hantaviruses.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in virology - 01 Oct 2021

Guardado-Calvo P, Rey FA,

Link to Pubmed [PMID] – 34418649

Link to DOI – 10.1016/j.coviro.2021.07.009S1879-6257(21)00086-9

Curr Opin Virol 2021 Oct; 50(): 87-94

Hantaviruses are rodent-borne viruses distributed worldwide, transmitted through the air and with the ability to spread from person to person. They maintain a non-symptomatic persistent infection in their rodent hosts, but their spillover to humans produces a renal or pulmonary syndrome associated with high fatality rates. Hantavirus particles are lipid-enveloped and display a characteristic surface lattice built up of tetragonal spikes composed of two glycoproteins, Gn and Gc. The pleomorphism of these particles has hindered cryo-EM efforts to obtain detailed structural information and only by using a combination of X-ray crystallography and cryo-electron tomography it was possible to build an atomic model of the surface lattice. Here we review these structural efforts and the unanticipated evolutionary relations between hantaviruses and alphaviruses highlighted by these studies.

https://pubmed.ncbi.nlm.nih.gov/34418649