Timeline

Daniel Ladant
Head of Structure
23 Jul 2019
project

Detection and countermeasures against bacterial toxins

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21 Jun 2019
publication

Post-translational acylation controls the folding and functions of the CyaA RTX toxin

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13 Nov 2018
event

25th Meeting (RT25) of the French Society of Toxinology (SFET) : “Toxins and Health: from Molecules to Organisms”.

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05 Sep 2018
event

Host cell chaperones during toxin translocation in cells

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05 Sep 2018
event

Streptococcus pneumoniae: Development of protein-based vaccines and characterization of immune responses in animal models with high susceptibility to infection

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20 Jul 2018
publication

Bioengineering of Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy

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01 May 2018
publication

Compartmentalized Cyclic AMP Production by the and Adenylate Cyclase Toxins Differentially Affects the Immune Synapse in T Lymphocytes

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01 Jan 2018
publication

A Bacterial Adenylate Cyclase-Based Two-Hybrid System Compatible with Gateway Cloning

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16 Dec 2017
publication

ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview

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07 Dec 2017
publication

Lack of MHC class II molecules favors CD8 T-cell infiltration into tumors associated with an increased control of tumor growth

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06 Apr 2017
event

ETOX18 – European Workshop on Bacterial Protein Toxins

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03 Apr 2017
publication

Analysis of Membrane Protein Interactions with a Bacterial Adenylate Cyclase-Based Two-Hybrid (BACTH) Technique

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10 Feb 2017
publication

Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis

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01 Jan 2017
publication

Protein-Protein Interaction: Bacterial Two-Hybrid

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01 Jan 2017
publication

Defining Membrane Protein Topology Using pho-lac Reporter Fusions

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05 Dec 2016
publication

Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins

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20 Nov 2015
project

Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA

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18 Nov 2015
project

Molecular crowding

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16 Sep 2015
publication

Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion

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15 Sep 2015
project

Clinical development of cancer vaccines

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23 Aug 2015
publication

Structure and function of RTX toxins.

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17 Aug 2015
project

CyaA secretion, folding and translocation across membrane

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08 Jul 2015
project

Regulatory roles of signaling Nucleotides

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08 Jul 2015
project

In vivo analysis of protein-protein interactions

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08 Jul 2015
project

Recombinant CyaA toxin as an innovative vaccine vehicle

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03 Jul 2015
project

Structure-function studies of the CyaA toxin

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29 Jun 2015
publication

Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication

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11 May 2015
team

Biochemistry of Macromolecular Interactions

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11 Feb 2015
publication

Characterization of interactions between inclusion membrane proteins from Chlamydia trachomatis

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31 Dec 2014
publication

Disorder-to-order transition in the CyaA toxin RTX domain: implications for toxin secretion

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17 Sep 2014
publication

Calcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic form

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14 Jul 2014
publication

Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses

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24 Jun 2014
publication

ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation

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06 Jun 2014
publication

Analysis of MreB interactors in Chlamydia reveals a RodZ homolog but fails to detect an interaction with MraY

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25 Nov 2013
publication

A Gateway(®) -compatible bacterial adenylate cyclase-based two-hybrid system

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24 Sep 2013
publication

Characterization of a membrane-active peptide from the Bordetella pertussis CyaA toxin

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31 Jul 2013
publication

Molecular crowding stabilizes both the intrinsically disordered calcium-free state and the folded calcium-bound state of a repeat in toxin (RTX) protein

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10 Aug 2012
publication

The β-lactam resistance protein Blr, a small membrane polypeptide, is a component of the Escherichia coli cell division machinery

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07 Jun 2012
publication

Chlamydia co-opts the rod shape-determining proteins MreB and Pbp2 for cell division

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15 Apr 2012
publication

3′-5′ phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo

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12 Jan 2012
publication

Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin

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01 Jan 2012
publication

Mean net charge of intrinsically disordered proteins: experimental determination of protein valence by electrophoretic mobility measurements

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01 Jan 2012
publication

Estimation of intrinsically disordered protein shape and time-averaged apparent hydration in native conditions by a combination of hydrodynamic methods

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22 Jul 2011
publication

Role of leucine zipper motifs in association of the Escherichia coli cell division proteins FtsL and FtsB

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15 Mar 2011
publication

Calcium-induced folding of intrinsically disordered repeat-in-toxin (RTX) motifs via changes of protein charges and oligomerization states

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01 Dec 2010
publication

Calcium-induced folding and stabilization of the intrinsically disordered RTX domain of the CyaA toxin

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20 Aug 2010
publication

Induction of anti-Tat neutralizing antibodies by the CyaA vector targeting dendritic cells: influence of the insertion site and of the delivery of multicopies of the dominant Tat B-cell epitope

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07 Jun 2010
publication

Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor

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22 Jan 2010
publication

Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the bordetella pertussis adenylate cyclase toxin

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19 Jan 2010
publication

Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin

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17 Nov 2008
publication

RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion

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31 Oct 2008
publication

Characterization of YmgF, a 72-residue inner membrane protein that associates with the Escherichia coli cell division machinery

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15 Sep 2007
publication

Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system

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20 Apr 2006
publication

Structural and functional characterization of an essential RTX subdomain of Bordetella pertussis adenylate cyclase toxin

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01 Apr 2006
publication

An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis

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21 Feb 2006
publication

Delivery of the HIV-1 Tat protein to dendritic cells by the CyaA vector induces specific Th1 responses and high affinity neutralizing antibodies in non human primates

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01 Aug 2005
publication

Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclase of Bordetella pertussis

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01 Apr 2005
publication

Interaction network among Escherichia coli membrane proteins involved in cell division as revealed by bacterial two-hybrid analysis

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15 Jan 2005
publication

Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein

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16 Dec 2004
publication

Bordetella pertussis adenylate cyclase delivers chemically coupled CD8+ T-cell epitopes to dendritic cells and elicits CTL in vivo

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01 Mar 2004
publication

Relief of catabolite repression in a cAMP-independent catabolite gene activator mutant of Escherichia coli

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01 Dec 2003
publication

Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes

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01 Sep 2003
publication

In vitro selection for enzymatic activity: a model study using adenylate cyclase

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01 Aug 2003
publication

Human immunodeficiency virus (HIV) type 1 transframe protein can restore activity to a dimerization-deficient HIV protease variant

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28 Jul 2003
publication

Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain

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01 May 2003
publication

Efficient display of two enzymes on filamentous phage using an improved signal sequence

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01 Nov 2002
publication

In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells

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01 Jun 2002
publication

Two-hybrid systems and their usage in infection biology

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