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© Sandrine Etienne-Manneville
Photo prise à l'avant (dans la protrusion) d'astrocytes primaires de rat en migration. Marquage par immunofluorescence montrant en rouge, p150 Glued, une protéine associée aux extrémités 'plus' des microtubules et en vert la tubuline des microtubules. La photographie montre l'accumulation de p150 Glued à l'avant des cellules en migration, où la protéine pourrait participer à l'ancrage des microtubules à la membrane plasmique. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaires.
Event

Streptococcus pneumoniae: Development of protein-based vaccines and characterization of immune responses in animal models with high susceptibility to infection

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
13
Sep 2018
Time
14:00:00
Institut Pasteur, Paris, France
Address
Building: Lwoff Room: 14
Location
2018-09-13 14:00:00 2018-09-13 15:00:00 Europe/Paris Streptococcus pneumoniae: Development of protein-based vaccines and characterization of immune responses in animal models with high susceptibility to infection Streptococcus pneumoniae (pneumococcus) is the main cause of respiratory infections, leading to the death of 400.000 children under the age of 5, per year, worldwide. More than 90 pneumococcal serotypes, with differences in capsular polysaccharides […] Institut Pasteur, Paris, France Daniel Ladant daniel.ladant@pasteur.fr

Speakers

Maria Leonor Sarno de Oliveira
(Bacteriology Laboratory – Instituto Butantan, São Paulo, Brazil)

About

Streptococcus pneumoniae (pneumococcus) is the main cause of respiratory infections, leading to the death of 400.000 children under the age of 5, per year, worldwide. More than 90 pneumococcal serotypes, with differences in capsular polysaccharides (PS), were described to date. Available vaccines are composed of PS from prevalent serotypes and protect against invasive disease caused by them. However, an increase in disease caused by serotypes not included in these vaccines has been observed in several countries. Our group is studying the development of protein-based vaccines as alternatives for broad-coverage protection. Particularly, formulations composed by the Pneumococcal Surface Protein A (PspA) are being tested in animal models. In addition, innate and adaptive immune responses in mice that display high susceptibility to pneumococcal infection are being characterized.

Location

Building: Lwoff
Room: 14
Address: Institut Pasteur, Paris, France