Ligne de temps
Daniel Ladant
Responsable de Structure
07 févr. 2024
20 nov. 2023
publication
B2LiVe, a label-free 1D-NMR method to quantify the binding of amphitropic peptides or proteins to membrane vesicles.
Lire plus25 sept. 2023
publication
Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin
Lire plus19 juil. 2023
23 juin 2023
publication
Immune responses and protection against Streptococcus pneumoniae elicited by recombinant Bordetella pertussis adenylate cyclase (CyaA) carrying fragments of pneumococcal surface protein A, PspA.
Lire plus25 mai 2023
10 févr. 2023
07 févr. 2023
publication
Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli.
Lire plus08 oct. 2022
publication
A Robust and Sensitive Spectrophotometric Assay for the Enzymatic Activity of Bacterial Adenylate Cyclase Toxins.
Lire plus08 sept. 2022
09 août 2022
publication
Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.
Lire plus01 mai 2021
publication
A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
Lire plus22 janv. 2021
publication
Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes.
Lire plus23 juil. 2019
21 juin 2019
publication
Post-translational acylation controls the folding and functions of the CyaA RTX toxin.
Lire plus01 mars 2019
13 févr. 2019
13 févr. 2019
publication
The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro.
Lire plus13 nov. 2018
event
25th Meeting (RT25) of the French Society of Toxinology (SFET) : “Toxins and Health: from Molecules to Organisms”.
Lire plus12 nov. 2018
publication
Differential regulation of actin-activated nucleotidyl cyclase virulence factors by filamentous and globular actin
Lire plus30 oct. 2018
publication
The extreme C terminus of the effector ExoY is crucial for binding to its eukaryotic activator, F-actin
Lire plus05 sept. 2018
05 sept. 2018
event
Streptococcus pneumoniae: Development of protein-based vaccines and characterization of immune responses in animal models with high susceptibility to infection
Lire plus20 juil. 2018
publication
Bioengineering of Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy
Lire plus01 mai 2018
publication
Compartmentalized Cyclic AMP Production by the and Adenylate Cyclase Toxins Differentially Affects the Immune Synapse in T Lymphocytes
Lire plus01 janv. 2018
publication
A Bacterial Adenylate Cyclase-Based Two-Hybrid System Compatible with Gateway Cloning
Lire plus16 déc. 2017
publication
ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview
Lire plus07 déc. 2017
publication
Lack of MHC class II molecules favors CD8 T-cell infiltration into tumors associated with an increased control of tumor growth
Lire plus06 avr. 2017
03 avr. 2017
publication
Analysis of Membrane Protein Interactions with a Bacterial Adenylate Cyclase-Based Two-Hybrid (BACTH) Technique
Lire plus10 févr. 2017
publication
Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis
Lire plus01 janv. 2017
01 janv. 2017
05 déc. 2016
publication
Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins
Lire plus20 nov. 2015
project
Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA
Lire plus18 nov. 2015
16 sept. 2015
publication
Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion.
Lire plus15 sept. 2015
23 août 2015
17 août 2015
08 juil. 2015
08 juil. 2015
08 juil. 2015
03 juil. 2015
29 juin 2015
publication
Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication
Lire plus11 mai 2015
11 févr. 2015
publication
Characterization of interactions between inclusion membrane proteins from Chlamydia trachomatis
Lire plus31 déc. 2014
publication
Disorder-to-order transition in the CyaA toxin RTX domain: implications for toxin secretion
Lire plus17 sept. 2014
publication
Calcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic form
Lire plus14 juil. 2014
publication
Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses
Lire plus24 juin 2014
publication
ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation
Lire plus06 juin 2014
publication
Analysis of MreB interactors in Chlamydia reveals a RodZ homolog but fails to detect an interaction with MraY
Lire plus25 nov. 2013
24 sept. 2013
publication
Characterization of a membrane-active peptide from the Bordetella pertussis CyaA toxin
Lire plus31 juil. 2013
publication
Molecular crowding stabilizes both the intrinsically disordered calcium-free state and the folded calcium-bound state of a repeat in toxin (RTX) protein
Lire plus10 août 2012
publication
The β-lactam resistance protein Blr, a small membrane polypeptide, is a component of the Escherichia coli cell division machinery
Lire plus07 juin 2012
publication
Chlamydia co-opts the rod shape-determining proteins MreB and Pbp2 for cell division
Lire plus15 avr. 2012
publication
3′-5′ phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo
Lire plus12 janv. 2012
publication
Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin
Lire plus01 janv. 2012
publication
Mean net charge of intrinsically disordered proteins: experimental determination of protein valence by electrophoretic mobility measurements
Lire plus01 janv. 2012
publication
Estimation of intrinsically disordered protein shape and time-averaged apparent hydration in native conditions by a combination of hydrodynamic methods
Lire plus22 juil. 2011
publication
Role of leucine zipper motifs in association of the Escherichia coli cell division proteins FtsL and FtsB
Lire plus15 mars 2011
publication
Calcium-induced folding of intrinsically disordered repeat-in-toxin (RTX) motifs via changes of protein charges and oligomerization states
Lire plus01 déc. 2010
publication
Calcium-induced folding and stabilization of the intrinsically disordered RTX domain of the CyaA toxin
Lire plus20 août 2010
publication
Induction of anti-Tat neutralizing antibodies by the CyaA vector targeting dendritic cells: influence of the insertion site and of the delivery of multicopies of the dominant Tat B-cell epitope
Lire plus07 juin 2010
publication
Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor
Lire plus22 janv. 2010
publication
Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the bordetella pertussis adenylate cyclase toxin
Lire plus19 janv. 2010
publication
Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin
Lire plus17 nov. 2008
publication
RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion
Lire plus31 oct. 2008
publication
Characterization of YmgF, a 72-residue inner membrane protein that associates with the Escherichia coli cell division machinery
Lire plus15 sept. 2007
publication
Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system
Lire plus20 avr. 2006
publication
Structural and functional characterization of an essential RTX subdomain of Bordetella pertussis adenylate cyclase toxin
Lire plus01 avr. 2006
publication
An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis
Lire plus21 févr. 2006
publication
Delivery of the HIV-1 Tat protein to dendritic cells by the CyaA vector induces specific Th1 responses and high affinity neutralizing antibodies in non human primates
Lire plus01 août 2005
publication
Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclase of Bordetella pertussis
Lire plus01 avr. 2005
publication
Interaction network among Escherichia coli membrane proteins involved in cell division as revealed by bacterial two-hybrid analysis
Lire plus15 janv. 2005
publication
Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein
Lire plus16 déc. 2004
publication
Bordetella pertussis adenylate cyclase delivers chemically coupled CD8+ T-cell epitopes to dendritic cells and elicits CTL in vivo
Lire plus01 mars 2004
publication
Relief of catabolite repression in a cAMP-independent catabolite gene activator mutant of Escherichia coli
Lire plus01 déc. 2003
publication
Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes
Lire plus01 sept. 2003
publication
In vitro selection for enzymatic activity: a model study using adenylate cyclase
Lire plus01 août 2003
publication
Human immunodeficiency virus (HIV) type 1 transframe protein can restore activity to a dimerization-deficient HIV protease variant
Lire plus28 juil. 2003
publication
Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain
Lire plus01 mai 2003
publication
Efficient display of two enzymes on filamentous phage using an improved signal sequence
Lire plus01 nov. 2002
publication
In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells.
Lire plus01 juin 2002
01 janv. 2000
publication
Bordetella pertussis adenylate cyclase toxin: a vehicle to deliver CD8-positive T-cell epitopes into antigen-presenting cells.
Lire plus15 févr. 1999
publication