Timeline

Ivo Gomperts Boneca
Head of Structure
04 Sep 2019
project

Proof of concept of the impact of gut microbiota in the clinical outcome of ICB in mouse models of cancer

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20 May 2019
publication

Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection

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22 Nov 2018
event

Department of Microbiology – Thesis Defense “Dissecting peptidoglycan trafficking and transport(ers) in Human cells” by Christiane Brenner

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22 Nov 2018
event

Department of Microbiology: «How bacteriophages protect themselves from CRISPR» by Joe Bondy Denomy

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28 Sep 2018
publication

-Deacetylases required for muramic-δ-lactam production are involved in sporulation, germination, and heat resistance

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22 Sep 2018
project

Role of nutrition and the microenvironment in cancer development

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26 Feb 2018
publication

A step-by-step guide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase

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17 Jan 2018
event

LUCA and the universal tree of life: an update

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06 Dec 2017
publication

LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition

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03 Oct 2017
publication

Molecular architecture of the PBP2-MreC core bacterial cell wall synthesis complex

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20 Sep 2017
publication

Lactobacillus paracasei feeding improves immune control of influenza infection in mice

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30 Aug 2017
publication

Nitrosative stress defences of the enterohepatic pathogenic bacterium Helicobacter pullorum

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29 May 2017
event

Department of Microbiology – Seminar by Jason Paxman, University of Melbourne (Australia)

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29 May 2017
event

“Analyse métabolomique : enjeux technologiques et applications biomédicales” by Christophe JUNOT – MICROBIOLOGY DEPARTMENT SEMINAR

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19 May 2017
publication

Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2 signaling

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05 Apr 2017
publication

Unusual α-Carbon Hydroxylation of Proline Promotes Active-Site Maturation

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22 Feb 2017
publication

Bulgecin A: The Key to a Broad-Spectrum Inhibitor  That Targets Lytic Transglycosylases

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02 Jan 2017
project

Inhibition of peptidoglycan assembly complexes

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04 Oct 2016
publication

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

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25 Aug 2016
publication

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

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29 Jul 2016
publication

Fine-Tuning Cancer Immunotherapy: Optimizing the Gut Microbiome

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22 Jul 2016
publication

Role of the N-Acetylmuramoyl-l-Alanyl Amidase, AmiA, of Helicobacter pylori in Peptidoglycan Metabolism, Daughter Cell Separation, and Virulence

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08 Jul 2016
project

Adult neurogenesis and brain plasticity

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29 Jun 2016
publication

The 4(th) Great Wall Symposium, 2015

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21 Jun 2016
publication

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

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03 Jun 2016
project

Think tank: Mucosal Immunology

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18 Feb 2016
publication

Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota

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05 Nov 2015
publication

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

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05 Oct 2015
news

Sofia Pombo new PhD student in the BGPB Unit

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18 Sep 2015
publication

Paenibacillus faecis sp. nov., isolated from human faeces

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14 Sep 2015
project

ERC-2007-Stg-202283-PGNfromSHAPEtoVIR

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17 Jul 2015
project

When Gut Bacteria Changes Brain Functions

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17 Jul 2015
tool

Optogenetic

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10 Jul 2015
publication

Common Cell Shape Evolution of Two Nasopharyngeal Pathogens

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09 Jul 2015
publication

The microbiota regulates type 2 immunity through RORγt⁺ T cells

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02 Jul 2015
project

Biology and Genetics of Bacterial Cell Wall

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01 Jul 2015
project

Symbiotic microbiota and the development and regulation of the immune system

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11 May 2015
team

Biology and Genetics of Bacterial Cell Wall

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04 Dec 2014
publication

Live imaging of bioluminescent leptospira interrogans in mice reveals renal colonization as a stealth escape from the blood defenses and antibiotics

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27 Sep 2014
publication

Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members

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01 Sep 2014
publication

FrxA is an S-nitrosoglutathione reductase enzyme that contributes to Helicobacter pylori pathogenicity

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25 Aug 2014
publication

Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes

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29 Jul 2014
publication

Harnessing the intestinal microbiome for optimal therapeutic immunomodulation

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02 Jun 2014
publication

The biology of bacterial peptidoglycans and their impact on host immunity and physiology

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01 Jun 2014
publication

The Great Wall Symposium

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16 May 2014
publication

Gut microbiome and anticancer immune response: really hot Sh*t!

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15 May 2014
publication

N-acetylglucosamine deacetylases modulate the anchoring of the gamma-glutamyl capsule to the cell wall of Bacillus anthracis

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28 Apr 2014
publication

Chemokines and antimicrobial peptides have a cag-dependent early response to Helicobacter pylori infection in primary human gastric epithelial cells

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21 Apr 2014
publication

The lacdiNAc-specific adhesin LabA mediates adhesion of Helicobacter pylori to human gastric mucosa

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17 Apr 2014
publication

The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling

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15 Apr 2014
publication

CCL17 production by dendritic cells is required for NOD1-mediated exacerbation of allergic asthma

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30 Jan 2014
publication

Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways

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17 Jan 2014
publication

Why should we need the gut microbiota to respond to cancer therapies?

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19 Dec 2013
publication

Draft Genome Sequence of Strain X47-2AL, a Feline Helicobacter pylori Isolate

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22 Nov 2013
publication

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide

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21 Nov 2013
publication

N-glycolylated peptidoglycan contributes to the immunogenicity but not pathogenicity of Mycobacterium tuberculosis

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15 Nov 2013
publication

The dynamics of peptidoglycan structure and function: conference report on the 3rd Great Wall Symposium

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20 Sep 2013
publication

Listeria monocytogenes multidrug resistance transporters and cyclic di-AMP, which contribute to type I interferon induction, play a role in cell wall stress

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12 Jul 2013
publication

The functional vanGCd cluster of Clostridium difficile does not confer vancomycin resistance

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12 Jun 2013
publication

Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis

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05 Apr 2013
publication

Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid

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05 Apr 2013
publication

Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid.

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12 Feb 2013
publication

Inheritance of the lysozyme inhibitor Ivy was an important evolutionary step by Yersinia pestis to avoid the host innate immune response

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03 Feb 2013
publication

De-O-acetylation of peptidoglycan regulates glycan chain extension and affects in vivo survival of Neisseria meningitidis

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21 Jan 2013
publication

Distinct functions of polysaccharide deacetylases in cell shape, neutral polysaccharide synthesis and virulence of Bacillus anthracis

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06 Dec 2012
publication

Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells

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21 Sep 2012
publication

Peptidoglycan maturation enzymes affect flagellar functionality in bacteria

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16 Aug 2012
publication

Peptidoglycan sensing by the receptor PGRP-LE in the Drosophila gut induces immune responses to infectious bacteria and tolerance to microbiota

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21 Apr 2012
publication

Almost all human gastric mucin O-glycans harbor blood group A, B or H antigens and are potential binding sites for Helicobacter pylori

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20 Mar 2012
publication

The effect of bulgecin A on peptidoglycan metabolism and physiology of Helicobacter pylori

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06 Mar 2012
publication

Helicobacter pylori has an unprecedented nitric oxide detoxifying system

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08 Feb 2012
publication

Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome

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22 Dec 2011
publication

Helicobacter pylori versus the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa

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07 Nov 2011
publication

Super-resolution microscopy reveals cell wall dynamics and peptidoglycan architecture in ovococcal bacteria

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27 Oct 2011
publication

Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor 4

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08 Oct 2011
publication

Expression and functional importance of innate immune receptors by intestinal epithelial cells

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29 Sep 2011
publication

A novel metal transporter mediating manganese export (MntX) regulates the Mn to Fe intracellular ratio and Neisseria meningitidis virulence

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15 Sep 2011
publication

Characterization of the elongasome core PBP2 : MreC complex of Helicobacter pylori

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01 Sep 2011
publication

OatA, a peptidoglycan O-acetyltransferase involved in Listeria monocytogenes immune escape, is critical for virulence

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19 Jul 2011
publication

Mycolactone diffuses into the peripheral blood of Buruli ulcer patients–implications for diagnosis and disease monitoring

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06 Apr 2011
publication

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

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27 Sep 2010
publication

A M23B family metallopeptidase of Helicobacter pylori required for cell shape, pole formation and virulence

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25 Jun 2010
publication

Bacteria and MAMP-induced morphogenesis of the immune system

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10 Jun 2010
publication

From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma

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10 Jun 2010
publication

From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma.

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21 Dec 2009
publication

The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides

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08 Nov 2009
publication

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

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29 Apr 2009
publication

A commensal Helicobacter sp. of the rodent intestinal flora activates TLR2 and NOD1 responses in epithelial cells

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19 Feb 2009
publication

Mammalian PGRPs in the spotlight

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01 Feb 2008
publication

Development of inducible systems to engineer conditional mutants of essential genes of Helicobacter pylori

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07 Sep 2007
publication

New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus

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21 Jul 2007
publication

HobA–a novel protein involved in initiation of chromosomal replication in Helicobacter pylori

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08 Feb 2007
publication

Peptidoglycan detection by mammals and flies

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10 Jan 2007
publication

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system

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03 Nov 2006
publication

Characterization of Helicobacter pylori lytic transglycosylases Slt and MltD

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01 Sep 2006
publication

Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape

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24 Feb 2006
publication

Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2

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02 Sep 2005
publication

Nod1 participates in the innate immune response to Pseudomonas aeruginosa

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22 Aug 2005
publication

The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists

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16 Jun 2005
publication

Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis

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01 Feb 2005
publication

The role of peptidoglycan in pathogenesis

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15 Dec 2004
publication

Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway

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17 Oct 2004
publication

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

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26 Sep 2004
publication

Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria

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10 Sep 2004
publication

Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition

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18 Jul 2003
publication

Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2

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10 Jun 2003
publication

Detailed structural analysis of the peptidoglycan of the human pathogen Neisseria meningitidis

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10 Jun 2003
publication

Correlation between alterations of the penicillin-binding protein 2 and modifications of the peptidoglycan structure in Neisseria meningitidis with reduced susceptibility to penicillin G

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06 Jun 2003
publication

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

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01 Jun 2003
publication

Vancomycin resistance: occurrence, mechanisms and strategies to combat it

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15 Mar 2003
publication

A revised annotation and comparative analysis of Helicobacter pylori genomes

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13 Jan 2003
publication

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

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01 Nov 2002
publication

Prediction, assessment and validation of protein interaction maps in bacteria

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24 Aug 2001
publication

Selective cleavage of D-Ala-D-Lac by small molecules: re-sensitizing resistant bacteria to vancomycin

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01 Apr 2000
publication

Characterization of Staphylococcus aureus cell wall glycan strands, evidence for a new beta-N-acetylglucosaminidase activity

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14 Nov 1997
publication

Structural characterization of an abnormally cross-linked muropeptide dimer that is accumulated in the peptidoglycan of methicillin- and cefotaxime-resistant mutants of Staphylococcus aureus

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