Timeline
Ivo Gomperts Boneca
Head of Structure
18 Mar 2024
01 Feb 2024
06 Jan 2024
publication
Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake.
Read more26 Dec 2023
publication
Identification of a muropeptide precursor transporter from gut microbiota and its role in preventing intestinal inflammation.
Read more09 Dec 2023
publication
Leptospiral lipopolysaccharide dampens inflammation through upregulation of autophagy adaptor p62 and NRF2 signaling in macrophages.
Read more01 Dec 2023
publication
Activation of Nod2 signaling upon norovirus infection enhances antiviral immunity and susceptibility to colitis.
Read more22 Nov 2023
event
Joint Microbiology and Computational Biology departments seminar: Yves Brun (University of Montreal, Canada) “Antimicrobial discovery by artificial intelligence-assisted high throughput microscopy” ; Wednesday 13 December @10.30am ; Agnes Ullman Amphitheater.
Read more26 Sep 2023
publication
Standardized high-dimensional spectral cytometry protocol and panels for whole blood immune phenotyping in clinical and translational studies.
Read more01 Aug 2023
publication
Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks.
Read more17 Jul 2023
publication
Cell envelope growth of Gram-negative bacteria proceeds independently of cell wall synthesis.
Read more05 Apr 2023
event
Symposium on Microbial Extracellular Vesicles ; June 15th, 2023 ; Auditorium François Jacob
Read more24 Feb 2023
publication
Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice.
Read more24 Jan 2023
publication
Microbiota-induced active translocation of peptidoglycan across the intestinal barrier dictates its within-host dissemination.
Read more04 Jan 2023
publication
Leptospira interrogans Prevents Macrophage Cell Death and Pyroptotic IL-1β Release through Its Atypical Lipopolysaccharide.
Read more23 Nov 2022
06 Oct 2022
05 Oct 2022
publication
Escherichia coli-Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer.
Read more20 Sep 2022
publication
A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp.
Read more26 Jul 2022
28 Jun 2022
publication
Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation.
Read more20 Jun 2022
publication
Variability of Primary Sjögren’s Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA-DQ Locus.
Read more02 May 2022
publication
Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy.
Read more16 Apr 2022
15 Apr 2022
15 Apr 2022
publication
Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus.
Read more09 Mar 2022
publication
Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.
Read more20 Jan 2022
01 Jan 2022
01 Jan 2022
publication
Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagella.
Read more01 Jan 2022
publication
Alive Pathogenic and Saprophytic Leptospires Enter and Exit Human and Mouse Macrophages With No Intracellular Replication.
Read more28 Sep 2021
publication
PGFinder, a novel analysis pipeline for the consistent, reproducible, and high-resolution structural analysis of bacterial peptidoglycans.
Read more19 Aug 2021
publication
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
Read more01 Jul 2021
publication
Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate.
Read more01 Jul 2021
01 May 2021
publication
Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients.
Read more01 Apr 2021
publication
Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo.
Read more01 Mar 2021
publication
Is This a Healthy Scientific Controversy or the “Savior” Syndrome at Play? COVID-19 and the Hydroxychloroquine Example.
Read more03 Feb 2021
publication
A Secreted NlpC/P60 Endopeptidase from Photobacterium damselae subsp. piscicida Cleaves the Peptidoglycan of Potentially Competing Bacteria.
Read more01 Jan 2021
publication
Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols.
Read more01 Jan 2021
publication
LpxT-Dependent Phosphorylation of Lipid A in Escherichia coli Increases Resistance to Deoxycholate and Enhances Gut Colonization.
Read more11 Dec 2020
publication
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system.
Read more01 Dec 2020
publication
Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system.
Read more24 Nov 2020
event
Seminar DPT Microbiology “Brucella abortus, a polarized bacterial pathogen with a peculiar envelope”, Prof. Xavier De Bolle
Read more24 Nov 2020
event
Seminar DPT Microbiology “Transmission of Respiratory Pathogens”, Dr. Jeffrey Weiser
Read more23 Nov 2020
publication
A peptide of a type I toxin-antitoxin system induces Helicobacter pylori morphological transformation from spiral shape to coccoids.
Read more03 Nov 2020
event
Seminar DPT Microbiology – “From stress to success: how actinobacteria exploit life without a cell wall”, Dr. Dennis CLAESSEN
Read more23 Oct 2020
publication
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Read more16 Oct 2020
publication
Immune Profiling Enables Stratification of Patients With Active Tuberculosis Disease or Mycobacterium tuberculosis Infection.
Read more13 Oct 2020
event
Microbiology DPT Seminar ““Radically new enzymes for antibiotic and natural product biosynthesis” Dr Olivier BERTEAU
Read more13 Oct 2020
event
Microbiology DPT seminar “The Role of cAMP signalling in Antibiotics Tolerance in Mycobacterium tuberculosis” Dr. Gerald LARROUY-MAUMUS
Read more08 Sep 2020
21 Aug 2020
publication
Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage.
Read more10 Aug 2020
01 Aug 2020
publication
Leptospiral LPS escapes mouse TLR4 internalization and TRIF‑associated antimicrobial responses through O antigen and associated lipoproteins.
Read more01 Jun 2020
publication
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer.
Read more05 Feb 2020
publication
Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis.
Read more01 Jan 2020
publication
Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.
Read more01 Jan 2020
publication
Study of the cwaRS-ldcA Operon Coding a Two-Component System and a Putative L,D-Carboxypeptidase in Lactobacillus paracasei.
Read more05 Sep 2019
publication
HupA, the main undecaprenyl pyrophosphate and phosphatidylglycerol phosphate phosphatase in Helicobacter pylori is essential for colonization of the stomach
Read more04 Sep 2019
project
Proof of concept of the impact of gut microbiota in the clinical outcome of ICB in mouse models of cancer
Read more01 Sep 2019
publication
A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.
Read more01 May 2019
publication
Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection.
Read more01 Apr 2019
22 Nov 2018
event
Department of Microbiology – Thesis Defense “Dissecting peptidoglycan trafficking and transport(ers) in Human cells” by Christiane Brenner
Read more22 Nov 2018
event
Department of Microbiology: «How bacteriophages protect themselves from CRISPR» by Joe Bondy Denomy
Read more28 Sep 2018
publication
Deacetylases required for muramic-δ-lactam production are involved in sporulation, germination, and heat resistance
Read more17 Jan 2018
01 Dec 2017
publication
LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition.
Read more03 Oct 2017
publication
Molecular architecture of the PBP2-MreC core bacterial cell wall synthesis complex
Read more20 Sep 2017
publication
Lactobacillus paracasei feeding improves immune control of influenza infection in mice.
Read more30 Aug 2017
publication
Nitrosative stress defences of the enterohepatic pathogenic bacterium Helicobacter pullorum
Read more29 May 2017
event
Department of Microbiology – Seminar by Jason Paxman, University of Melbourne (Australia)
Read more29 May 2017
event
“Analyse métabolomique : enjeux technologiques et applications biomédicales” by Christophe JUNOT – MICROBIOLOGY DEPARTMENT SEMINAR
Read more19 May 2017
publication
Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2 signaling
Read more05 Apr 2017
22 Feb 2017
publication
Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases.
Read more02 Jan 2017
04 Oct 2016
publication
Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects
Read more06 Sep 2016
publication
Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses.
Read more29 Jul 2016
22 Jul 2016
publication
Role of the N-Acetylmuramoyl-l-Alanyl Amidase, AmiA, of Helicobacter pylori in Peptidoglycan Metabolism, Daughter Cell Separation, and Virulence
Read more08 Jul 2016
29 Jun 2016
21 Jun 2016
publication
Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors
Read more03 Jun 2016
18 Feb 2016
publication
Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota
Read more05 Nov 2015
01 Nov 2015
05 Oct 2015
14 Sep 2015
17 Jul 2015
17 Jul 2015
09 Jul 2015
02 Jul 2015
01 Jul 2015
11 May 2015
01 Oct 2014
publication
Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Read more01 Sep 2014
publication
FrxA is an S-nitrosoglutathione reductase enzyme that contributes to Helicobacter pylori pathogenicity
Read more25 Aug 2014
publication
Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes
Read more29 Jul 2014
02 Jun 2014
publication
The biology of bacterial peptidoglycans and their impact on host immunity and physiology
Read more01 Jun 2014
16 May 2014
15 May 2014
publication
N-acetylglucosamine deacetylases modulate the anchoring of the gamma-glutamyl capsule to the cell wall of Bacillus anthracis
Read more28 Apr 2014
publication
Chemokines and antimicrobial peptides have a cag-dependent early response to Helicobacter pylori infection in primary human gastric epithelial cells
Read more21 Apr 2014
publication
The lacdiNAc-specific adhesin LabA mediates adhesion of Helicobacter pylori to human gastric mucosa
Read more17 Apr 2014
publication
The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling
Read more15 Apr 2014
publication
CCL17 production by dendritic cells is required for NOD1-mediated exacerbation of allergic asthma
Read more17 Jan 2014
01 Jan 2014
publication
Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways.
Read more19 Dec 2013
22 Nov 2013
publication
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
Read more21 Nov 2013
publication
N-glycolylated peptidoglycan contributes to the immunogenicity but not pathogenicity of Mycobacterium tuberculosis
Read more15 Nov 2013
publication
The dynamics of peptidoglycan structure and function: conference report on the 3rd Great Wall Symposium
Read more20 Sep 2013
publication
Listeria monocytogenes multidrug resistance transporters and cyclic di-AMP, which contribute to type I interferon induction, play a role in cell wall stress
Read more12 Jul 2013
publication
The functional vanGCd cluster of Clostridium difficile does not confer vancomycin resistance
Read more12 Jun 2013
publication
Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.
Read more05 Apr 2013
publication
Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid
Read more05 Apr 2013
publication
Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid.
Read more12 Feb 2013
publication
Inheritance of the lysozyme inhibitor Ivy was an important evolutionary step by Yersinia pestis to avoid the host innate immune response
Read more21 Jan 2013
publication
Distinct functions of polysaccharide deacetylases in cell shape, neutral polysaccharide synthesis and virulence of Bacillus anthracis
Read more06 Dec 2012
publication
Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells
Read more21 Sep 2012
16 Aug 2012
publication
Peptidoglycan sensing by the receptor PGRP-LE in the Drosophila gut induces immune responses to infectious bacteria and tolerance to microbiota
Read more01 Jun 2012
publication
The effect of bulgecin A on peptidoglycan metabolism and physiology of Helicobacter pylori.
Read more21 Apr 2012
publication
Almost all human gastric mucin O-glycans harbor blood group A, B or H antigens and are potential binding sites for Helicobacter pylori
Read more15 Mar 2012
publication
Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.
Read more06 Mar 2012
22 Dec 2011
publication
Helicobacter pylori versus the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa
Read more07 Nov 2011
publication
Super-resolution microscopy reveals cell wall dynamics and peptidoglycan architecture in ovococcal bacteria
Read more27 Oct 2011
publication
Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor 4
Read more08 Oct 2011
publication
Expression and functional importance of innate immune receptors by intestinal epithelial cells
Read more15 Sep 2011
publication
Characterization of the elongasome core PBP2 : MreC complex of Helicobacter pylori
Read more01 Sep 2011
publication
OatA, a peptidoglycan O-acetyltransferase involved in Listeria monocytogenes immune escape, is critical for virulence.
Read more19 Jul 2011
publication
Mycolactone diffuses into the peripheral blood of Buruli ulcer patients–implications for diagnosis and disease monitoring
Read more06 Apr 2011
publication
Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide
Read more27 Sep 2010
publication
A M23B family metallopeptidase of Helicobacter pylori required for cell shape, pole formation and virulence
Read more24 Jun 2010
10 Jun 2010
publication
From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma.
Read more10 Jun 2010
publication
From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma
Read more21 Dec 2009
publication
The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides
Read more08 Nov 2009
publication
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
Read more29 Apr 2009
publication
A commensal Helicobacter sp. of the rodent intestinal flora activates TLR2 and NOD1 responses in epithelial cells
Read more19 Feb 2009
01 Feb 2008
publication
Development of inducible systems to engineer conditional mutants of essential genes of Helicobacter pylori
Read more07 Sep 2007
publication
New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus
Read more21 Jul 2007
publication
HobA–a novel protein involved in initiation of chromosomal replication in Helicobacter pylori
Read more08 Feb 2007
16 Jan 2007
publication
A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system.
Read more03 Nov 2006
01 Sep 2006
publication
Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape.
Read more24 Feb 2006
publication
Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2
Read more02 Sep 2005
22 Aug 2005
publication
The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists
Read more16 Jun 2005
publication
Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis
Read more01 Feb 2005
15 Dec 2004
publication
Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway
Read more17 Oct 2004
publication
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
Read more01 Oct 2004
publication
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition.
Read more26 Sep 2004
publication
Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria
Read more18 Jul 2003
01 Jun 2003
15 Mar 2003
13 Jan 2003
publication
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
Read more01 Nov 2002
24 Aug 2001
publication
Selective cleavage of D-Ala-D-Lac by small molecules: re-sensitizing resistant bacteria to vancomycin
Read more01 Apr 2000
publication
Characterization of Staphylococcus aureus cell wall glycan strands, evidence for a new beta-N-acetylglucosaminidase activity
Read more14 Nov 1997
publication