Timeline

Ivo Gomperts Boneca
Head of Structure
08 Aug 2024
publication

Local Receptor-interacting Protein Kinase 2 inhibition mitigates HDM-induced asthma.

Read more
18 Mar 2024
event

Symposium “Microbial Cell Wall” ; Monday, June 3rd ; Amphitheater Agnès Ullmann

Read more
01 Feb 2024
publication

The shapeshifting Helicobacter pylori: From a corkscrew to a ball.

Read more
06 Jan 2024
publication

Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake.

Read more
26 Dec 2023
publication

Identification of a muropeptide precursor transporter from gut microbiota and its role in preventing intestinal inflammation.

Read more
09 Dec 2023
publication

Leptospiral lipopolysaccharide dampens inflammation through upregulation of autophagy adaptor p62 and NRF2 signaling in macrophages.

Read more
01 Dec 2023
publication

Activation of Nod2 signaling upon norovirus infection enhances antiviral immunity and susceptibility to colitis.

Read more
22 Nov 2023
event

Joint Microbiology and Computational Biology departments seminar: Yves Brun (University of Montreal, Canada) “Antimicrobial discovery by artificial intelligence-assisted high throughput microscopy” ; Wednesday 13 December @10.30am ; Agnes Ullman Amphitheater.

Read more
26 Sep 2023
publication

Standardized high-dimensional spectral cytometry protocol and panels for whole blood immune phenotyping in clinical and translational studies.

Read more
01 Aug 2023
publication

Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks.

Read more
17 Jul 2023
publication

Cell envelope growth of Gram-negative bacteria proceeds independently of cell wall synthesis.

Read more
05 Apr 2023
event

Symposium on Microbial Extracellular Vesicles ; June 15th, 2023 ; Auditorium François Jacob

Read more
24 Feb 2023
publication

Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice.

Read more
24 Jan 2023
publication

Microbiota-induced active translocation of peptidoglycan across the intestinal barrier dictates its within-host dissemination.

Read more
04 Jan 2023
publication

Leptospira interrogans Prevents Macrophage Cell Death and Pyroptotic IL-1β Release through Its Atypical Lipopolysaccharide.

Read more
23 Nov 2022
event

Dept Microbiology | Seminar “Profiling Pseudomonas aeruginosa infections”

Read more
06 Oct 2022
publication

The immune factors driving DNA methylation variation in human blood.

Read more
05 Oct 2022
publication

Escherichia coli-Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer.

Read more
20 Sep 2022
publication

A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp

Read more
26 Jul 2022
event

Cell division and cell wall mechanisms – Mini symposium 26th October 2022

Read more
28 Jun 2022
publication

Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation.

Read more
20 Jun 2022
publication

Variability of Primary Sjögren’s Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA-DQ Locus.

Read more
02 May 2022
publication

Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy.

Read more
16 Apr 2022
news

Gut microbes regulate appetite and body temperature

Read more
15 Apr 2022
publication

Bacterial sensing via neuronal Nod2 regulates appetite and body temperature.

Read more
15 Apr 2022
publication

Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus.

Read more
09 Mar 2022
publication

Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.

Read more
20 Jan 2022
team

U1306 – Host-Microbe interactions and pathophysiology

Read more
01 Jan 2022
publication

NOD-like receptors in asthma.

Read more
01 Jan 2022
publication

Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagella.

Read more
01 Jan 2022
publication

Alive Pathogenic and Saprophytic Leptospires Enter and Exit Human and Mouse Macrophages With No Intracellular Replication.

Read more
28 Sep 2021
publication

PGFinder, a novel analysis pipeline for the consistent, reproducible, and high-resolution structural analysis of bacterial peptidoglycans.

Read more
19 Aug 2021
publication

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.

Read more
01 Jul 2021
publication

Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate.

Read more
01 Jul 2021
publication

Multifaceted modes of action of the anticancer probiotic Enterococcus hirae.

Read more
01 May 2021
publication

Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients.

Read more
01 Apr 2021
publication

Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo.

Read more
01 Mar 2021
publication

Is This a Healthy Scientific Controversy or the “Savior” Syndrome at Play? COVID-19 and the Hydroxychloroquine Example.

Read more
03 Feb 2021
publication

A Secreted NlpC/P60 Endopeptidase from Photobacterium damselae subsp. piscicida Cleaves the Peptidoglycan of Potentially Competing Bacteria.

Read more
01 Jan 2021
publication

Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols.

Read more
01 Jan 2021
publication

LpxT-Dependent Phosphorylation of Lipid A in Escherichia coli Increases Resistance to Deoxycholate and Enhances Gut Colonization.

Read more
11 Dec 2020
publication

Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system.

Read more
01 Dec 2020
publication

Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system.

Read more
24 Nov 2020
event

Seminar DPT Microbiology “Brucella abortus, a polarized bacterial pathogen with a peculiar envelope”, Prof. Xavier De Bolle

Read more
24 Nov 2020
event

Seminar DPT Microbiology “Transmission of Respiratory Pathogens”, Dr. Jeffrey Weiser

Read more
23 Nov 2020
publication

A peptide of a type I toxin-antitoxin system induces Helicobacter pylori morphological transformation from spiral shape to coccoids.

Read more
03 Nov 2020
event

Seminar DPT Microbiology – “From stress to success: how actinobacteria exploit life without a cell wall”, Dr. Dennis CLAESSEN

Read more
23 Oct 2020
publication

Autoantibodies against type I IFNs in patients with life-threatening COVID-19.

Read more
16 Oct 2020
publication

Immune Profiling Enables Stratification of Patients With Active Tuberculosis Disease or Mycobacterium tuberculosis Infection.

Read more
13 Oct 2020
event

Microbiology DPT Seminar ““Radically new enzymes for antibiotic and natural product biosynthesis” Dr Olivier BERTEAU

Read more
13 Oct 2020
event

Microbiology DPT seminar “The Role of cAMP signalling in Antibiotics Tolerance in Mycobacterium tuberculosis” Dr. Gerald LARROUY-MAUMUS

Read more
08 Sep 2020
publication

Uptake, recognition and responses to peptidoglycan in the mammalian host.

Read more
21 Aug 2020
publication

Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage.

Read more
10 Aug 2020
news

Gut microbiota plays a role in brain function and mood regulation

Read more
01 Aug 2020
publication

Leptospiral LPS escapes mouse TLR4 internalization and TRIF‑associated antimicrobial responses through O antigen and associated lipoproteins.

Read more
01 Jun 2020
publication

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer.

Read more
05 Feb 2020
publication

Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis.

Read more
01 Jan 2020
publication

Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.

Read more
01 Jan 2020
publication

Study of the cwaRS-ldcA Operon Coding a Two-Component System and a Putative L,D-Carboxypeptidase in Lactobacillus paracasei.

Read more
05 Sep 2019
publication

HupA, the main undecaprenyl pyrophosphate and phosphatidylglycerol phosphate phosphatase in Helicobacter pylori is essential for colonization of the stomach

Read more
04 Sep 2019
project

Proof of concept of the impact of gut microbiota in the clinical outcome of ICB in mouse models of cancer

Read more
01 Sep 2019
publication

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.

Read more
01 May 2019
publication

Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection.

Read more
01 Apr 2019
project

Organ-on-Chip Center

Read more
22 Nov 2018
event

Department of Microbiology – Thesis Defense “Dissecting peptidoglycan trafficking and transport(ers) in Human cells” by Christiane Brenner

Read more
22 Nov 2018
event

Department of Microbiology: «How bacteriophages protect themselves from CRISPR» by Joe Bondy Denomy

Read more
28 Sep 2018
publication

Deacetylases required for muramic-δ-lactam production are involved in sporulation, germination, and heat resistance

Read more
17 Jan 2018
event

LUCA and the universal tree of life: an update

Read more
01 Dec 2017
publication

LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition.

Read more
03 Oct 2017
publication

Molecular architecture of the PBP2-MreC core bacterial cell wall synthesis complex

Read more
20 Sep 2017
publication

Lactobacillus paracasei feeding improves immune control of influenza infection in mice.

Read more
30 Aug 2017
publication

Nitrosative stress defences of the enterohepatic pathogenic bacterium Helicobacter pullorum

Read more
29 May 2017
event

Department of Microbiology – Seminar by Jason Paxman, University of Melbourne (Australia)

Read more
29 May 2017
event

“Analyse métabolomique : enjeux technologiques et applications biomédicales” by Christophe JUNOT – MICROBIOLOGY DEPARTMENT SEMINAR

Read more
19 May 2017
publication

Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2 signaling

Read more
05 Apr 2017
publication

Unusual α-Carbon Hydroxylation of Proline Promotes Active-Site Maturation

Read more
22 Feb 2017
publication

Bulgecin A: The Key to a Broad-Spectrum Inhibitor  That Targets Lytic Transglycosylases.

Read more
02 Jan 2017
project

Inhibition of peptidoglycan assembly complexes

Read more
04 Oct 2016
publication

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

Read more
06 Sep 2016
publication

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses.

Read more
29 Jul 2016
publication

Fine-Tuning Cancer Immunotherapy: Optimizing the Gut Microbiome

Read more
22 Jul 2016
publication

Role of the N-Acetylmuramoyl-l-Alanyl Amidase, AmiA, of Helicobacter pylori in Peptidoglycan Metabolism, Daughter Cell Separation, and Virulence

Read more
08 Jul 2016
project

Adult neurogenesis and brain plasticity

Read more
29 Jun 2016
publication

The 4(th) Great Wall Symposium, 2015

Read more
21 Jun 2016
publication

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

Read more
03 Jun 2016
project

Think tank: Mucosal Immunology

Read more
18 Feb 2016
publication

Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota

Read more
05 Nov 2015
publication

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Read more
01 Nov 2015
publication

Paenibacillus faecis sp. nov., isolated from human faeces

Read more
05 Oct 2015
news

Sofia Pombo new PhD student in the BGPB Unit

Read more
14 Sep 2015
project

ERC-2007-Stg-202283-PGNfromSHAPEtoVIR

Read more
17 Jul 2015
project

When Gut Bacteria Changes Brain Functions

Read more
17 Jul 2015
tool

Optogenetic

Read more
09 Jul 2015
publication

The microbiota regulates type 2 immunity through RORγt⁺ T cells

Read more
02 Jul 2015
project

Biology and Genetics of Bacterial Cell Wall

Read more
01 Jul 2015
project

Symbiotic microbiota and the development and regulation of the immune system

Read more
11 May 2015
team

Biology and Genetics of Bacterial Cell Wall

Read more
01 Oct 2014
publication

Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.

Read more
01 Sep 2014
publication

FrxA is an S-nitrosoglutathione reductase enzyme that contributes to Helicobacter pylori pathogenicity

Read more
25 Aug 2014
publication

Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes

Read more
29 Jul 2014
publication

Harnessing the intestinal microbiome for optimal therapeutic immunomodulation

Read more
02 Jun 2014
publication

The biology of bacterial peptidoglycans and their impact on host immunity and physiology

Read more
01 Jun 2014
publication

The Great Wall Symposium

Read more
16 May 2014
publication

Gut microbiome and anticancer immune response: really hot Sh*t!

Read more
15 May 2014
publication

N-acetylglucosamine deacetylases modulate the anchoring of the gamma-glutamyl capsule to the cell wall of Bacillus anthracis

Read more
28 Apr 2014
publication

Chemokines and antimicrobial peptides have a cag-dependent early response to Helicobacter pylori infection in primary human gastric epithelial cells

Read more
21 Apr 2014
publication

The lacdiNAc-specific adhesin LabA mediates adhesion of Helicobacter pylori to human gastric mucosa

Read more
17 Apr 2014
publication

The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling

Read more
15 Apr 2014
publication

CCL17 production by dendritic cells is required for NOD1-mediated exacerbation of allergic asthma

Read more
17 Jan 2014
publication

Why should we need the gut microbiota to respond to cancer therapies?

Read more
01 Jan 2014
publication

Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways.

Read more
19 Dec 2013
publication

Draft Genome Sequence of Strain X47-2AL, a Feline Helicobacter pylori Isolate

Read more
22 Nov 2013
publication

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide

Read more
21 Nov 2013
publication

N-glycolylated peptidoglycan contributes to the immunogenicity but not pathogenicity of Mycobacterium tuberculosis

Read more
15 Nov 2013
publication

The dynamics of peptidoglycan structure and function: conference report on the 3rd Great Wall Symposium

Read more
20 Sep 2013
publication

Listeria monocytogenes multidrug resistance transporters and cyclic di-AMP, which contribute to type I interferon induction, play a role in cell wall stress

Read more
12 Jul 2013
publication

The functional vanGCd cluster of Clostridium difficile does not confer vancomycin resistance

Read more
12 Jun 2013
publication

Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.

Read more
05 Apr 2013
publication

Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid

Read more
05 Apr 2013
publication

Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid.

Read more
12 Feb 2013
publication

Inheritance of the lysozyme inhibitor Ivy was an important evolutionary step by Yersinia pestis to avoid the host innate immune response

Read more
21 Jan 2013
publication

Distinct functions of polysaccharide deacetylases in cell shape, neutral polysaccharide synthesis and virulence of Bacillus anthracis

Read more
06 Dec 2012
publication

Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells

Read more
21 Sep 2012
publication

Peptidoglycan maturation enzymes affect flagellar functionality in bacteria

Read more
16 Aug 2012
publication

Peptidoglycan sensing by the receptor PGRP-LE in the Drosophila gut induces immune responses to infectious bacteria and tolerance to microbiota

Read more
01 Jun 2012
publication

The effect of bulgecin A on peptidoglycan metabolism and physiology of Helicobacter pylori.

Read more
21 Apr 2012
publication

Almost all human gastric mucin O-glycans harbor blood group A, B or H antigens and are potential binding sites for Helicobacter pylori

Read more
15 Mar 2012
publication

Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.

Read more
06 Mar 2012
publication

Helicobacter pylori has an unprecedented nitric oxide detoxifying system

Read more
22 Dec 2011
publication

Helicobacter pylori versus the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa

Read more
07 Nov 2011
publication

Super-resolution microscopy reveals cell wall dynamics and peptidoglycan architecture in ovococcal bacteria

Read more
27 Oct 2011
publication

Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor 4

Read more
08 Oct 2011
publication

Expression and functional importance of innate immune receptors by intestinal epithelial cells

Read more
15 Sep 2011
publication

Characterization of the elongasome core PBP2 : MreC complex of Helicobacter pylori

Read more
01 Sep 2011
publication

OatA, a peptidoglycan O-acetyltransferase involved in Listeria monocytogenes immune escape, is critical for virulence.

Read more
19 Jul 2011
publication

Mycolactone diffuses into the peripheral blood of Buruli ulcer patients–implications for diagnosis and disease monitoring

Read more
06 Apr 2011
publication

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

Read more
27 Sep 2010
publication

A M23B family metallopeptidase of Helicobacter pylori required for cell shape, pole formation and virulence

Read more
24 Jun 2010
publication

Bacteria and MAMP-induced morphogenesis of the immune system.

Read more
10 Jun 2010
publication

From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma.

Read more
10 Jun 2010
publication

From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma

Read more
21 Dec 2009
publication

The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides

Read more
08 Nov 2009
publication

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

Read more
29 Apr 2009
publication

A commensal Helicobacter sp. of the rodent intestinal flora activates TLR2 and NOD1 responses in epithelial cells

Read more
19 Feb 2009
publication

Mammalian PGRPs in the spotlight

Read more
01 Feb 2008
publication

Development of inducible systems to engineer conditional mutants of essential genes of Helicobacter pylori

Read more
07 Sep 2007
publication

New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus

Read more
21 Jul 2007
publication

HobA–a novel protein involved in initiation of chromosomal replication in Helicobacter pylori

Read more
08 Feb 2007
publication

Peptidoglycan detection by mammals and flies

Read more
16 Jan 2007
publication

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system.

Read more
03 Nov 2006
publication

Characterization of Helicobacter pylori lytic transglycosylases Slt and MltD

Read more
01 Sep 2006
publication

Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape.

Read more
24 Feb 2006
publication

Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2

Read more
02 Sep 2005
publication

Nod1 participates in the innate immune response to Pseudomonas aeruginosa

Read more
22 Aug 2005
publication

The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists

Read more
16 Jun 2005
publication

Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis

Read more
01 Feb 2005
publication

The role of peptidoglycan in pathogenesis

Read more
15 Dec 2004
publication

Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway

Read more
17 Oct 2004
publication

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

Read more
01 Oct 2004
publication

Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition.

Read more
26 Sep 2004
publication

Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria

Read more
18 Jul 2003
publication

Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2

Read more
01 Jun 2003
publication

Vancomycin resistance: occurrence, mechanisms and strategies to combat it

Read more
15 Mar 2003
publication

A revised annotation and comparative analysis of Helicobacter pylori genomes

Read more
13 Jan 2003
publication

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

Read more
01 Nov 2002
publication

Prediction, assessment and validation of protein interaction maps in bacteria

Read more
24 Aug 2001
publication

Selective cleavage of D-Ala-D-Lac by small molecules: re-sensitizing resistant bacteria to vancomycin

Read more
01 Apr 2000
publication

Characterization of Staphylococcus aureus cell wall glycan strands, evidence for a new beta-N-acetylglucosaminidase activity

Read more
14 Nov 1997
publication

Structural characterization of an abnormally cross-linked muropeptide dimer that is accumulated in the peptidoglycan of methicillin- and cefotaxime-resistant mutants of Staphylococcus aureus

Read more