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© Research
Publication : The Journal of biological chemistry

Nod1 participates in the innate immune response to Pseudomonas aeruginosa

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of biological chemistry - 02 Sep 2005

Travassos LH, Carneiro LA, Girardin SE, Boneca IG, Lemos R, Bozza MT, Domingues RC, Coyle AJ, Bertin J, Philpott DJ, Plotkowski MC

Link to Pubmed [PMID] – 16150702

J. Biol. Chem. 2005 Nov;280(44):36714-8

The mammalian innate immune system recognizes pathogen-associated molecular patterns through pathogen recognition receptors. Nod1 has been described recently as a cytosolic receptor that detects specifically diaminopimelate-containing muropeptides from Gram-negative bacteria peptidoglycan. In the present study we investigated the potential role of Nod1 in the innate immune response against the opportunistic pathogen Pseudomonas aeruginosa. We demonstrate that Nod1 detects the P. aeruginosa peptidoglycan leading to NF-kappaB activation and that this activity is diminished in epithelial cells expressing a dominant-negative Nod1 construct or in mouse embryonic fibroblasts from Nod1 knock-out mice infected with P. aeruginosa. Finally, we demonstrate that the cytokine secretion kinetics and bacterial killing are altered in Nod1-deficient cells infected with P. aeruginosa in the early stages of infection.

http://www.ncbi.nlm.nih.gov/pubmed/16150702