Ligne de temps
Ivo Gomperts Boneca
Responsable de Structure
18 mars 2024
01 févr. 2024
06 janv. 2024
publication
Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake.
Lire plus26 déc. 2023
publication
Identification of a muropeptide precursor transporter from gut microbiota and its role in preventing intestinal inflammation.
Lire plus09 déc. 2023
publication
Leptospiral lipopolysaccharide dampens inflammation through upregulation of autophagy adaptor p62 and NRF2 signaling in macrophages.
Lire plus01 déc. 2023
publication
Activation of Nod2 signaling upon norovirus infection enhances antiviral immunity and susceptibility to colitis.
Lire plus22 nov. 2023
event
Joint Microbiology and Computational Biology departments seminar: Yves Brun (University of Montreal, Canada) “Antimicrobial discovery by artificial intelligence-assisted high throughput microscopy” ; Wednesday 13 December @10.30am ; Agnes Ullman Amphitheater.
Lire plus26 sept. 2023
publication
Standardized high-dimensional spectral cytometry protocol and panels for whole blood immune phenotyping in clinical and translational studies.
Lire plus01 août 2023
publication
Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks.
Lire plus17 juil. 2023
publication
Cell envelope growth of Gram-negative bacteria proceeds independently of cell wall synthesis.
Lire plus05 avr. 2023
event
Symposium on Microbial Extracellular Vesicles ; June 15th, 2023 ; Auditorium François Jacob
Lire plus24 févr. 2023
publication
Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice.
Lire plus24 janv. 2023
publication
Microbiota-induced active translocation of peptidoglycan across the intestinal barrier dictates its within-host dissemination.
Lire plus04 janv. 2023
publication
Leptospira interrogans Prevents Macrophage Cell Death and Pyroptotic IL-1β Release through Its Atypical Lipopolysaccharide.
Lire plus23 nov. 2022
06 oct. 2022
05 oct. 2022
publication
Escherichia coli-Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer.
Lire plus20 sept. 2022
publication
A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp.
Lire plus26 juil. 2022
28 juin 2022
publication
Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation.
Lire plus20 juin 2022
publication
Variability of Primary Sjögren’s Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA-DQ Locus.
Lire plus02 mai 2022
publication
Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy.
Lire plus16 avr. 2022
15 avr. 2022
15 avr. 2022
publication
Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus.
Lire plus09 mars 2022
publication
Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.
Lire plus20 janv. 2022
01 janv. 2022
publication
Alive Pathogenic and Saprophytic Leptospires Enter and Exit Human and Mouse Macrophages With No Intracellular Replication.
Lire plus01 janv. 2022
01 janv. 2022
publication
Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagella.
Lire plus28 sept. 2021
publication
PGFinder, a novel analysis pipeline for the consistent, reproducible, and high-resolution structural analysis of bacterial peptidoglycans.
Lire plus19 août 2021
publication
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
Lire plus01 juil. 2021
01 juil. 2021
publication
Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate.
Lire plus01 mai 2021
publication
Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients.
Lire plus01 avr. 2021
publication
Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo.
Lire plus01 mars 2021
publication
Is This a Healthy Scientific Controversy or the “Savior” Syndrome at Play? COVID-19 and the Hydroxychloroquine Example.
Lire plus03 févr. 2021
publication
A Secreted NlpC/P60 Endopeptidase from Photobacterium damselae subsp. piscicida Cleaves the Peptidoglycan of Potentially Competing Bacteria.
Lire plus01 janv. 2021
publication
Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols.
Lire plus01 janv. 2021
publication
LpxT-Dependent Phosphorylation of Lipid A in Escherichia coli Increases Resistance to Deoxycholate and Enhances Gut Colonization.
Lire plus11 déc. 2020
publication
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system.
Lire plus01 déc. 2020
publication
Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system.
Lire plus24 nov. 2020
event
Seminar DPT Microbiology “Brucella abortus, a polarized bacterial pathogen with a peculiar envelope”, Prof. Xavier De Bolle
Lire plus24 nov. 2020
event
Seminar DPT Microbiology “Transmission of Respiratory Pathogens”, Dr. Jeffrey Weiser
Lire plus23 nov. 2020
publication
A peptide of a type I toxin-antitoxin system induces Helicobacter pylori morphological transformation from spiral shape to coccoids.
Lire plus03 nov. 2020
event
Seminar DPT Microbiology – “From stress to success: how actinobacteria exploit life without a cell wall”, Dr. Dennis CLAESSEN
Lire plus23 oct. 2020
publication
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Lire plus16 oct. 2020
publication
Immune Profiling Enables Stratification of Patients With Active Tuberculosis Disease or Mycobacterium tuberculosis Infection.
Lire plus13 oct. 2020
event
Microbiology DPT Seminar ““Radically new enzymes for antibiotic and natural product biosynthesis” Dr Olivier BERTEAU
Lire plus13 oct. 2020
event
Microbiology DPT seminar “The Role of cAMP signalling in Antibiotics Tolerance in Mycobacterium tuberculosis” Dr. Gerald LARROUY-MAUMUS
Lire plus08 sept. 2020
21 août 2020
publication
Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage.
Lire plus10 août 2020
01 août 2020
publication
Leptospiral LPS escapes mouse TLR4 internalization and TRIF‑associated antimicrobial responses through O antigen and associated lipoproteins.
Lire plus01 juin 2020
publication
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer.
Lire plus05 févr. 2020
publication
Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis.
Lire plus01 janv. 2020
publication
Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.
Lire plus01 janv. 2020
publication
Study of the cwaRS-ldcA Operon Coding a Two-Component System and a Putative L,D-Carboxypeptidase in Lactobacillus paracasei.
Lire plus05 sept. 2019
publication
HupA, the main undecaprenyl pyrophosphate and phosphatidylglycerol phosphate phosphatase in Helicobacter pylori is essential for colonization of the stomach
Lire plus04 sept. 2019
project
Proof of concept of the impact of gut microbiota in the clinical outcome of ICB in mouse models of cancer
Lire plus01 sept. 2019
publication
A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.
Lire plus01 mai 2019
publication
Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection.
Lire plus01 avr. 2019
22 nov. 2018
event
Department of Microbiology – Thesis Defense “Dissecting peptidoglycan trafficking and transport(ers) in Human cells” by Christiane Brenner
Lire plus22 nov. 2018
event
Department of Microbiology: «How bacteriophages protect themselves from CRISPR» by Joe Bondy Denomy
Lire plus28 sept. 2018
publication
Deacetylases required for muramic-δ-lactam production are involved in sporulation, germination, and heat resistance
Lire plus17 janv. 2018
01 déc. 2017
publication
LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition.
Lire plus03 oct. 2017
publication
Molecular architecture of the PBP2-MreC core bacterial cell wall synthesis complex
Lire plus20 sept. 2017
publication
Lactobacillus paracasei feeding improves immune control of influenza infection in mice.
Lire plus30 août 2017
publication
Nitrosative stress defences of the enterohepatic pathogenic bacterium Helicobacter pullorum
Lire plus29 mai 2017
event
Department of Microbiology – Seminar by Jason Paxman, University of Melbourne (Australia)
Lire plus29 mai 2017
event
“Analyse métabolomique : enjeux technologiques et applications biomédicales” by Christophe JUNOT – MICROBIOLOGY DEPARTMENT SEMINAR
Lire plus19 mai 2017
publication
Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2 signaling
Lire plus05 avr. 2017
22 févr. 2017
publication
Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases.
Lire plus02 janv. 2017
04 oct. 2016
publication
Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects
Lire plus06 sept. 2016
publication
Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses.
Lire plus29 juil. 2016
22 juil. 2016
publication
Role of the N-Acetylmuramoyl-l-Alanyl Amidase, AmiA, of Helicobacter pylori in Peptidoglycan Metabolism, Daughter Cell Separation, and Virulence
Lire plus08 juil. 2016
29 juin 2016
21 juin 2016
publication
Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors
Lire plus03 juin 2016
18 févr. 2016
publication
Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota
Lire plus05 nov. 2015
01 nov. 2015
05 oct. 2015
14 sept. 2015
17 juil. 2015
17 juil. 2015
09 juil. 2015
02 juil. 2015
01 juil. 2015
11 mai 2015
01 oct. 2014
publication
Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Lire plus01 sept. 2014
publication
FrxA is an S-nitrosoglutathione reductase enzyme that contributes to Helicobacter pylori pathogenicity
Lire plus25 août 2014
publication
Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes
Lire plus29 juil. 2014
02 juin 2014
publication
The biology of bacterial peptidoglycans and their impact on host immunity and physiology
Lire plus01 juin 2014
16 mai 2014
15 mai 2014
publication
N-acetylglucosamine deacetylases modulate the anchoring of the gamma-glutamyl capsule to the cell wall of Bacillus anthracis
Lire plus28 avr. 2014
publication
Chemokines and antimicrobial peptides have a cag-dependent early response to Helicobacter pylori infection in primary human gastric epithelial cells
Lire plus21 avr. 2014
publication
The lacdiNAc-specific adhesin LabA mediates adhesion of Helicobacter pylori to human gastric mucosa
Lire plus17 avr. 2014
publication
The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling
Lire plus15 avr. 2014
publication
CCL17 production by dendritic cells is required for NOD1-mediated exacerbation of allergic asthma
Lire plus17 janv. 2014
01 janv. 2014
publication
Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways.
Lire plus19 déc. 2013
22 nov. 2013
publication
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
Lire plus21 nov. 2013
publication
N-glycolylated peptidoglycan contributes to the immunogenicity but not pathogenicity of Mycobacterium tuberculosis
Lire plus15 nov. 2013
publication
The dynamics of peptidoglycan structure and function: conference report on the 3rd Great Wall Symposium
Lire plus20 sept. 2013
publication
Listeria monocytogenes multidrug resistance transporters and cyclic di-AMP, which contribute to type I interferon induction, play a role in cell wall stress
Lire plus12 juil. 2013
publication
The functional vanGCd cluster of Clostridium difficile does not confer vancomycin resistance
Lire plus12 juin 2013
publication
Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.
Lire plus05 avr. 2013
publication
Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid
Lire plus05 avr. 2013
publication
Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid.
Lire plus12 févr. 2013
publication
Inheritance of the lysozyme inhibitor Ivy was an important evolutionary step by Yersinia pestis to avoid the host innate immune response
Lire plus21 janv. 2013
publication
Distinct functions of polysaccharide deacetylases in cell shape, neutral polysaccharide synthesis and virulence of Bacillus anthracis
Lire plus06 déc. 2012
publication
Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells
Lire plus21 sept. 2012
16 août 2012
publication
Peptidoglycan sensing by the receptor PGRP-LE in the Drosophila gut induces immune responses to infectious bacteria and tolerance to microbiota
Lire plus01 juin 2012
publication
The effect of bulgecin A on peptidoglycan metabolism and physiology of Helicobacter pylori.
Lire plus21 avr. 2012
publication
Almost all human gastric mucin O-glycans harbor blood group A, B or H antigens and are potential binding sites for Helicobacter pylori
Lire plus15 mars 2012
publication
Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.
Lire plus06 mars 2012
22 déc. 2011
publication
Helicobacter pylori versus the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa
Lire plus07 nov. 2011
publication
Super-resolution microscopy reveals cell wall dynamics and peptidoglycan architecture in ovococcal bacteria
Lire plus27 oct. 2011
publication
Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor 4
Lire plus08 oct. 2011
publication
Expression and functional importance of innate immune receptors by intestinal epithelial cells
Lire plus15 sept. 2011
publication
Characterization of the elongasome core PBP2 : MreC complex of Helicobacter pylori
Lire plus01 sept. 2011
publication
OatA, a peptidoglycan O-acetyltransferase involved in Listeria monocytogenes immune escape, is critical for virulence.
Lire plus19 juil. 2011
publication
Mycolactone diffuses into the peripheral blood of Buruli ulcer patients–implications for diagnosis and disease monitoring
Lire plus06 avr. 2011
publication
Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide
Lire plus27 sept. 2010
publication
A M23B family metallopeptidase of Helicobacter pylori required for cell shape, pole formation and virulence
Lire plus24 juin 2010
10 juin 2010
publication
From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma.
Lire plus10 juin 2010
publication
From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma
Lire plus21 déc. 2009
publication
The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides
Lire plus08 nov. 2009
publication
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
Lire plus29 avr. 2009
publication
A commensal Helicobacter sp. of the rodent intestinal flora activates TLR2 and NOD1 responses in epithelial cells
Lire plus19 févr. 2009
01 févr. 2008
publication
Development of inducible systems to engineer conditional mutants of essential genes of Helicobacter pylori
Lire plus07 sept. 2007
publication
New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus
Lire plus21 juil. 2007
publication
HobA–a novel protein involved in initiation of chromosomal replication in Helicobacter pylori
Lire plus08 févr. 2007
16 janv. 2007
publication
A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system.
Lire plus03 nov. 2006
01 sept. 2006
publication
Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape.
Lire plus24 févr. 2006
publication
Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2
Lire plus02 sept. 2005
22 août 2005
publication
The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists
Lire plus16 juin 2005
publication
Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis
Lire plus01 févr. 2005
15 déc. 2004
publication
Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway
Lire plus17 oct. 2004
publication
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
Lire plus01 oct. 2004
publication
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition.
Lire plus26 sept. 2004
publication
Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria
Lire plus18 juil. 2003
01 juin 2003
15 mars 2003
13 janv. 2003
publication
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
Lire plus01 nov. 2002
24 août 2001
publication
Selective cleavage of D-Ala-D-Lac by small molecules: re-sensitizing resistant bacteria to vancomycin
Lire plus01 avr. 2000
publication
Characterization of Staphylococcus aureus cell wall glycan strands, evidence for a new beta-N-acetylglucosaminidase activity
Lire plus14 nov. 1997
publication