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© Research
Publication : Nature immunology

Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature immunology - 26 Sep 2004

Bischoff V, Vignal C, Boneca IG, Michel T, Hoffmann JA, Royet J

Link to Pubmed [PMID] – 15448690

Nat. Immunol. 2004 Nov;5(11):1175-80

The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-positive bacterial species activate an immune response in a PGRP-SA- and GNBP1-independent manner, indicating that alternative receptors exist. Consistent with this, we noted that PGRP-SD mutants were susceptible to some Gram-positive bacteria and that a loss-of-function mutation in PGRP-SD severely exacerbated the PGRP-SA and GNBP1 mutant phenotypes. These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex.

http://www.ncbi.nlm.nih.gov/pubmed/15448690