Timeline

Philippe Bastin
Head of Structure
23 Oct 2019
event

BILBO1 and the fellowship of the ring: Deciphering the composition, assembly and function of the ring of power – Mélanie Bonhivers

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14 May 2019
event

“New drugs for African trypanosomiasis from control to elimination ?” Pascal MAESER

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30 Apr 2019
publication

[Molecular motors and microtubules: which type of relationship?]

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02 Apr 2019
publication

Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly

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25 Mar 2019
publication

Indirubin analogues inhibit Glycogen Synthase Kinase 3 short and growth

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14 Feb 2019
team

Genetic and molecular basis of host-parasite interactions

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01 Feb 2019
publication

IFT25 is required for the construction of the trypanosome flagellum

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12 Nov 2018
publication

A Grow-and-Lock Model for the Control of Flagellum Length in Trypanosomes

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01 Nov 2018
publication

Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects

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10 Oct 2018
project

Role of tubulin glutamylation in flagellum construction (TUBGLUFLA)

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01 Oct 2018
publication

Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum

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24 Aug 2018
event

PhD thesis defence Eloïse Bertiaux

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25 Feb 2018
project

Centrosome dissection of T. gondii

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14 Dec 2017
publication

STEM tomography analysis of the trypanosome transition zone

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16 Nov 2017
publication

Flagellar incorporation of proteins follows at least two different routes in trypanosomes

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12 Mar 2017
publication

Preparation and Observation of Thick Biological Samples by Scanning Transmission Electron Tomography

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21 Dec 2016
event

“Composition, function and dynamics of the trypanosome flagellum transition zone”

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01 Aug 2016
publication

Intraflagellar transport is required for the maintenance of the trypanosome flagellum composition but not its length

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21 Apr 2016
event

GDR-CIL symposium on Model Organisms for Cilia Investigations

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14 Mar 2016
event

“Coat replacement dynamics in the African trypanosome”

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05 Feb 2016
project

Molecular bases for the role of IFT172 in ciliogenesis and in ciliopathy

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05 Feb 2016
project

Mode of action of intraflagellar transport

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08 Dec 2015
news

Sanofi-Pasteur Awards – Mohamed-Ali HAKIMI and Keith MATTHEWS

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30 Nov 2015
news

Symposium “Parasitology in the 21st century”

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19 Oct 2015
event

“Using tubulin cofactor C-like domains in unexpected ways to build a parasite”

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15 Oct 2015
event

“Parasitology in the 21st century”

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25 Sep 2015
event

“Decoding toxin-parasite interactions in Trypanosomatids”

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15 Sep 2015
project

Symposium ‘Parasitology in the 21st century’

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14 Aug 2015
publication

Flagellar membranes are rich in raft-forming phospholipids

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14 Aug 2015
publication

IFT81, encoding an IFT-B core protein, as a very rare cause of a ciliopathy phenotype

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28 Jul 2015
publication

The Flagellar Arginine Kinase in Trypanosoma brucei Is Important for Infection in Tsetse Flies

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08 Jul 2015
project

The Paraflagellar Rod

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03 Jul 2015
project

Trypanosomes

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29 May 2015
publication

Scanning transmission electron microscopy through-focal tilt-series on biological specimens

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11 May 2015
team

Trypanosome Cell Biology

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31 Mar 2015
publication

The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies

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07 Mar 2015
publication

Imaging intraflagellar transport in trypanosomes

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08 Jan 2015
publication

Social motility in African trypanosomes: fact or model?

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31 Dec 2014
publication

Generation of a nanobody targeting the paraflagellar rod protein of trypanosomes

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10 Nov 2014
publication

[Elongation of the axoneme and dynamics of intraflagellar transport]

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02 Jul 2014
publication

The intraflagellar transport dynein complex of trypanosomes is made of a heterodimer of dynein heavy chains and of light and intermediate chains of distinct functions

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23 May 2014
publication

The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status

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24 Apr 2014
publication

The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport

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16 Apr 2014
publication

Proteomic analysis of intact flagella of procyclic Trypanosoma brucei cells identifies novel flagellar proteins with unique sub-localization and dynamics

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18 Mar 2014
publication

Boarder control on the IFT train

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29 Nov 2013
publication

Getting to the heart of intraflagellar transport using Trypanosoma and Chlamydomonas models: the strength is in their differences

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13 Nov 2013
publication

More than meets the eye: understanding Trypanosoma brucei morphology in the tsetse

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05 Nov 2013
publication

Forward motility is essential for trypanosome infection in the tsetse fly

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25 Oct 2013
publication

Flagellar adhesion in Trypanosoma brucei relies on interactions between different skeletal structures in the flagellum and cell body

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30 Aug 2013
publication

Molecular basis of tubulin transport within the cilium by IFT74 and IFT81

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21 Dec 2012
publication

Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani

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26 Oct 2012
publication

Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms

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19 Sep 2012
publication

Intraflagellar transport proteins cycle between the flagellum and its base

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04 Apr 2012
publication

A new asymmetric division contributes to the continuous production of infective trypanosomes in the tsetse fly

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27 Mar 2012
publication

NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions

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30 Sep 2011
publication

ALBA proteins are stage regulated during trypanosome development in the tsetse fly and participate in differentiation

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26 Apr 2011
publication

Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation

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19 Apr 2011
publication

[The importance of model organisms to study cilia and flagella biology]

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01 Mar 2011
publication

The ciliary pocket: a once-forgotten membrane domain at the base of cilia

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01 Mar 2011
publication

1001 model organisms to study cilia and flagella

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18 Jan 2011
publication

Molecular bases of cytoskeleton plasticity during the Trypanosoma brucei parasite cycle

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29 Jun 2010
publication

Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability

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25 Jun 2010
publication

The peculiarities of flagella in parasitic protozoa

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27 Apr 2010
publication

The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia

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04 Dec 2009
publication

Tools for analyzing intraflagellar transport in trypanosomes

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01 Dec 2009
publication

Loss-of-function mutations in the human ortholog of Chlamydomonas reinhardtii ODA7 disrupt dynein arm assembly and cause primary ciliary dyskinesia

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23 Nov 2009
publication

Kinesin 9 family members perform separate functions in the trypanosome flagellum

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24 Feb 2009
publication

A novel function for the atypical small G protein Rab-like 5 in the assembly of the trypanosome flagellum

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04 Feb 2009
publication

The flagellum-mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development?

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21 Oct 2008
publication

Flagellum elongation is required for correct structure, orientation and function of the flagellar pocket in Trypanosoma brucei

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19 Dec 2007
publication

Intraflagellar transport and functional analysis of genes required for flagellum formation in trypanosomes

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01 Aug 2007
publication

The Argonaute protein TbAGO1 contributes to large and mini-chromosome segregation and is required for control of RIME retroposons and RHS pseudogene-associated transcripts

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09 May 2007
publication

Basal body positioning is controlled by flagellum formation in Trypanosoma brucei

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01 Aug 2006
publication

Conserved and specific functions of axoneme components in trypanosome motility

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09 Feb 2005
publication

Functional complementation of RNA interference mutants in trypanosomes

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01 Jan 2005
publication

The flagellum of trypanosomes

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12 Dec 2003
publication

TbAGO1, an argonaute protein required for RNA interference, is involved in mitosis and chromosome segregation in Trypanosoma brucei

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15 Oct 2003
publication

Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes

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01 Jun 2003
publication

Efficiency and specificity of RNA interference generated by intra- and intermolecular double stranded RNA in Trypanosoma brucei

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01 Jan 2003
publication

[The flagellum: from cell motility to morphogenesis]

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01 Mar 2001
publication

Genetic interference in protozoa

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01 Dec 2000
publication

Inside and outside of the trypanosome flagellum:a multifunctional organelle

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01 Sep 2000
publication

Flagellum ontogeny in trypanosomes studied via an inherited and regulated RNA interference system

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01 Dec 1999
publication

Flagellar morphogenesis: protein targeting and assembly in the paraflagellar rod of trypanosomes

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01 Nov 1999
publication

Protein transport and flagellum assembly dynamics revealed by analysis of the paralysed trypanosome mutant snl-1

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01 Aug 1999
publication

Assembly and function of complex flagellar structures illustrated by the paraflagellar rod of trypanosomes

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01 Feb 1998
publication

Paraflagellar rod is vital for trypanosome motility

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01 Dec 1997
publication

A motility function for the paraflagellar rod of Leishmania parasites revealed by PFR-2 gene knockouts

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01 Aug 1996
publication

The paraflagellar rod of kinetoplastida: solved and unsolved questions

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01 May 1996
publication

A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei

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01 Feb 1996
publication

An M(r) 145,000 low-density lipoprotein (LDL)-binding protein is conserved throughout the Kinetoplastida order

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01 Jan 1995
publication

Activity, pharmacological inhibition and biological regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Trypanosoma brucei

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01 Feb 1994
publication

Identification of a specific epitope on the extracellular domain of the LDL-receptor of Trypanosoma brucei brucei

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01 Feb 1992
publication

Trypanosoma brucei brucei: antigenic stability of its LDL receptor and immunological cross-reactivity with the LDL receptor of the mammalian host

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15 Jul 1991
publication

A rapid method purifies a glycoprotein of Mr 145,000 as the LDL receptor of Trypanosoma brucei brucei

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