Timeline
Andres Alcover
Head of Structure
19 Jul 2024
project
Effet des mutations du gène Adenomatous polyposis coli (APC) dans la réponse immune antitumorale « Pro4TCan ».
Read more05 Mar 2024
publication
Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids
Read more18 Jul 2023
publication
T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations
Read more15 Apr 2022
news
New publication – The tumor suppressor Adenomatous polyposis coli regulates T lymphocyte migration
Read more15 Apr 2022
publication
The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration.
Read more06 Oct 2021
publication
Cell Polarity Regulators, Multifunctional Organizers of Lymphocyte Activation and Function.
Read more21 Oct 2020
publication
Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions.
Read more24 Jun 2020
publication
Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions.
Read more10 Mar 2020
publication
ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation.
Read more15 Nov 2019
event
Department of Immunology seminar: « Florence, Niedergang, When viral infection of macrophages promotes bacterial super-infections »
Read more07 Mar 2019
project
Projet de Recherche Clinique : Impact des mutations du gène APC (Adenomatous polyposis coli) dans les réponses immunes anti-tumorales
Read more12 Oct 2018
project
CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie
Read more03 Oct 2018
publication
HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton-Mediated T Cell Functions.
Read more26 Apr 2018
07 Oct 2017
news
Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization
Read more03 Oct 2017
publication
Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization.
Read more01 Jan 2017
01 Jan 2017
17 Aug 2016
publication
The functional interplay of Rab11, FIP3 and Rho proteins on the endosomal recycling pathway controls cell shape and symmetry
Read more22 Jun 2016
07 Jul 2015
project
How the dynamics of signaling complexes at the immunological synapse controls T cell activation
Read more06 Jul 2015
project
Cytoskeleton, immunological synapse and T cell activation: role of Ezrin and Adenomatous polyposis coli
Read more01 Jun 2015
05 May 2015
publication
Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype
Read more11 Jul 2014
01 Nov 2013
publication
Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses
Read more07 Oct 2013
publication
Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse
Read more09 Oct 2012
publication
Microtubule dynamics and signal transduction at the immunological synapse: new partners and new connections
Read more21 Nov 2011
publication
Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.
Read more31 Mar 2011
07 Sep 2010
01 Jan 2010
publication
Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses
Read more20 Dec 2009
publication
Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses
Read more24 Mar 2007
01 May 2006
publication
Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse
Read more01 May 2006
publication
Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarization, immune synapse formation and in T cell receptor-mediated signaling
Read more19 Apr 2005
30 Jun 2004
publication
Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment
Read more01 May 2004
publication
Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes
Read more18 Dec 2003
publication
Characterization of a gene encoding two isoforms of a mitochondrial protein up-regulated by cyclosporin A in activated T cells
Read more01 Feb 2003
01 Jan 2003
publication
T-lymphocyte activation induced by staphylococcal enterotoxin superantigens. Analysis of protein tyrosine phosphorylation
Read more01 Jan 2003
publication
Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor
Read more01 Nov 2002
publication
Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation
Read more16 Oct 2002
publication
Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways
Read more01 Sep 2002
publication
Defective assembly of the B-cell receptor chains accounts for its low expression in B-chronic lymphocytic leukaemia
Read more07 Jan 2002
01 Dec 2000
publication
Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner
Read more01 Oct 2000
01 Aug 2000
publication
Dissection of the role of CD3gamma chains in profound but reversible T-cell receptor down-regulation
Read more24 Jun 2000
publication
Convulxin binding to platelet receptor GPVI: competition with collagen related peptides
Read more01 Feb 2000
publication
Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism
Read more01 Jan 2000
01 Jul 1999
01 Dec 1998
15 Aug 1997
publication
Peptide antigen or superantigen-induced down-regulation of TCRs involves both stimulated and unstimulated receptors
Read more01 May 1997
publication
Differential cytosolic tail dependence and intracellular fate of T-cell receptors internalized upon activation with superantigen or phorbol ester
Read more26 Jul 1996
publication
An activated epidermal growth factor receptor/Lck chimera restores early T cell receptor-mediated calcium response in a CD45-deficient T cell line
Read more01 Apr 1996
publication
Combination of human cytomegalovirus recombinant immediate-early protein (IE1) with 80 nm cationic biovectors: protection from proteolysis and potentiation of presentation to CD4+ T-cell clones in vitro
Read more26 May 1995
publication
The Staphylococcus aureus enterotoxin B superantigen induces specific T cell receptor down-regulation by increasing its internalization
Read more01 Oct 1994
publication
Jacalin, a lectin that inhibits in vitro HIV-1 infection, induces intracellular calcium increase via CD4 in cells lacking the CD3/TcR complex
Read more25 Jan 1993
publication
Evidence for an extended structure of the T-cell co-receptor CD8 alpha as deduced from the hydrodynamic properties of soluble forms of the extracellular region
Read more01 Jan 1993
publication
A soluble form of the human CD8 alpha chain expressed in the baculovirus system: biochemical characterization and binding to MHC class I
Read more01 Nov 1992
publication
Both T cell receptor (TcR)-CD3 complex and CD2 increase the tyrosine kinase activity of p56lck. CD2 can mediate TcR-CD3-independent and CD45-dependent activation of p56lck
Read more01 Feb 1992
publication
Engagement of major histocompatibility complex class I and class II molecules up-regulates intercellular adhesion of human B cells via a CD11/CD18-independent mechanism
Read more01 Aug 1991
publication
The tyrosine kinase activity of p56lck is increased in human T cells activated via CD2
Read more01 Jul 1990
publication
Characterization of functional GTP binding proteins in Jurkat T cell mutants lacking either CD3-Ti or CD2 surface receptors
Read more05 Mar 1990
publication
Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization
Read more01 Dec 1989
publication
The lymphocyte-specific protein tyrosine kinase p56lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2
Read more01 Oct 1989
01 Sep 1989
publication
CD3Ti+ human thymocyte-derived clones displaying a differential response to activation via CD3Ti and CD2
Read more15 Jan 1989
publication
Triggering of T-lymphocytes via either T3-Ti or T11 surface structures opens a voltage-insensitive plasma membrane calcium-permeable channel: requirement for interleukin-2 gene function
Read more01 Dec 1988
publication
Expression of a functional CD3-Ti antigen/MHC receptor in the absence of surface CD2. Analysis with clonal Jurkat cell mutants
Read more01 Jul 1988
01 Mar 1988
publication
The T 11 (CD 2) cDNA encodes a transmembrane protein which expresses T 11(1), T 11(2) and T 11(3) epitopes but which does not independently mediate calcium influx: analysis by gene transfer in a baculovirus system
Read more01 Jul 1987
publication
Ion channels activated by specific Ti or T3 antibodies in plasma membranes of human T cells
Read more01 Feb 1987
publication
Functional and molecular aspects of human T lymphocyte activation via T3-Ti and T11 pathways
Read more01 Apr 1986
publication
The T11 glycoprotein is functionally linked to a calcium channel in precursor and mature T-lineage cells
Read more01 Jul 1985
publication
Human vimentin autoantibodies preferentially interact with a peptide of 30kD mol. wt, located close to the amino-terminal of the molecule
Read more01 Apr 1985
publication
Antibodies to vimentin intermediate filaments in sera from patients with SLE and RA: quantitation by solid phase radioimmunoassay
Read more01 Aug 1984
publication
Antibodies to vimentin intermediate filaments in sera from patients with systemic lupus erythematosus
Read more01 Jan 1982
publication
In situ immunofluorescent visualization of chromosomal transcripts in polytene chromosomes
Read more01 Dec 1981
publication