Timeline

Andres Alcover
Head of Structure
07 Mar 2019
project

Projet de Recherche Clinique : Impact des mutations du gène APC (Adenomatous polyposis coli) dans les réponses immunes anti-tumorales

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13 Feb 2019
team

Immunomodulation and infection

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30 Oct 2018
news

Recrutement de patients atteints de polypose familiale porteurs de mutation du gène APC

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12 Oct 2018
project

CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie

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03 Oct 2018
publication

HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton-Mediated T Cell Functions

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20 Dec 2017
publication

Cell Biology of T Cell Receptor Expression and Regulation

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07 Oct 2017
news

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization

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03 Oct 2017
publication

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization

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24 Feb 2017
publication

Rab11-FIP3 Regulation of Lck Endosomal Traffic Controls TCR Signal Transduction

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20 Jan 2017
publication

Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function

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01 Jan 2017
publication

Studying the Immune Synapse in HIV-1 Infection

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01 Jan 2017
publication

Imaging Vesicular Traffic at the Immune Synapse

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17 Aug 2016
publication

The functional interplay of Rab11, FIP3 and Rho proteins on the endosomal recycling pathway controls cell shape and symmetry

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22 Jun 2016
project

Think tank: Cancer

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06 May 2016
publication

Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation

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07 Jul 2015
project

The “virus biofilm”: a new mode of virus cell-to-cell transmission

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07 Jul 2015
project

Intracellular vesicle traffic drives immunological synapse formation and T cell activation. Modulation by human immunodeficiency virus (HIV-1)

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07 Jul 2015
project

How the dynamics of signaling complexes at the immunological synapse controls T cell activation

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06 Jul 2015
project

Cytoskeleton, immunological synapse and T cell activation: role of Ezrin and Adenomatous polyposis coli

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01 Jun 2015
publication

Immunological Synapse

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11 May 2015
team

Lymphocyte Cell Biology

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05 May 2015
publication

Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype

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11 Jul 2014
publication

[Immunological synapse is a dynamic signaling platform for T cell activation]

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01 Nov 2013
publication

Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses

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07 Oct 2013
publication

Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse

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09 Oct 2012
publication

Microtubule dynamics and signal transduction at the immunological synapse: new partners and new connections

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21 Nov 2011
publication

Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation

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31 Mar 2011
publication

Can viruses form biofilms?

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07 Sep 2010
publication

Cytoskeletal cross-talk in the control of T cell antigen receptor signaling

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15 Jun 2010
publication

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse

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01 Jan 2010
publication

Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses

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20 Dec 2009
publication

Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses

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24 Mar 2007
publication

Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

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11 Jan 2007
publication

ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation

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01 May 2006
publication

Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse

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01 May 2006
publication

Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarization, immune synapse formation and in T cell receptor-mediated signaling

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19 Apr 2005
publication

ARF6 GTPase controls bacterial invasion by actin remodelling

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30 Jun 2004
publication

Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment

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01 May 2004
publication

Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes

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18 Dec 2003
publication

Characterization of a gene encoding two isoforms of a mitochondrial protein up-regulated by cyclosporin A in activated T cells

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01 Feb 2003
publication

The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression

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01 Jan 2003
publication

T-lymphocyte activation induced by staphylococcal enterotoxin superantigens. Analysis of protein tyrosine phosphorylation

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01 Jan 2003
publication

Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor

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01 Nov 2002
publication

Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation

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16 Oct 2002
publication

Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways

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01 Sep 2002
publication

Defective assembly of the B-cell receptor chains accounts for its low expression in B-chronic lymphocytic leukaemia

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07 Jan 2002
publication

Role of ICAM-3 in the initial interaction of T lymphocytes and APCs

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01 Nov 2001
publication

The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation

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01 Dec 2000
publication

Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner

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01 Oct 2000
publication

CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation

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01 Aug 2000
publication

Dissection of the role of CD3gamma chains in profound but reversible T-cell receptor down-regulation

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24 Jun 2000
publication

Convulxin binding to platelet receptor GPVI: competition with collagen related peptides

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01 Feb 2000
publication

Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism

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01 Jan 2000
publication

Internalization and intracellular fate of TCR-CD3 complexes

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01 Jul 1999
publication

The CD3 epsilon subunit of the TCR contains endocytosis signals

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01 Dec 1998
publication

Cooperative activation of TCRs by enterotoxin superantigens

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15 Aug 1997
publication

Peptide antigen or superantigen-induced down-regulation of TCRs involves both stimulated and unstimulated receptors

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01 May 1997
publication

Differential cytosolic tail dependence and intracellular fate of T-cell receptors internalized upon activation with superantigen or phorbol ester

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26 Jul 1996
publication

An activated epidermal growth factor receptor/Lck chimera restores early T cell receptor-mediated calcium response in a CD45-deficient T cell line

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01 Apr 1996
publication

Combination of human cytomegalovirus recombinant immediate-early protein (IE1) with 80 nm cationic biovectors: protection from proteolysis and potentiation of presentation to CD4+ T-cell clones in vitro

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26 May 1995
publication

The Staphylococcus aureus enterotoxin B superantigen induces specific T cell receptor down-regulation by increasing its internalization

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01 Oct 1994
publication

Jacalin, a lectin that inhibits in vitro HIV-1 infection, induces intracellular calcium increase via CD4 in cells lacking the CD3/TcR complex

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25 Jan 1993
publication

Evidence for an extended structure of the T-cell co-receptor CD8 alpha as deduced from the hydrodynamic properties of soluble forms of the extracellular region

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01 Jan 1993
publication

A soluble form of the human CD8 alpha chain expressed in the baculovirus system: biochemical characterization and binding to MHC class I

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01 Nov 1992
publication

Both T cell receptor (TcR)-CD3 complex and CD2 increase the tyrosine kinase activity of p56lck. CD2 can mediate TcR-CD3-independent and CD45-dependent activation of p56lck

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01 Feb 1992
publication

Engagement of major histocompatibility complex class I and class II molecules up-regulates intercellular adhesion of human B cells via a CD11/CD18-independent mechanism

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01 Aug 1991
publication

The tyrosine kinase activity of p56lck is increased in human T cells activated via CD2

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01 Jul 1990
publication

Characterization of functional GTP binding proteins in Jurkat T cell mutants lacking either CD3-Ti or CD2 surface receptors

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05 Mar 1990
publication

Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization

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01 Dec 1989
publication

The lymphocyte-specific protein tyrosine kinase p56lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2

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01 Oct 1989
publication

The structural biology of CD2

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01 Sep 1989
publication

CD3Ti+ human thymocyte-derived clones displaying a differential response to activation via CD3Ti and CD2

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15 Jan 1989
publication

Triggering of T-lymphocytes via either T3-Ti or T11 surface structures opens a voltage-insensitive plasma membrane calcium-permeable channel: requirement for interleukin-2 gene function

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01 Dec 1988
publication

Expression of a functional CD3-Ti antigen/MHC receptor in the absence of surface CD2. Analysis with clonal Jurkat cell mutants

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01 Jul 1988
publication

Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes

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01 Mar 1988
publication

The T 11 (CD 2) cDNA encodes a transmembrane protein which expresses T 11(1), T 11(2) and T 11(3) epitopes but which does not independently mediate calcium influx: analysis by gene transfer in a baculovirus system

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01 Jul 1987
publication

Ion channels activated by specific Ti or T3 antibodies in plasma membranes of human T cells

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01 Feb 1987
publication

Functional and molecular aspects of human T lymphocyte activation via T3-Ti and T11 pathways

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01 Apr 1986
publication

The T11 glycoprotein is functionally linked to a calcium channel in precursor and mature T-lineage cells

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01 Jul 1985
publication

Human vimentin autoantibodies preferentially interact with a peptide of 30kD mol. wt, located close to the amino-terminal of the molecule

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01 Apr 1985
publication

Antibodies to vimentin intermediate filaments in sera from patients with SLE and RA: quantitation by solid phase radioimmunoassay

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01 Aug 1984
publication

Antibodies to vimentin intermediate filaments in sera from patients with systemic lupus erythematosus

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01 Jan 1982
publication

In situ immunofluorescent visualization of chromosomal transcripts in polytene chromosomes

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01 Dec 1981
publication

Analytical studies of chromosomal transcription detected by an endogenous hybridization technique (EHT) using autoradiography and indirect immunofluorescence in Drosophila hydei

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