Timeline

Andres Alcover
Head of Structure
19 Jul 2024
project

Effet des mutations du gène Adenomatous polyposis coli (APC) dans la réponse immune antitumorale « Pro4TCan ».

Read more
05 Mar 2024
publication

Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids

Read more
18 Jul 2023
publication

T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations

Read more
15 Apr 2022
news

New publication – The tumor suppressor Adenomatous polyposis coli regulates T lymphocyte migration

Read more
15 Apr 2022
publication

The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration.

Read more
06 Oct 2021
publication

Cell Polarity Regulators, Multifunctional Organizers of Lymphocyte Activation and Function.

Read more
21 Oct 2020
publication

Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions.

Read more
24 Jun 2020
publication

Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions.

Read more
10 Mar 2020
publication

ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation.

Read more
15 Nov 2019
event

Department of Immunology seminar: « Florence, Niedergang, When viral infection of macrophages promotes bacterial super-infections »

Read more
07 Mar 2019
project

Projet de Recherche Clinique : Impact des mutations du gène APC (Adenomatous polyposis coli) dans les réponses immunes anti-tumorales

Read more
12 Oct 2018
project

CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie

Read more
03 Oct 2018
publication

HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton-Mediated T Cell Functions.

Read more
26 Apr 2018
publication

Cell Biology of T Cell Receptor Expression and Regulation.

Read more
07 Oct 2017
news

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization

Read more
03 Oct 2017
publication

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization.

Read more
01 Jan 2017
publication

Studying the Immune Synapse in HIV-1 Infection

Read more
01 Jan 2017
publication

Imaging Vesicular Traffic at the Immune Synapse

Read more
17 Aug 2016
publication

The functional interplay of Rab11, FIP3 and Rho proteins on the endosomal recycling pathway controls cell shape and symmetry

Read more
22 Jun 2016
project

Think tank: Cancer

Read more
07 Jul 2015
project

How the dynamics of signaling complexes at the immunological synapse controls T cell activation

Read more
06 Jul 2015
project

Cytoskeleton, immunological synapse and T cell activation: role of Ezrin and Adenomatous polyposis coli

Read more
01 Jun 2015
publication

Immunological Synapse

Read more
05 May 2015
publication

Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype

Read more
11 Jul 2014
publication

[Immunological synapse is a dynamic signaling platform for T cell activation]

Read more
01 Nov 2013
publication

Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses

Read more
07 Oct 2013
publication

Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse

Read more
09 Oct 2012
publication

Microtubule dynamics and signal transduction at the immunological synapse: new partners and new connections

Read more
21 Nov 2011
publication

Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.

Read more
31 Mar 2011
publication

Can viruses form biofilms?

Read more
07 Sep 2010
publication

Cytoskeletal cross-talk in the control of T cell antigen receptor signaling

Read more
01 Jan 2010
publication

Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses

Read more
20 Dec 2009
publication

Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses

Read more
24 Mar 2007
publication

Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

Read more
01 May 2006
publication

Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse

Read more
01 May 2006
publication

Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarization, immune synapse formation and in T cell receptor-mediated signaling

Read more
19 Apr 2005
publication

ARF6 GTPase controls bacterial invasion by actin remodelling

Read more
30 Jun 2004
publication

Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment

Read more
01 May 2004
publication

Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes

Read more
18 Dec 2003
publication

Characterization of a gene encoding two isoforms of a mitochondrial protein up-regulated by cyclosporin A in activated T cells

Read more
01 Feb 2003
publication

The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression

Read more
01 Jan 2003
publication

T-lymphocyte activation induced by staphylococcal enterotoxin superantigens. Analysis of protein tyrosine phosphorylation

Read more
01 Jan 2003
publication

Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor

Read more
01 Nov 2002
publication

Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation

Read more
16 Oct 2002
publication

Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways

Read more
01 Sep 2002
publication

Defective assembly of the B-cell receptor chains accounts for its low expression in B-chronic lymphocytic leukaemia

Read more
07 Jan 2002
publication

Role of ICAM-3 in the initial interaction of T lymphocytes and APCs

Read more
01 Dec 2000
publication

Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner

Read more
01 Oct 2000
publication

CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation.

Read more
01 Aug 2000
publication

Dissection of the role of CD3gamma chains in profound but reversible T-cell receptor down-regulation

Read more
24 Jun 2000
publication

Convulxin binding to platelet receptor GPVI: competition with collagen related peptides

Read more
01 Feb 2000
publication

Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism

Read more
01 Jan 2000
publication

Internalization and intracellular fate of TCR-CD3 complexes

Read more
01 Jul 1999
publication

The CD3 epsilon subunit of the TCR contains endocytosis signals

Read more
01 Dec 1998
publication

Cooperative activation of TCRs by enterotoxin superantigens

Read more
15 Aug 1997
publication

Peptide antigen or superantigen-induced down-regulation of TCRs involves both stimulated and unstimulated receptors

Read more
01 May 1997
publication

Differential cytosolic tail dependence and intracellular fate of T-cell receptors internalized upon activation with superantigen or phorbol ester

Read more
26 Jul 1996
publication

An activated epidermal growth factor receptor/Lck chimera restores early T cell receptor-mediated calcium response in a CD45-deficient T cell line

Read more
01 Apr 1996
publication

Combination of human cytomegalovirus recombinant immediate-early protein (IE1) with 80 nm cationic biovectors: protection from proteolysis and potentiation of presentation to CD4+ T-cell clones in vitro

Read more
26 May 1995
publication

The Staphylococcus aureus enterotoxin B superantigen induces specific T cell receptor down-regulation by increasing its internalization

Read more
01 Oct 1994
publication

Jacalin, a lectin that inhibits in vitro HIV-1 infection, induces intracellular calcium increase via CD4 in cells lacking the CD3/TcR complex

Read more
25 Jan 1993
publication

Evidence for an extended structure of the T-cell co-receptor CD8 alpha as deduced from the hydrodynamic properties of soluble forms of the extracellular region

Read more
01 Jan 1993
publication

A soluble form of the human CD8 alpha chain expressed in the baculovirus system: biochemical characterization and binding to MHC class I

Read more
01 Nov 1992
publication

Both T cell receptor (TcR)-CD3 complex and CD2 increase the tyrosine kinase activity of p56lck. CD2 can mediate TcR-CD3-independent and CD45-dependent activation of p56lck

Read more
01 Feb 1992
publication

Engagement of major histocompatibility complex class I and class II molecules up-regulates intercellular adhesion of human B cells via a CD11/CD18-independent mechanism

Read more
01 Aug 1991
publication

The tyrosine kinase activity of p56lck is increased in human T cells activated via CD2

Read more
01 Jul 1990
publication

Characterization of functional GTP binding proteins in Jurkat T cell mutants lacking either CD3-Ti or CD2 surface receptors

Read more
05 Mar 1990
publication

Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization

Read more
01 Dec 1989
publication

The lymphocyte-specific protein tyrosine kinase p56lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2

Read more
01 Oct 1989
publication

The structural biology of CD2

Read more
01 Sep 1989
publication

CD3Ti+ human thymocyte-derived clones displaying a differential response to activation via CD3Ti and CD2

Read more
15 Jan 1989
publication

Triggering of T-lymphocytes via either T3-Ti or T11 surface structures opens a voltage-insensitive plasma membrane calcium-permeable channel: requirement for interleukin-2 gene function

Read more
01 Dec 1988
publication

Expression of a functional CD3-Ti antigen/MHC receptor in the absence of surface CD2. Analysis with clonal Jurkat cell mutants

Read more
01 Jul 1988
publication

Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes

Read more
01 Mar 1988
publication

The T 11 (CD 2) cDNA encodes a transmembrane protein which expresses T 11(1), T 11(2) and T 11(3) epitopes but which does not independently mediate calcium influx: analysis by gene transfer in a baculovirus system

Read more
01 Jul 1987
publication

Ion channels activated by specific Ti or T3 antibodies in plasma membranes of human T cells

Read more
01 Feb 1987
publication

Functional and molecular aspects of human T lymphocyte activation via T3-Ti and T11 pathways

Read more
01 Apr 1986
publication

The T11 glycoprotein is functionally linked to a calcium channel in precursor and mature T-lineage cells

Read more
01 Jul 1985
publication

Human vimentin autoantibodies preferentially interact with a peptide of 30kD mol. wt, located close to the amino-terminal of the molecule

Read more
01 Apr 1985
publication

Antibodies to vimentin intermediate filaments in sera from patients with SLE and RA: quantitation by solid phase radioimmunoassay

Read more
01 Aug 1984
publication

Antibodies to vimentin intermediate filaments in sera from patients with systemic lupus erythematosus

Read more
01 Jan 1982
publication

In situ immunofluorescent visualization of chromosomal transcripts in polytene chromosomes

Read more
01 Dec 1981
publication

Analytical studies of chromosomal transcription detected by an endogenous hybridization technique (EHT) using autoradiography and indirect immunofluorescence in Drosophila hydei

Read more