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© Andres Alcover
Scanning electron microscopy showing a conjugate formed between a T lymphocyte and an antigen presenting cell. It is worth noting the long shape of the T cell (Tc) polarized towards the antigen presenting cell (APC) and the membrane protrusions that adhere the T lymphocyte to the antigen presenting cell.
Publication : The EMBO journal

Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes

Team: Archived: Lymphocyte Cell Biology
Member: Andres Alcover
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The EMBO journal - 01 Jul 1988

Alcover A, Alberini C, Acuto O, Clayton LK, Transy C, Spagnoli GC, Moingeon P, Lopez P, Reinherz EL

Link to Pubmed [PMID] – 2901344

EMBO J. 1988 Jul;7(7):1973-7

Human T lymphocytes can be activated through either the antigen/MHC receptor complex T3-Ti (CD3-Ti) or the T11 (CD2) molecule to proliferate via an IL-2 dependent mechanism. To investigate the relationship of these pathways to one another, we generated and characterized Jurkat mutants which selectively express either surface CD3-Ti or CD2. Here we show that CD3-Ti- mutants fail to be stimulated by either pathway to increase phosphoinositide turnover, mobilize calcium or induce the IL-2 gene. The activation capacity of these mutants via CD2 as well as CD3-Ti can be restored following reconstitution of surface CD3-Ti expression upon appropriate DNA transfer (e.g. Ti beta subunit cDNA into Ti beta- Jurkat variants). Collectively, these results demonstrate that CD3-Ti and CD2 pathways are interdependent and that phosphoinositide turnover is linked to the CD3-Ti complex.