Ligne de temps
Andres Alcover
Responsable de Structure
05 mars 2024
publication
Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids
Lire plus18 juil. 2023
publication
T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations
Lire plus15 avr. 2022
news
New publication – The tumor suppressor Adenomatous polyposis coli regulates T lymphocyte migration
Lire plus15 avr. 2022
publication
The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration.
Lire plus06 oct. 2021
publication
Cell Polarity Regulators, Multifunctional Organizers of Lymphocyte Activation and Function.
Lire plus21 oct. 2020
publication
Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions.
Lire plus24 juin 2020
publication
Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions.
Lire plus10 mars 2020
publication
ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation.
Lire plus15 nov. 2019
event
Department of Immunology seminar: « Florence, Niedergang, When viral infection of macrophages promotes bacterial super-infections »
Lire plus07 mars 2019
project
Projet de Recherche Clinique : Impact des mutations du gène APC (Adenomatous polyposis coli) dans les réponses immunes anti-tumorales
Lire plus12 oct. 2018
project
CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie
Lire plus03 oct. 2018
publication
HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton-Mediated T Cell Functions.
Lire plus26 avr. 2018
07 oct. 2017
news
Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization
Lire plus03 oct. 2017
publication
Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization.
Lire plus01 janv. 2017
01 janv. 2017
17 août 2016
publication
The functional interplay of Rab11, FIP3 and Rho proteins on the endosomal recycling pathway controls cell shape and symmetry
Lire plus22 juin 2016
07 juil. 2015
project
How the dynamics of signaling complexes at the immunological synapse controls T cell activation
Lire plus06 juil. 2015
project
Cytoskeleton, immunological synapse and T cell activation: role of Ezrin and Adenomatous polyposis coli
Lire plus01 juin 2015
05 mai 2015
publication
Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype
Lire plus11 juil. 2014
01 nov. 2013
publication
Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses
Lire plus07 oct. 2013
publication
Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse
Lire plus09 oct. 2012
publication
Microtubule dynamics and signal transduction at the immunological synapse: new partners and new connections
Lire plus21 nov. 2011
publication
Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.
Lire plus31 mars 2011
07 sept. 2010
01 janv. 2010
publication
Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses
Lire plus20 déc. 2009
publication
Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses
Lire plus24 mars 2007
01 mai 2006
publication
Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse
Lire plus01 mai 2006
publication
Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarization, immune synapse formation and in T cell receptor-mediated signaling
Lire plus19 avr. 2005
30 juin 2004
publication
Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment
Lire plus01 mai 2004
publication
Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes
Lire plus18 déc. 2003
publication
Characterization of a gene encoding two isoforms of a mitochondrial protein up-regulated by cyclosporin A in activated T cells
Lire plus01 févr. 2003
01 janv. 2003
publication
T-lymphocyte activation induced by staphylococcal enterotoxin superantigens. Analysis of protein tyrosine phosphorylation
Lire plus01 janv. 2003
publication
Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor
Lire plus01 nov. 2002
publication
Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation
Lire plus16 oct. 2002
publication
Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways
Lire plus01 sept. 2002
publication
Defective assembly of the B-cell receptor chains accounts for its low expression in B-chronic lymphocytic leukaemia
Lire plus07 janv. 2002
01 déc. 2000
publication
Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner
Lire plus01 oct. 2000
01 août 2000
publication
Dissection of the role of CD3gamma chains in profound but reversible T-cell receptor down-regulation
Lire plus24 juin 2000
publication
Convulxin binding to platelet receptor GPVI: competition with collagen related peptides
Lire plus01 févr. 2000
publication
Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism
Lire plus01 janv. 2000
01 juil. 1999
01 déc. 1998
15 août 1997
publication
Peptide antigen or superantigen-induced down-regulation of TCRs involves both stimulated and unstimulated receptors
Lire plus01 mai 1997
publication
Differential cytosolic tail dependence and intracellular fate of T-cell receptors internalized upon activation with superantigen or phorbol ester
Lire plus26 juil. 1996
publication
An activated epidermal growth factor receptor/Lck chimera restores early T cell receptor-mediated calcium response in a CD45-deficient T cell line
Lire plus01 avr. 1996
publication
Combination of human cytomegalovirus recombinant immediate-early protein (IE1) with 80 nm cationic biovectors: protection from proteolysis and potentiation of presentation to CD4+ T-cell clones in vitro
Lire plus26 mai 1995
publication
The Staphylococcus aureus enterotoxin B superantigen induces specific T cell receptor down-regulation by increasing its internalization
Lire plus01 oct. 1994
publication
Jacalin, a lectin that inhibits in vitro HIV-1 infection, induces intracellular calcium increase via CD4 in cells lacking the CD3/TcR complex
Lire plus25 janv. 1993
publication
Evidence for an extended structure of the T-cell co-receptor CD8 alpha as deduced from the hydrodynamic properties of soluble forms of the extracellular region
Lire plus01 janv. 1993
publication
A soluble form of the human CD8 alpha chain expressed in the baculovirus system: biochemical characterization and binding to MHC class I
Lire plus01 nov. 1992
publication
Both T cell receptor (TcR)-CD3 complex and CD2 increase the tyrosine kinase activity of p56lck. CD2 can mediate TcR-CD3-independent and CD45-dependent activation of p56lck
Lire plus01 févr. 1992
publication
Engagement of major histocompatibility complex class I and class II molecules up-regulates intercellular adhesion of human B cells via a CD11/CD18-independent mechanism
Lire plus01 août 1991
publication
The tyrosine kinase activity of p56lck is increased in human T cells activated via CD2
Lire plus01 juil. 1990
publication
Characterization of functional GTP binding proteins in Jurkat T cell mutants lacking either CD3-Ti or CD2 surface receptors
Lire plus05 mars 1990
publication
Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization
Lire plus01 déc. 1989
publication
The lymphocyte-specific protein tyrosine kinase p56lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2
Lire plus01 oct. 1989
01 sept. 1989
publication
CD3Ti+ human thymocyte-derived clones displaying a differential response to activation via CD3Ti and CD2
Lire plus15 janv. 1989
publication
Triggering of T-lymphocytes via either T3-Ti or T11 surface structures opens a voltage-insensitive plasma membrane calcium-permeable channel: requirement for interleukin-2 gene function
Lire plus01 déc. 1988
publication
Expression of a functional CD3-Ti antigen/MHC receptor in the absence of surface CD2. Analysis with clonal Jurkat cell mutants
Lire plus01 juil. 1988
01 mars 1988
publication
The T 11 (CD 2) cDNA encodes a transmembrane protein which expresses T 11(1), T 11(2) and T 11(3) epitopes but which does not independently mediate calcium influx: analysis by gene transfer in a baculovirus system
Lire plus01 juil. 1987
publication
Ion channels activated by specific Ti or T3 antibodies in plasma membranes of human T cells
Lire plus01 févr. 1987
publication
Functional and molecular aspects of human T lymphocyte activation via T3-Ti and T11 pathways
Lire plus01 avr. 1986
publication
The T11 glycoprotein is functionally linked to a calcium channel in precursor and mature T-lineage cells
Lire plus01 juil. 1985
publication
Human vimentin autoantibodies preferentially interact with a peptide of 30kD mol. wt, located close to the amino-terminal of the molecule
Lire plus01 avr. 1985
publication
Antibodies to vimentin intermediate filaments in sera from patients with SLE and RA: quantitation by solid phase radioimmunoassay
Lire plus01 août 1984
publication
Antibodies to vimentin intermediate filaments in sera from patients with systemic lupus erythematosus
Lire plus01 janv. 1982
publication
In situ immunofluorescent visualization of chromosomal transcripts in polytene chromosomes
Lire plus01 déc. 1981
publication