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© Andres Alcover
Scanning electron microscopy showing a conjugate formed between a T lymphocyte and an antigen presenting cell. It is worth noting the long shape of the T cell (Tc) polarized towards the antigen presenting cell (APC) and the membrane protrusions that adhere the T lymphocyte to the antigen presenting cell.
Publication : Journal of leukocyte biology

Jacalin, a lectin that inhibits in vitro HIV-1 infection, induces intracellular calcium increase via CD4 in cells lacking the CD3/TcR complex

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of leukocyte biology - 01 Oct 1994

Lafont V, Dornand J, d'Angeac AD, Monier S, Alcover A, Favero J

Link to Pubmed [PMID] – 7930950

J. Leukoc. Biol. 1994 Oct;56(4):521-4

The lectin jacalin interacts with the CD4 cell surface antigen; this lectin inhibits in vitro infection by human immunodeficiency virus type 1 without preventing virus binding on the host cell. The infection process is known to involve cellular events triggered by the binding of the viral external glycoprotein gp120 to CD4. Herein we demonstrate that jacalin induces cell signaling directly through the CD4 antigen and that independently of the CD3/TcR complex. The capacity of jacalin to trigger cell signals through the CD4 molecule is discussed in relation to its ability to inhibit HIV infection.

https://www.ncbi.nlm.nih.gov/pubmed/7930950