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© Andres Alcover
Scanning electron microscopy showing a conjugate formed between a T lymphocyte and an antigen presenting cell. It is worth noting the long shape of the T cell (Tc) polarized towards the antigen presenting cell (APC) and the membrane protrusions that adhere the T lymphocyte to the antigen presenting cell.
Publication : Nature Review Immunology

Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature Review Immunology - 24 Mar 2007

Fackler OT, Alcover A, Schwartz O

Link to Pubmed [PMID] – 17380160

Nat Rev Immunol. 2007 Apr;7(4):310-7

AIDS is the result of a constant struggle between the lentivirus HIV and the immune system. Infection with HIV interferes directly with the function of CD4(+) T cells and manipulates the host immune response to the virus. Recent studies indicate that the viral protein Nef, a central player in HIV pathogenesis, impairs the ability of infected lymphocytes to form immunological synapses with antigen-presenting cells and affects T-cell-receptor-mediated stimulation. An integrative picture of the abnormal behaviour of HIV-infected lymphocytes is therefore emerging. We propose that modulating lymphocyte signalling, apoptosis and intracellular trafficking ensures efficient spread of the virus in the hostile environment of the immune system.

http://www.ncbi.nlm.nih.gov/pubmed/17380160